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  4. Recombinant Human SEC14 domain and spectrin repeat-containing protein 1 (SESTD1)

Recombinant Human SEC14 domain and spectrin repeat-containing protein 1 (SESTD1)

  • 中文名称：
    人SESTD1重组蛋白
  • 货号：
    CSB-YP801241HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SESTD1重组蛋白
  • 货号：
    CSB-EP801241HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SESTD1重组蛋白
  • 货号：
    CSB-EP801241HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SESTD1重组蛋白
  • 货号：
    CSB-BP801241HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SESTD1重组蛋白
  • 货号：
    CSB-MP801241HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SESTD1
  • Uniprot No.：
  • 别名：
    huntingtin interacting protein like protein; Huntingtin-interacting protein-like protein; Protein Solo; SEC14 and spectrin domains 1; SEC14 domain and spectrin repeat-containing protein 1; SESD1_HUMAN; sestd1; SOLO
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-696
  • 氨基酸序列
    MEASVILPIL KKKLAFLSGG KDRRSGLILT IPLCLEQTNM DELSVTLDYL LSIPSEKCKA RGFTVIVDGR KSQWNVVKTV VVMLQNVVPA EVSLVCVVKP DEFWDKKVTH FCFWKEKDRL GFEVILVSAN KLTRYIEPCQ LTEDFGGSLT YDHMDWLNKR LVFEKFTKES TSLLDELALI NNGSDKGNQQ EKERSVDLNF LPSVDPETVL QTGHELLSEL QQRRFNGSDG GVSWSPMDDE LLAQPQVMKL LDSLREQYTR YQEVCRQRSK RTQLEEIQQK VMQVVNWLEG PGSEQLRAQW GIGDSIRASQ ALQQKHEEIE SQHSEWFAVY VELNQQIAAL LNAGDEEDLV ELKSLQQQLS DVCYRQASQL EFRQNLLQAA LEFHGVAQDL SQQLDGLLGM LCVDVAPADG ASIQQTLKLL EEKLKSVDVG LQGLREKGQG LLDQISNQAS WAYGKDVTIE NKENVDHIQG VMEDMQLRKQ RCEDMVDVRR LKMLQMVQLF KCEEDAAQAV EWLSELLDAL LKTHIRLGDD AQETKVLLEK HRKFVDVAQS TYDYGRQLLQ ATVVLCQSLR CTSRSSGDTL PRLNRVWKQF TIASEERVHR LEMAIAFHSN AEKILQDCPE EPEAINDEEQ FDEIEAVGKS LLDRLTVPVV YPDGTEQYFG SPSDMASTAE NIRDRMKLVN LKRQQLRHPE MVTTES
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1.
  • 基因功能参考文献：
    1. Solo plays a crucial role in HD formation and acinar development in epithelial cells by regulating mechanical force-induced RhoA activation and keratin filament organization. PMID: 29672603
    2. The interplay between Solo protein and keratin 8/keratin 18 filaments plays a crucial role in tensile force-induced RhoA activation and consequent actin cytoskeletal reinforcement in endothelial cells. PMID: 26823019
    3. Upregulation of miR-532-5p and subsequent suppression of the SESTD1 and TAB3 genes represent an antiviral response aimed at limiting West Nile virus infection. PMID: 26676784
    4. SESTD1 was found to associate with TRPC4 and TRPC5 via the channel's calmodulin- and inositol 1,4,5-trisphosphate receptor-binding domain. PMID: 20164195
  • 蛋白家族：
    SOLO family
  • 组织特异性：
    Broad expression. High expression in thalamus and brain. Significantly expressed in vasculature.
  • 数据库链接：

    HGNC: 18379

    KEGG: hsa:91404

    STRING: 9606.ENSP00000415332

    UniGene: Hs.30977