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  4. Recombinant Human Ras-related protein Rab-2A (RAB2A)

Recombinant Human Ras-related protein Rab-2A (RAB2A)

  • 中文名称：
    人RAB2A重组蛋白
  • 货号：
    CSB-EP019180HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    9330148M11Rik; C80220; GTP binding protein; LHX; OTTMUSP00000004796; RAB2; RAB2 member RAS oncogene family; RAB2A; RAB2A; member RAS oncogene family; RAB2A_HUMAN; Ras related protein Rab 2A; RAS-associated protein RAB2; Ras-related protein Rab-2A; RP23-183L6.1; Small GTP binding protein RAB2A
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    39.4kDa
  • 表达区域：
    2-212aa
  • 氨基酸序列
    AYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHAATNATHAGNQGGQQAGGGCC
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for protein transport from the endoplasmic reticulum to the Golgi complex.
  • 基因功能参考文献：
    1. S100A7 affects cell motility and invasion by regulating the RAB2A-associated MAPK signaling cascades. PMID: 27767088
    2. Identify Rab2 as a key factor for autophagic and endocytic cargo delivery to and degradation in lysosomes. PMID: 28483915
    3. our data reveal that RAB2A is new critical membrane trafficking players in the regulation of mesenchymal properties of normal and tumorigenic cells and a critical determinant of an invasive, proteolytic mode of BC progression. PMID: 27255086
    4. RAB2A variance has effect on the structure and function of the PFC and related cognitive functions. PMID: 26249043
    5. This study demonstrated that RAB2A mutation showing the highest statistical significance in Autism and Schizophrenia. PMID: 26938441
    6. The immunohistochemistry-based validation using tissue microarray slides in oral squamous cell carcinoma revealed overexpression of the RAB2A and PRDX1 gene in 80 and 68 % of the tested clinical cases, respectively. PMID: 26159854
    7. Pin1/Rab2A/Erk drives BCSC expansion and tumorigenicity, suggesting potential drug targets. PMID: 25818297
    8. As a result of the translocations, RAB2A-PLAG1, the constitutively active promoter of the partner gene drives the ectopic expression of PLAG1. PMID: 24700772
    9. first X-ray crystal structure of RicA to 2.7 A resolution and have quantified the affinity of RicA binding to human Rab2 in its GDP-bound and nucleotide-free forms PMID: 24251537
    10. The s identified a specific interaction between the human small GTPase Rab2 and a Brucella spp. protein named RicA. PMID: 21501366
    11. The results of this study provided that RAB2A and SLC38A1, were associated with the density of calbindin-positive neurons and the number of perineuronal oligodendrocytes in psychiatric disorders. PMID: 20308991
    12. Rab2 interacts directly with atypical protein kinase C iota/lambda and inhibits aPKCiota/lambda-dependent GADPH phosphorylation PMID: 14570876
    13. These data demonstrate that Rab2 and Rab6 differentially influence anterograde transport and signaling of GPCRs. PMID: 17716866
    14. ICA69 as a novel Rab2 effector and its role in regulating the early transport of insulin secretory granule proteins PMID: 18187231

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  • 亚细胞定位：
    Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor. Melanosome. Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus membrane; Lipid-anchor. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 数据库链接：

    HGNC: 9763

    OMIM: 179509

    KEGG: hsa:5862

    STRING: 9606.ENSP00000262646

    UniGene: Hs.369017