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  4. Recombinant Human Replication factor C subunit 3 (RFC3)

Recombinant Human Replication factor C subunit 3 (RFC3)

  • 中文名称：
    人RFC3重组蛋白
  • 货号：
    CSB-YP019590HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RFC3重组蛋白
  • 货号：
    CSB-EP019590HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RFC3重组蛋白
  • 货号：
    CSB-EP019590HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RFC3重组蛋白
  • 货号：
    CSB-BP019590HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RFC3重组蛋白
  • 货号：
    CSB-MP019590HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    A1 38 kDa subunit; Activator 1 38 kDa subunit; Activator 1 subunit 3; HGNC:9971; MGC5276; Replication factor C (activator 1) 3; Replication factor C (activator 1) 3, 38kDa; Replication factor C 3; Replication factor C 38 kDa subunit; Replication factor C subunit 3; RF-C 38 kDa subunit; RFC 38 kD subunit; RFC 38 kDa subunit; RFC3; RFC3_HUMAN; RFC38
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-356
  • 氨基酸序列
    MSLWVDKYRP CSLGRLDYHK EQAAQLRNLV QCGDFPHLLV YGPSGAGKKT RIMCILRELY GVGVEKLRIE HQTITTPSKK KIEISTIASN YHLEVNPSDA GNSDRVVIQE MLKTVAQSQQ LETNSQRDFK VVLLTEVDKL TKDAQHALRR TMEKYMSTCR LILCCNSTSK VIPPIRSRCL AVRVPAPSIE DICHVLSTVC KKEGLNLPSQ LAHRLAEKSC RNLRKALLMC EACRVQQYPF TADQEIPETD WEVYLRETAN AIVSQQTPQR LLEVRGRLYE LLTHCIPPEI IMKGLLSELL HNCDGQLKGE VAQMAAYYEH RLQLGSKAIY HLEAFVAKFM ALYKKFMEDG LEGMMF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.
  • 基因功能参考文献：
    1. The expression level of RFC3 was markedly upregulated in the HCC tissues and cells. PMID: 26397132
    2. The expression level of RFC3 was remarkably up-regulated in ovarian cancer OVCAR-3 cells. Down-regulation of RFC3 expression arrested the cell cycle of OVCAR-3 cell in the S-phase and induced apoptosis. PMID: 26464638
    3. High RFC3 expression is associated with neoplastic myelopoiesis. PMID: 25541153
    4. our findings suggest that RFC3 protein is an important and independent biomarker with prognostic implications for patients with ovarian carcinoma. PMID: 25030735
    5. 9-cis-RA-activated RXRalpha suppresses the growth of retinoid-sensitive breast cancer and embryonic cells through RFC3. PMID: 22949521
    6. Data identified RFC3 as a candidate oncogene amplified in esophageal adenocarcinoma (EAC). PMID: 22328562
    7. RFC3 mutation and loss of RFC3 expression occur in large fractions of gastric and colorectal cancers and suggest that these alterations may contribute to the cancer pathogenesis by deregulating DNA repair and replication. PMID: 20573375

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Activator 1 small subunits family
  • 数据库链接：

    HGNC: 9971

    OMIM: 600405

    KEGG: hsa:5983

    STRING: 9606.ENSP00000369411

    UniGene: Hs.115474