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  4. Recombinant Human Pygopus homolog 2 (PYGO2)

Recombinant Human Pygopus homolog 2 (PYGO2)

  • 中文名称：
    人PYGO2重组蛋白
  • 货号：
    CSB-YP883586HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PYGO2重组蛋白
  • 货号：
    CSB-EP883586HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PYGO2重组蛋白
  • 货号：
    CSB-EP883586HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PYGO2重组蛋白
  • 货号：
    CSB-BP883586HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PYGO2重组蛋白
  • 货号：
    CSB-MP883586HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PYGO2
  • Uniprot No.：
  • 别名：
    1190004M21Rik; FLJ33226; PP7910; PYGO2; Pygo2 protein; PYGO2_HUMAN; Pygopus 2; pygopus homolog 2 (Drosophila); Pygopus homolog 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-406
  • 氨基酸序列
    AASAPPPPD KLEGGGGPAP PPAPPSTGRK QGKAGLQMKS PEKKRRKSNT QGPAYSHLTE FAPPPTPMVD HLVASNPFED DFGAPKVGVA APPFLGSPVP FGGFRVQGGM AGQVPPGYST GGGGGPQPLR RQPPPFPPNP MGPAFNMPPQ GPGYPPPGNM NFPSQPFNQP LGQNFSPPSG QMMPGPVGGF GPMISPTMGQ PPRAELGPPS LSQRFAQPGA PFGPSPLQRP GQGLPSLPPN TSPFPGPDPG FPGPGGEDGG KPLNPPASTA FPQEPHSGSP AAAVNGNQPS FPPNSSGRGG GTPDANSLAP PGKAGGGSGP QPPPGLVYPC GACRSEVNDD QDAILCEASC QKWFHRECTG MTESAYGLLT TEASAVWACD LCLKTKEIQS VYIREGMGQL VAANDG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in signal transduction through the Wnt pathway.
  • 基因功能参考文献：
    1. Elevated PYGO2 expression in primary prostate adenocarcinoma is a potential risk factor for biochemical recurrence. PMID: 28924059
    2. Overexpression of Pygo2 facilitated the expression of P-glycoprotein, which acts as a drug efflux pump, by promoting the transcription of MDR1 at the MDR1 promoter loci, resulting in acceleration of the efflux of paclitaxel in human glioma cells. PMID: 28427190
    3. We also determined the effect of Pygo2 on the sensitivity of breast tumors resistant to doxorubicin in a mouse model. Finally, RNA samples from 64 paired patient tumors (before and after chemotherapy) highly and significantly overexpressed Pygo2 and/or MDR1 after treatment, thus underlining a pivotal role for the Pygo2-mediated Wnt/b-catenin pathway in the clinical chemoresistance of breast cancer. PMID: 26876203
    4. Findings are consistent with a model in which acetylation of Pygo2 by CBP/p300 family members in the active TCF/beta-catenin complex occurs coincident with histone acetylation and may be required for the recycling of Pygo2 away from the complex subsequent to target gene activation. PMID: 27647933
    5. The activation of its expression by ERalpha and/or specificity protein-1 (SP1) suggests hPYGO2 as a theranostic target for hormone therapy responsive and refractory breast cancer. PMID: 26645832
    6. Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment. PMID: 26902498
    7. this study demonstrated that SNPs in the coding region of Pygo2 might be one of the causative factors in idiopathic oligospermia and azoospermia, resulting in male infertility. PMID: 26345837
    8. Our findings suggest that Pygopus-2 may be an important predictor of poor outcome in HCC patients, and could serve as a novel biomarker for HCC. PMID: 25545771
    9. Pygopus-2 over-expression is associated with hepatic carcinoma. PMID: 25871475
    10. Pygo2 is a common node downstream of oncogenic Wnt and Akt signaling pathways. PMID: 26170450
    11. The results of the present study suggest a novel involvement of Pygo in the promotion of rRNA transcription in cancer cells PMID: 23517060
    12. We conclude that abnormal Pygo2 protein expression may be a marker for advanced non-small cell lung cancer PMID: 23865714
    13. PYGO2 is identified as a new molecular marker of invasive tumors in esophageal squamous cell carcinoma. PMID: 23456637
    14. SNPs in the coding region of Pygo2 gene may be one of the causative factors in idiopathic oligospermia and azoospermia, resulting in male infertility. PMID: 23732668
    15. Pygo2 directly occupies the promoters of multiple histone genes and enhances the acetylation of lysine 56 in histone H3. PMID: 22186018
    16. Pygo2 is highly expressed in and promotes the growth of glioma cells PMID: 20361361
    17. The study demonstrated that Pygo2 was highly expressed in glioma tissue and required for growth of glioblastoma cells. PMID: 20204459
    18. Data show that Pygo2 associates with MLL2 histone methyltransferase and STAGA histone acetyltransferase to facilitate their interaction with beta-catenin and Wnt1-induced, TCF/LEF-dependent transactivation in breast cancer cells. PMID: 20937768
    19. Pygo2 PHD is the only known PHD finger that is capable of interacting simultaneously with two functional ligands, B9L and BCL9 PMID: 20637214
    20. The Expression of pygopus 2 protein mRNA levels were significantly higher in the epithelial ovarian cancer cell lines. PMID: 16609037
    21. hPygo2 is highly expressed in, and required for the growth of breast carcinoma cells PMID: 17203217
    22. These results provide new evidence that Elf-1 is involved in transcriptional activation of hPygo2. PMID: 18314487
    23. Data support a model in which the NHD region of Pygopus is required to augment transcriptional activation by a mechanism that includes both transcriptional activation and histone acetylation resulting from the recruitment of the CBP. PMID: 19555349

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 30257

    OMIM: 606903

    KEGG: hsa:90780

    STRING: 9606.ENSP00000357442

    UniGene: Hs.533597