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  4. Recombinant Human Ras association domain-containing protein 4 (RASSF4)

Recombinant Human Ras association domain-containing protein 4 (RASSF4)

  • 中文名称：
    人RASSF4重组蛋白
  • 货号：
    CSB-YP880956HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RASSF4重组蛋白
  • 货号：
    CSB-EP880956HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RASSF4重组蛋白
  • 货号：
    CSB-EP880956HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RASSF4重组蛋白
  • 货号：
    CSB-BP880956HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RASSF4重组蛋白
  • 货号：
    CSB-MP880956HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RASSF4
  • Uniprot No.：
  • 别名：
    3830411C14Rik; AD037; AI586137; MGC105606; MGC44914; OTTHUMP00000019493; Ras association (RalGDS/AF 6) domain family 4; Ras association (RalGDS/AF 6) domain family member 4; Ras association domain containing protein 4; Ras association domain family 4; Ras association domain-containing protein 4; RASF4_HUMAN; RASSF 4; Rassf4; RP11-285G1.4; Tumor suppressor RASSF4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-321
  • 氨基酸序列
    MKEDCLPSSH VPISDSKSIQ KSELLGLLKT YNCYHEGKSF QLRHREEEGT LIIEGLLNIA WGLRRPIRLQ MQDDREQVHL PSTSWMPRRP SCPLKEPSPQ NGNITAQGPS IQPVHKAESS TDSSGPLEEA EEAPQLMRTK SDASCMSQRR PKCRAPGEAQ RIRRHRFSIN GHFYNHKTSV FTPAYGSVTN VRVNSTMTTL QVLTLLLNKF RVEDGPSEFA LYIVHESGER TKLKDCEYPL ISRILHGPCE KIARIFLMEA DLGVEVPHEV AQYIKFEMPV LDSFVEKLKE EEEREIIKLT MKFQALRLTM LQRLEQLVEA K
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.
  • 基因功能参考文献：
    1. RASSF4 controls store operated calcium entry and endoplasmic reticulum-plasma membrane junctions through ARF6-dependent regulation of PM PI(4,5)P2 levels, pivotal for a variety of physiological processes. PMID: 28600435
    2. RASSF4 overexpression inhibits proliferation, invasion, EMT, and Wnt signaling pathway in osteosarcoma cells. PMID: 28081736
    3. the present study suggested that RASSF4 serves as an important tumor suppressor in human nonsmall cell lung cancer . PMID: 26526576
    4. RASSF4 promotes EV71 replication and the production of viral progeny to accelerate the inhibition of the phosphorylation of AKT. PMID: 25701784
    5. expression of SPRR1B is upregulated in oral CSCs/CICs and SPRR1B has a role in cell growth by suppression of RASSF4 PMID: 23954638
    6. Single nucleotide polymorphism in RASSF4 gene is associated with acute lymphoblastic leukemia. PMID: 19066393

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  • 组织特异性：
    Widely expressed. Frequently down-regulated in tumor cell lines.
  • 数据库链接：

    HGNC: 20793

    OMIM: 610559

    KEGG: hsa:83937

    STRING: 9606.ENSP00000339692

    UniGene: Hs.522895