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  4. Recombinant Human Rho-related GTP-binding protein Rho6 (RND1)

Recombinant Human Rho-related GTP-binding protein Rho6 (RND1)

  • 中文名称：
    人RND1重组蛋白
  • 货号：
    CSB-YP835694HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RND1重组蛋白
  • 货号：
    CSB-EP835694HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RND1重组蛋白
  • 货号：
    CSB-EP835694HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RND1重组蛋白
  • 货号：
    CSB-BP835694HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RND1重组蛋白
  • 货号：
    CSB-MP835694HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RND1
  • Uniprot No.：
  • 别名：
    ARHS; FLJ42294; GTP binding protein RHO6; Ras homolog gene family member S; RHO 6; Rho family GTPase 1; Rho related GTP binding protein Rho6; RHO S; Rho-related GTP-binding protein Rho6; RHO6; RHOS; RND 1; Rnd1; RND1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-229
  • 氨基酸序列
    MKERRAPQPV VARCKLVLVG DVQCGKTAML QVLAKDCYPE TYVPTVFENY TACLETEEQR VELSLWDTSG SPYYDNVRPL CYSDSDAVLL CFDISRPETV DSALKKWRTE ILDYCPSTRV LLIGCKTDLR TDLSTLMELS HQKQAPISYE QGCAIAKQLG AEIYLEGSAF TSEKSIHSIF RTASMLCLNK PSPLPQKSPV RSLSKRLLHL PSRSELISST FKKEKAKSC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.
  • 基因功能参考文献：
    1. Reduced RND1 expression in HCC was associated with cancer progression, likely through regulation of the Ras signaling pathway. PMID: 27770342
    2. Studies suggest that Rho GTPase signalling is a complicated mechanism in RhoA-driven cancer cell invasive migration. PMID: 27913679
    3. RND1 plays an important role in the progression of esophageal squamous cell carcinoma PMID: 26250459
    4. These results reveal a previously unappreciated mechanism through which Rnd1 restrains activation of Ras-MAPK signalling and breast tumour initiation and progression PMID: 25531777
    5. Data indicate that Rnd1 efficiently displaces Rac1 from its complex with Plexin-B1 but not vice versa. PMID: 23603360
    6. role of the N-terminal region in signaling; Rnd1 and Rnd3 have a KERRA (Lys-Glu-Arg-Arg-Ala) sequence of amino acids in their N-terminus, which functions as the lipid raft-targeting determinant; the sequence mediates lipid raft targeting of p190 RhoGAP correlated with its activation PMID: 22357615
    7. Rnd1 does not play a role in the activation of plexin-C1 and -D1 PMID: 21610070
    8. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers PMID: 11940653
    9. The RND1 mRNA expression levels increased significantly after gestation in myometria. PMID: 16311049
    10. Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain PMID: 17916560

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Small GTPase superfamily, Rho family
  • 组织特异性：
    Mostly expressed in brain and liver.
  • 数据库链接：

    HGNC: 18314

    OMIM: 609038

    KEGG: hsa:27289

    STRING: 9606.ENSP00000308461

    UniGene: Hs.124940