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  4. Recombinant Human S-formylglutathione hydrolase (ESD)

Recombinant Human S-formylglutathione hydrolase (ESD)

  • 中文名称：
    人ESD重组蛋白
  • 货号：
    CSB-YP007823HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ESD重组蛋白
  • 货号：
    CSB-EP007823HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ESD重组蛋白
  • 货号：
    CSB-EP007823HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ESD重组蛋白
  • 货号：
    CSB-BP007823HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ESD重组蛋白
  • 货号：
    CSB-MP007823HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ESD
  • Uniprot No.：
  • 别名：
    EC 3.1.2.12 ; Es-10; Es10; ESD; ESTD_HUMAN; Esterase 10; Esterase D; Esterase D formylglutathione hydrolase; FGH; FGH, included; FLJ11763; Methylumbelliferyl acetate deacetylase; MGC139609; OTTHUMP00000018374 ; OTTHUMP00000040929 ; S formylglutathione hydrolase; S-formylglutathione hydrolase; S-formylglutathione hydrolase, included; Sid 478; sid478
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-282
  • 氨基酸序列
    MALKQISSNK CFGGLQKVFE HDSVELNCKM KFAVYLPPKA ETGKCPALYW LSGLTCTEQN FISKSGYHQS ASEHGLVVIA PDTSPRGCNI KGEDESWDFG TGAGFYVDAT EDPWKTNYRM YSYVTEELPQ LINANFPVDP QRMSIFGHSM GGHGALICAL KNPGKYKSVS AFAPICNPVL CPWGKKAFSG YLGTDQSKWK AYDATHLVKS YPGSQLDILI DQGKDDQFLL DGQLLPDNFI AACTEKKIPV VFRLQEGYDH SYYFIATFIT DHIRHHAKYL NA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Serine hydrolase involved in the detoxification of formaldehyde.
  • 基因功能参考文献：
    1. rs7996797 located on chr13q14.1-q14.2 near the ESD gene was the most significantly associated with hallux valgus in females in genome-wide association meta-analyses. PMID: 26337638
    2. Abhydrolase domain-containing protein 11 and Esterase D predict the development of distant metastases and the presence of aggressive lung adenocarcinomas. PMID: 21596165
    3. The analysis involved the data on nine polymorphic codominant loci: HP, GC, TF, PI, PGM1, GLO1, C3, ACP1, and ESD. The loci were selected by significance of differences in genotype frequencies between tuberculosis patients and healthy controls PMID: 12942785
    4. Autoantibodies to EsteD and BB-CK produced in experimental autoimmune uveoretinitis -induced mice were also detected in some endogenous uveitis patients, suggesting that these proteins might be autoantigens. PMID: 18552983
    5. catalytic triad residues--Ser-153, His264, and Asp230--involved in catalysis. Mutagenesis of any of the catalytic triad residues to alanine abolished the enzyme activity. Backbone amides of Leu54 & Met150 are involved in the formation of the oxyanion hole PMID: 19126594

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  • 亚细胞定位：
    Cytoplasm. Cytoplasmic vesicle.
  • 蛋白家族：
    Esterase D family
  • 数据库链接：

    HGNC: 3465

    OMIM: 133280

    KEGG: hsa:2098

    STRING: 9606.ENSP00000367992

    UniGene: Hs.432491