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  4. Recombinant Human Rhombotin-2 (LMO2)

Recombinant Human Rhombotin-2 (LMO2)

  • 中文名称：
    人LMO2重组蛋白
  • 货号：
    CSB-YP013009HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LMO2重组蛋白
  • 货号：
    CSB-EP013009HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LMO2重组蛋白
  • 货号：
    CSB-EP013009HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LMO2重组蛋白
  • 货号：
    CSB-BP013009HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LMO2重组蛋白
  • 货号：
    CSB-MP013009HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LMO2
  • Uniprot No.：
  • 别名：
    Cysteine rich protein TTG 2; Cysteine rich protein TTG2; Cysteine-rich protein TTG-2; LIM domain only 2 (rhombotin like 1); LIM domain only 2; LIM domain only protein 2; LMO 2; LMO-2; lmo2; RBTN 2; RBTN L1; RBTN2; RBTN2_HUMAN; RBTNL 1; RBTNL1; RHOM 2; RHOM2; Rhombotin 2; Rhombotin like 1; Rhombotin-2; Rhombotin2; T cell translocation gene 2; T cell translocation protein 2; T-cell translocation protein 2; TTG 2; TTG2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-158
  • 氨基酸序列
    MSSAIERKSL DPSEEPVDEV LQIPPSLLTC GGCQQNIGDR YFLKAIDQYW HEDCLSCDLC GCRLGEVGRR LYYKLGRKLC RRDYLRLFGQ DGLCASCDKR IRAYEMTMRV KDKVYHLECF KCAACQKHFC VGDRYLLINS DIVCEQDIYE WTKINGMI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
  • 基因功能参考文献：
    1. the data in this study revealed a novel crosstalk between LMO2 and the Wnt signaling pathway during tumorigenesis and suggested that LMO2 might be a tumor suppressor in certain solid tumors. PMID: 27779255
    2. LMO2 has a predominantly cytoplasmic location in breast cancer cells. LMO2 interaction with cofilin1 regulates actin cytoskeleton dynamics, promoting tumor cell invasion and metastasis. PMID: 27880729
    3. These data indicate that Lhx2 is capable of blocking proliferation of T-ALL-derived cells by both LMO2-dependent and -independent means. We propose Lhx2 as a new molecular tool for anti-T-ALL drug development. PMID: 29278703
    4. stromal LMO2 may be responsible for zonal characteristic of Prostate cancer PMID: 27028859
    5. The transcriptional factor LMO2 regulates endothelial proliferation and angiogenesis in vitro. PMID: 27792641
    6. This article demonstrates a novel and unexpected function of the LMO2 oncogenic transcription factor in controlling DNA replication that we unravelled via an unbiased proteome-wide screen for LMO2-interacting partners. PMID: 26764384
    7. Findings suggest that LMO2 loss may be a good predictor for the presence of MYC translocation in large B-cell lymphoma. PMID: 28288039
    8. FOXP3 binds LMO2 in vitro, resulting in decreased interaction between LMO2 and TAL1, providing a molecular mechanism for FOXP3-mediated transcriptional modulation in T-ALL. PMID: 26686090
    9. recurrent activating intronic mutations of LMO2, a prominent oncogene in T-cell acute lymphoblastic leukemia (T-ALL). Heterozygous mutations were identified in PF-382 and DU.528 T-ALL cell lines in addition to 3.7% of pediatric (6 of 160) and 5.5% of adult (9 of 163) T-ALL patient samples. PMID: 28270453
    10. Data indicate a novel functional mechanism of LMO2 in facilitating the delivery of actin monomers to the branched microfilament and increasing lamellipodia/filopodia formation in basal-type breast cancer cells. PMID: 28170369
    11. we demonstrate previously unrecognized mechanisms by which LMO2 alters human T-cell development in vivo; these mechanisms correlate with human T-ALL leukemogenesis. PMID: 27302866
    12. this study revealed a novel function of LMO2 involving in the regulatory hierarchy of UBA6-USE1-FAT10ylation pathway by targeting the E1 enzyme UBA6. PMID: 27569286
    13. LMO2 is a useful marker for immunophenotypic assessment of thymic neoplasms. PMID: 26796495
    14. LMO2 was associated with increased levels of cytosolic p27(Kip1) protein. PMID: 26383528
    15. that suppression of MIR223 expression, as compared with controls, is associated with lack of differentiation and adverse cytogenetic profile, but unrelated with LMO2 protein expression or overall survival. PMID: 25710580
    16. Alanine scanning mutagenesis of the LIM interaction domain of LDB1 revealed a discrete motif, R(320)LITR, required for LMO2 binding. PMID: 26598604
    17. LMO2 expression was elevated in GBM tissues and inversely correlated with prognosis of GBM patients. Taken together, our findings describe novel dual roles of LMO2 to induce tumorigenesis and angiogenesis. PMID: 25721045
    18. Diagnostic Utility of the Germinal Center-associated Markers GCET1, HGAL, and LMO2 in Hematolymphoid Neoplasms. PMID: 25203428
    19. Data show that the Lim domain only 2 (LMO2) regulatory element (element-25) region consists of transcription factor GATA2-binding myeloid ennhancer and RUNX protein-binding T-cell repressor. PMID: 26161748
    20. Cryptic chromosomal rearrangements in the LMO2 gene were associated with T-cell acute lymphoblastic leukemia. PMID: 25682596
    21. results suggest that E47 has diverse effects in T-ALL but that functional deficiency of E47 is not a universal feature of Lmo2-induced T-ALL. PMID: 25499232
