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  4. Recombinant Human Regulatory solute carrier protein family 1 member 1 (RSC1A1)

Recombinant Human Regulatory solute carrier protein family 1 member 1 (RSC1A1)

  • 中文名称：
    人RSC1A1重组蛋白
  • 货号：
    CSB-YP838797HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RSC1A1重组蛋白
  • 货号：
    CSB-EP838797HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RSC1A1重组蛋白
  • 货号：
    CSB-EP838797HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RSC1A1重组蛋白
  • 货号：
    CSB-BP838797HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RSC1A1重组蛋白
  • 货号：
    CSB-MP838797HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RSC1A1
  • Uniprot No.：
  • 别名：
    RSC1A1; Regulatory solute carrier protein family 1 member 1; Transporter regulator RS1; hRS1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-617
  • 氨基酸序列
    MSSLPTSDGF NHPARSSGQS PDVGNPMSLA RSVSASVCPI KPSDSDRIEP KAVKALKASA EFQLNSEKKE HLSLQDLSDH ASSADHAPTD QSPAMPMQNS SEEITVAGNL EKSAERSTQG LKFHLHTRQE ASLSVTSTRM HEPQMFLGEK DWHPENQNLS QVSDPQQHEE PGNEQYEVAQ QKASHDQEYL CNIGDLELPE ERQQNQHKIV DLEATMKGNG LPQNVDPPSA KKSIPSSECS GCSNSETFME IDTAQQSLVT LLNSTGRQNA NVKNIGALDL TLDNPLMEVE TSKCNPSSEI LNDSISTQDL QPPETNVEIP GTNKEYGHYS SPSLCGSCQP SVESAEESCP SITAALKELH ELLVVSSKPA SENTSEEVIC QSETIAEGQT SIKDLSERWT QNEHLTQNEQ CPQVSFHQAI SVSVETEKLT GTSSDTGREA VENVNFRSLG DGLSTDKEGV PKSRESINKN RSVTVTSAKT SNQLHCTLGV EISPKLLAGE EDALNQTSEQ TKSLSSNFIL VKDLGQGIQN SVTDRPETRE NVCPDASRPL LEYEPPTSHP SSSPAILPPL IFPATDIDRI LRAGFTLQEA LGALHRVGGN ADLALLVLLA KNIVVPT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network.
  • 基因功能参考文献：
    1. Binding of RS1-Reg to ODC1 inhibits the enzymatic activity at low intracellular glucose, which is blunted at high intracellular glucose. PMID: 27555600
    2. Taken together, these data indicate that RSC1A1 modulates dynamin-dependent trafficking of intracellular vesicles containing hSGLT1 in Xenopus oocytes, and modulates PKC-dependent short-term regulation of this transporter. PMID: 14724758
    3. hRS1 protein exhibits glucose-dependent, short-term inhibition of hSGLT1 and hOCT2 by inhibiting the release of vesicles from the trans-Golgi network PMID: 16788146
    4. RS1 inhibits the dynamin-dependent release of SGLT1-containing vesicles from the trans-golgi network PMID: 16788147
    5. RSC1A1 codes for a 67-kDa protein named RS1 that mediates transcriptional and post-transcriptional regulation of Na(+)-D-glucose cotransporter SGLT1. PMID: 17686765

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  • 亚细胞定位：
    Cell membrane. Nucleus. Golgi apparatus, trans-Golgi network. Note=Localizes at the inner side of the plasma membrane.
  • 组织特异性：
    Expressed in small intestine, kidney and brain.
  • 数据库链接：

    HGNC: 10458

    OMIM: 601966

    KEGG: hsa:6248

    STRING: 9606.ENSP00000341963

    UniGene: Hs.239459