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  4. Recombinant Human Ras-related protein Rab-9A (RAB9A)

Recombinant Human Ras-related protein Rab-9A (RAB9A)

  • 中文名称：
    人RAB9A重组蛋白
  • 货号：
    CSB-YP019224HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RAB9A重组蛋白
  • 货号：
    CSB-EP019224HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RAB9A重组蛋白
  • 货号：
    CSB-EP019224HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RAB9A重组蛋白
  • 货号：
    CSB-BP019224HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RAB9A重组蛋白
  • 货号：
    CSB-MP019224HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RAB9A
  • Uniprot No.：
  • 别名：
    2410064E05Rik; AI195561; DmRab9; Rab 9; RAB 9A; RAB9 member RAS oncogene family; RAB9A; RAB9A member RAS oncogene family; RAB9A_HUMAN; RAS ASSOCIATED PROTEIN RAB9; Ras related protein Rab 9A; Ras-related protein Rab-9A; Sid6061p; Sid99
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-201
  • 氨基酸序列
    AGKSSLFKV ILLGDGGVGK SSLMNRYVTN KFDTQLFHTI GVEFLNKDLE VDGHFVTMQI WDTAGQERFR SLRTPFYRGS DCCLLTFSVD DSQSFQNLSN WKKEFIYYAD VKEPESFPFV ILGNKIDISE RQVSTEEAQA WCRDNGDYPY FETSAKDATN VAAAFEEAVR RVLATEDRSD HLIQTDTVNL HRKPKPSSSC C
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the transport of proteins between the endosomes and the trans Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.
  • 基因功能参考文献：
    1. RAB9 competes with the catalytic subunit PPP2CA in binding to PPP2R1A. This competitive association has an important role in controlling the PP2A catalytic activity. PMID: 27611305
    2. protein kinase C modulates alpha1B-adrenergic receptor transfer to late endosomes and that Rab9 regulates this process and participates in G protein-mediated signaling turn-off. PMID: 28082304
    3. Rab9A and its co-regulatory GTPases control STX13-mediated cargo delivery to maturing melanosomes. PMID: 26527546
    4. Rab9-complexed TIP47 plays an essential role for the proper release of hepatitis C viral particles. PMID: 24480419
    5. Rab9a and Rab7b are mediators of the transit of the L2 capsid protien and the pseudogenome of human papillomavirus 16 from the late endosome to the golgi complex. PMID: 23345514
    6. Rab9A and Rab23 GTPases play crucial roles in autophagy of Group A Streptococcus. PMID: 22452336
    7. These data show that RUTBC2 can act as a Rab36 GAP in cells and suggest that RUTBC2 links Rab9A function to Rab36 function in the endosomal system. PMID: 22637480
    8. RUTBC1 is a Tre2/Bub2/Cdc16 domain-containing protein that binds to Rab9A-GTP both in vitro and in cultured cells, but is not a GTPase-activating protein for Rab9A. PMID: 21808068
    9. Data show that recombinant HPS1-HPS4 produced in insect cells can be efficiently isolated as a 1:1 heterodimer, and might function as a Rab9 effector in the biogenesis of lysosome-related organelles. PMID: 20048159
    10. Data show that ectopic expression of human telomerase reverse transcriptase (hTeRT) in human cells leads to an upregulation of the small GTPase Rab9 and its effector p40. PMID: 12576506
    11. The overall structure shows a characteristic nucleotide binding fold consisting of a six-stranded beta-sheet surrounded by five alpha-helices with a tightly bound GDP molecule in the active site. PMID: 15263003
    12. cholesterol contributes directly to the sequestration of Rab9 on Niemann-Pick type C cell membranes, which in turn, disrupts mannose 6-phosphate receptor trafficking PMID: 16644737
    13. Binding of the effector protein TIP47 is important for Rab9 localization. PMID: 16769818
    14. Rab9 interacts with the intermediate filament vimentin. This interaction is altered by lipid accumulation in late endosomes, which results in inhibition of protein kinase C and hypophosphorylation of vimentin, leading to late endosome dysfunction. PMID: 18681838
    15. VV p37 protein associates with host TIP47, Rab9 and CI-MPR. PMID: 19400954
    16. Data indicate that human copper transporter 1 cleavage occurs in a late endosomal, Rab9-positive compartment prior to delivery of the transporter to the plasma membrane. PMID: 19684018

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Endoplasmic reticulum membrane. Golgi apparatus membrane. Late endosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle membrane. Melanosome.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 数据库链接：

    HGNC: 9792

    OMIM: 300284

    KEGG: hsa:9367

    STRING: 9606.ENSP00000420127

    UniGene: Hs.495704