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  4. Recombinant Human SOSS complex subunit C (SSBIP1)

Recombinant Human SOSS complex subunit C (SSBIP1)

  • 中文名称：
    人INIP重组蛋白
  • 货号：
    CSB-YP885713HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人INIP重组蛋白
  • 货号：
    CSB-EP885713HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人INIP重组蛋白
  • 货号：
    CSB-EP885713HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人INIP重组蛋白
  • 货号：
    CSB-BP885713HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人INIP重组蛋白
  • 货号：
    CSB-MP885713HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    INIP
  • Uniprot No.：
  • 别名：
    Chromosome 9 open reading frame 80; hSSBIP1; MISE; RP11-276E15.2; Sensor of single-strand DNA complex subunit C; Sensor of ssDNA subunit C; Single-stranded DNA-binding protein-interacting protein 1; SOSS C; SOSS complex subunit C; SOSS-C; SOSSC; SOSSC_HUMAN; SSB-interacting protein 1; Ssbip1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-104
  • 氨基酸序列
    AANSSGQGF QNKNRVAILA ELDKEKRKLL MQNQSSTNHP GASIALSRPS LNKDFRDHAE QQHIAAQQKA ALQHAHAHSS GYFITQDSAF GNLILPVLPR LDPE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
  • 基因功能参考文献：
    1. INTS3, but not C9ORF80, affects the nucleic acid-binding ability of hNABP1 and hNABP2, indicating that INTS3 might regulate hNABP1/hNABP2 biological function, while the role of C9ORF80 remains unknown. PMID: 29150435
    2. SOSS-C is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability. PMID: 19683501
    3. hSSBIP1 forms complexes with INTS3/hSSB1 and INTS3/hSSB2 and participates in the DNA damage response PMID: 19605351
    4. MISE is part of the INTS3/MISE/hSSB1 (IMS1) complex, which controls the DNA damage response PMID: 19786574
  • 亚细胞定位：
    Nucleus. Note=Localizes to nuclear foci following DNA damage.
  • 蛋白家族：
    SOSS-C family
  • 数据库链接：

    HGNC: 24994

    OMIM: 613273

    KEGG: hsa:58493

    STRING: 9606.ENSP00000363360

    UniGene: Hs.658575