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  4. Recombinant Human Regulation of nuclear pre-mRNA domain-containing protein 1A (RPRD1A)

Recombinant Human Regulation of nuclear pre-mRNA domain-containing protein 1A (RPRD1A)

  • 中文名称：
    人RPRD1A重组蛋白
  • 货号：
    CSB-YP850404HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RPRD1A重组蛋白
  • 货号：
    CSB-EP850404HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RPRD1A重组蛋白
  • 货号：
    CSB-EP850404HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RPRD1A重组蛋白
  • 货号：
    CSB-BP850404HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RPRD1A重组蛋白
  • 货号：
    CSB-MP850404HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RPRD1A
  • Uniprot No.：
  • 别名：
    C77387; CDKN2B-related protein; Cyclin dependent kinase 2B inhibitor related protein; Cyclin dependent kinase inhibitor 2B related protein (p15INK4B related protein) ; Cyclin dependent kinase inhibitor 2B related protein; Cyclin dependent kinase inhibitor related protein; Cyclin-dependent kinase inhibitor 2B-related protein; FLJ10656; HsT3101; Hypothetical protein FLJ10656; KIAA4077; MGC19513; MGC29396; MGC36325; mKIAA4077; p15INK4B related protein; p15INK4B-related protein; Putative uncharacterized protein P15RS; Regulation of nuclear pre mRNA domain containing 1A; Regulation of nuclear pre-mRNA domain-containing protein 1A; RGD1307374; RPR1A_HUMAN; RPRD1A
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-312
  • 氨基酸序列
    SAFSEAALE KKLSELSNSQ QSVQTLSLWL IHHRKHSRPI VTVWERELRK AKPNRKLTFL YLANDVIQNS KRKGPEFTKD FAPVIVEAFK HVSSETDESC KKHLGRVLSI WEERSVYEND VLEQLKQALY GDKKPRKRTY EQIKVDENEN CSSLGSPSEP PQTLDLVRAL QDLENAASGD AAVHQRIASL PVEVQEVSLL DKITDKESGE RLSKMVEDAC MLLADYNGRL AAEIDDRKQL TRMLADFLRC QKEALAEKEH KLEEYKRKLA RVSLVRKELR SRIQSLPDLS RLPNVTGSHM HLPFAGDIYS ED
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
  • 基因功能参考文献：
    1. Data suggest that p15RS (p15INK4b-related sequence) acts as an intrinsic transcriptional repressor for Wnt/beta-catenin-mediated gene transcription through recruiting HDAC2 histone deacetylase. PMID: 25697359
    2. RPRD1A and RPRD1B associate directly with RPAP2 phosphatase and coordinate the dephosphorylation of RNAPII phospho-S5 by RPAP2. PMID: 24997600
    3. The p15RS expression specifically downregulates the expression of cathepsin B and MMP-9 at RNA levels, which are known to promote cell invasion through degrading extracellular matrix proteins. PMID: 22580456
    4. p15RS inhibits Wnt signaling by interrupting beta-catenin.TCF4 complex formation and that Wnt signaling initiates downstream gene expression by removing p15RS from promoters. PMID: 20739273
    5. molecular cloning and characterization of P15RS, a novel P15(INK4b) related gene involved in G1/S progression PMID: 12470661

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  • 蛋白家族：
    UPF0400 (RTT103) family
  • 数据库链接：

    HGNC: 25560

    OMIM: 610347

    KEGG: hsa:55197

    STRING: 9606.ENSP00000349955

    UniGene: Hs.464912