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  4. Recombinant Human Ribonuclease 4 (RNASE4)

Recombinant Human Ribonuclease 4 (RNASE4)

In Stock
  • 中文名称：
    人RNASE4重组蛋白
  • 货号：
    CSB-BP019796HU
  • 规格：
    ￥3168
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    RNASE4
  • Uniprot No.：
  • 别名：
    RAB1; Ribonuclease 4; Ribonuclease A B1; ribonuclease A family member 4; Ribonuclease; RNase A family; 4; RNAS4_HUMAN; RNase 4; RNASE4; RNS4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    Baculovirus
  • 分子量：
    57.8 kDa
  • 表达区域：
    29-147aa
  • 氨基酸序列
    QDGMYQRFLRQHVHPEETGGSDRYCNLMMQRRKMTLYHCKRFNTFIHEDIWNIRSICSTTNIQCKNGKMNCHEGVVKVTDCRDTGSSRAPNCRYRAIASTRRVVIACEGNPQVPVHFDG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal MBP-tagged and C-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This RNase has marked specificity towards the 3' side of uridine nucleotides.
  • 基因功能参考文献：
    1. RNASE4, STAT3, and miRNA-124 may have a regulatory association with the pathological mechanisms in Huntington's disease. PMID: 29328442
    2. Data show that the transcription of angiogenin (ANG) and ribonuclease 4 (RNASE4) promoter is influenced by RNA polymerase III (Pol III) elements and could be differentially regulated by an intragenic CCCTC binding factor (CTCF)-dependent chromatin loop. PMID: 24659782
    3. RNASE4 not only stimulates the formation of neurofilaments from mouse embryonic cortical neurons, but also protects hypothermia-induced degeneration PMID: 23143660
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Pancreatic ribonuclease family
  • 数据库链接：

    HGNC: 10047

    OMIM: 601030

    KEGG: hsa:6038

    STRING: 9606.ENSP00000381081

    UniGene: Hs.283749