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  4. Recombinant Human Scrapie-responsive protein 1 (SCRG1)

Recombinant Human Scrapie-responsive protein 1 (SCRG1)

In Stock
  • 中文名称：
    人SCRG1重组蛋白
  • 货号：
    CSB-EP530448HUa0
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    SCRG1
  • Uniprot No.：
  • 别名：
    AW124307; Scrapie-responsive gene 1 protein; Scrapie-responsive protein 1; SCRG 1; ScRG-1; Scrg1; SCRG1_HUMAN; UNQ390/PRO725
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    12.9 kDa
  • 表达区域：
    21-98aa
  • 氨基酸序列
    MPANRLSCYRKILKDHNCHNLPEGVADLTQIDVNVQDHFWDGKGCEMICYCNFSELLCCPKDVFFGPKISFVIPCNNQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：

    CUSABIO used E.coli cells to express N-terminal 6xHis-SUMO-tagged human Scrapie-responsive protein 1 (Scrg1). This recombinant Scrg1 protein is full-length of mature protein containing 21-98aa of mouse Scrg1. Its purity reached up to 90% measured by SDS-PAGE. Under reducing conditions, a molecular weight band of around 14-16 kDa was visualized on the gel. Not only being an immunogen for specific antibody production, but this recombinant Scrg1 protein may also be used in the studies of Scrg1-related signal transduction.

    Scrg1 is a transcription factor that promotes chondrogenic gene expression. Human Scrg1 participates in self-renewal, migration, osteogenic differentiation, and chondrogenic differentiation of mesenchymal stem cells (MSCs) by maintaining the expression of octamer-binding transcription factor 4 (Oct-4) and CD271/low-affinity nerve growth factor receptor (LNGFR). In MSCs, Scrg1 promotes cell migration through the β1 integrin/focal adhesion kinase (FAK) -dependent PI3K/Akt pathway. Manabu Inoue etc. Scrg1 inhibits LPS-induced chemokine CCL22 expression through the activation of the ERK1/2 signaling pathway in mouse macrophage Raw264.7 cells.

  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells. PMID: 24413464
    2. Aomatsu et al. identified a novel SCRG1/BST1 (CD157) ligand-receptor combination that maintains human mesenchymal stem cells expressions of stem cell markers Oct-4 and CD271 (LNGFR), as well as self-renewal, migration, and osteogenic differentiation potentials during ex vivo expansion. PMID: 24413464
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    SCRG1 family
  • 组织特异性：
    Expressed abundantly in the central nervous system of adult, but not at all in fetal brain. High levels of SCRG1 transcripts are also observed in testis and aorta.
  • 数据库链接：

    HGNC: 17036

    OMIM: 603163

    KEGG: hsa:11341

    STRING: 9606.ENSP00000296506

    UniGene: Hs.7122