    22. HHEX is a direct transcriptional target of LMO2 consistent with its concordant gene expression. PMID: 24465765
    23. LMO2 is expressed in a subset of acute myeloid leukaemia patients and is associated with normal karyotype, which is different from T lymphoblastic lymphoma/leukaemia, where specific translocation (11p13) mediates protein expression. PMID: 24330148
    24. GATA2 and Lmo2 cooperatively regulate VEGF-induced angiogenesis and lymphangiogenesis via NRP2. PMID: 23892628
    25. In t(8;21) leukemia cells, LMO2 functions as a component of the stable AML1-ETO-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis. PMID: 23812588
    26. a regulatory hierarchy of HOX control of LMO2 in normal development PMID: 23708655
    27. Staining for LMO2 in addition to CD10 and BCL6 facilitates the detection of a germinal center phenotype in follicular lymphoma PMID: 23897248
    28. HGAL and LMO2 may be useful adjuncts in the identification of follicular lymphoma of the nongastric gastrointestinal tract. PMID: 22914613
    29. LMO2 expression is a special feature of germinal center diffuse large B cell lymphomas. PMID: 22776842
    30. Transcriptional regulators cooperate to establish or maintain primitive stem cell-like signatures in leukemic cells. PMID: 23327922
    31. The new anti-LMO2 antibody can be applied confidently to routine sections, contributing to the differential diagnosis of several lymphoma subtypes, subtyping of DLBCLs and potential development of innovative therapies. PMID: 22394247
    32. Germline genetic variation in LMO2 was associated with diffuse large B-cell lymphoma prognosis and provided slightly stronger predictive ability relative to LMO2 immunohistochemistry status. PMID: 22066713
    33. evidence that the H3K9-me1/2 demethylase KDM3B might play a role in leukemogenesis via activation of lmo2 through interdependent actions with the histone acetyltransferase complex containing CBP PMID: 22615488
    34. Overexpression of LMO2 in diffuse large B-cell (DLBCL) cell lines results in centrosome amplification. PMID: 22517897
    35. B-cell acute lymphoblastic leukemia cases expressed variable levels of LMO2 depending on immunophenotypical and cytogenetic features PMID: 21459790
    36. SStudies suggest that the expression of LMO2 protein in lymphoma tissue biopsies predicts survival in patients with RA who have developed DLBCL PMID: 21375434
    37. Data suggest that both HGAL and LMO2 are directly regulated by the transcription repressor PRDM1--overexpression of PRDM1 down-regulates HGAL and LMO2; PRDM1 directly binds to promoters of both HGAL and LMO2 and represses genetic transcription. PMID: 21722313
    38. The measurement of a single gene expressed by tumor cells (LMO2) and a single gene expressed by the immune microenvironment (TNFRSF9) powerfully predicts overall survival in patients with diffuse large B-cell lymphoma. PMID: 21670469
    39. LMO2 is sensitive and specific marker for detecting follicular lymphoma in nodal and extranodal sites PMID: 21502424
    40. both Lmo2 and Bcl-2 are required for the action of E2A-HLF in leukemogenesis PMID: 21072044
    41. first structural model of the DNA-binding complex containing LMO2, LDB1, SCL/TAL1, and GATA-1 PMID: 21076045
    42. Multiple-wavelength anomalous dispersion (MAD) data have been collected at the zinc X-ray absorption edge to a resolution of 2.8 A and the data were used to solve the structure of the LMO2:Ldb1-LIM-interaction domain complex. PMID: 21045296
    43. LMO2 probably promotes angiogenesis by up-regulation of bFGF expression and thereby consequently influences progression of infantile haemangiomas PMID: 20955387
    44. As LMO2 controls hematopoiesis, its dysregulation is leukemogenic PMID: 21059912
    45. Overexpression of either KLF1 or LMO2 partially rescued the defect in erythropoiesis caused by c-myb silencing, whereas only KLF1 was also able to repress the megakaryocyte differentiation enhanced in Myb-silenced CD34+ cells. PMID: 20686118
    46. ectopically expressed LMO2 impaired the function of DeltaEF1 in both transcriptional and protein levels and identified DeltaEF1 as a novel pathogenic target of LMO2 in T-cell leukemia. PMID: 20731704
    47. a self-sustaining triad of LMO2/ERG/FLI1 stabilizes the expression of important mediators of the leukaemic phenotype such as HHEX/PRH. PMID: 20676125
    48. We report that LMO2 protein is expressed in a significant proportion of B-ALL and AML and the staining of LMO2 protein does not predict survival in acute leukemia. PMID: 20557670
    49. E2A-HLF promotes cell survival of t(17;19)- acute lymphoblastic leukemia cells by aberrantly up-regulating LMO2 expression PMID: 20519628
    50. Our results show that HGAL and LMO2 are sensitive markers for follicular lymphoma diagnosis. PMID: 20697248

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  • 相关疾病：
    A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 6642

    OMIM: 180385

    KEGG: hsa:4005

    STRING: 9606.ENSP00000257818

    UniGene: Hs.34560