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  4. Recombinant Human Protein dpy-30 homolog (DPY30)

Recombinant Human Protein dpy-30 homolog (DPY30)

  • 中文名称：
    人DPY30重组蛋白
  • 货号：
    CSB-YP861193HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人DPY30重组蛋白
  • 货号：
    CSB-EP861193HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人DPY30重组蛋白
  • 货号：
    CSB-EP861193HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人DPY30重组蛋白
  • 货号：
    CSB-BP861193HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人DPY30重组蛋白
  • 货号：
    CSB-MP861193HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DPY30
  • Uniprot No.：
  • 别名：
    Dpy-30-like protein; Dpy-30L; DPY30; DPY30_HUMAN; HDPY-30; Protein dpy-30 homolog; Saf19
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-99
  • 氨基酸序列
    MEPEQMLEGQ TQVAENPHSE YGLTDNVERI VENEKINAEK SSKQKVDLQS LPTRAYLDQT VVPILLQGLA VLAKERPPNP IEFLASYLLK NKAQFEDRN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.
  • 基因功能参考文献：
    1. Dpy30 role in cellular reprogramming and its interactions with Set1 complex PMID: 26691508
    2. results indicate that DPY30 has critical roles in the proliferation, migration, and invasion of gastric cancer cells, and suggest DPY30 might be a therapeutic target in gastric cancer PMID: 26147337
    3. Based on our structural data and cross-linking results, we suggest that Dpy30 may regulate H3K4 methylation according to its copy number in COMPASS PMID: 25542209
    4. these results form the basis for understanding how WRAD(DRY-30) differentially regulates SET1 family complexes in vivo. PMID: 25561738
    5. The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells. PMID: 25139354
    6. A deletion mutation and reduced DPY30 expression in a Spastic Paraplegia type 4 Japanese family. PMID: 24690193
    7. DPY30 regulates pathways in cellular senescence through ID protein expression. PMID: 23872946
    8. determination of the minimum motif of Ash2L that is required for DPY30 interaction; a structural model for the Ash2L-DPY30 interaction PMID: 22231628
    9. First report of SPG4 associated with partial deletions of both the SPAST and DPY30 genes. The partial heterozygous deletion of DPY30 could modify the phenotypic expression of SPG4 patients with this pedigree. PMID: 20857310
    10. The DPY-30 C-terminal domain structure, harboring the conserved DPY-30 motif, is composed of two alpha-helices linked by a sharp loop and forms a typical X-type four-helix bundle required for dimer formation. PMID: 19481096
    11. hDPY-30 (dpy-30-like protein) binds ASH2L directly. The evolutionarily conserved hDPY-30, ASH2L, RBBP5 and WDR5 likely constitute a subcomplex that is shared by all human Set1-like HMT complexes. PMID: 17500065

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  • 亚细胞定位：
    Nucleus. Golgi apparatus, trans-Golgi network.
  • 蛋白家族：
    Dpy-30 family
  • 数据库链接：

    HGNC: 24590

    OMIM: 612032

    KEGG: hsa:84661

    STRING: 9606.ENSP00000295066

    UniGene: Hs.531788