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  4. Recombinant Human Protein-cysteine N-palmitoyltransferase HHAT (HHAT), partial

Recombinant Human Protein-cysteine N-palmitoyltransferase HHAT (HHAT), partial

  • 中文名称：
    人HHAT重组蛋白
  • 货号：
    CSB-YP719621HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HHAT重组蛋白
  • 货号：
    CSB-EP719621HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HHAT重组蛋白
  • 货号：
    CSB-EP719621HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HHAT重组蛋白
  • 货号：
    CSB-BP719621HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HHAT重组蛋白
  • 货号：
    CSB-MP719621HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HHAT
  • Uniprot No.：
  • 别名：
    2810432O22Rik; AC115917.1; AI462858; FLJ10724; FLJ34867; Hedgehog acyltransferase; Hhat; HHAT_HUMAN; MART 2; MART-2; MART2; Melanoma antigen recognized by T cells 2; Melanoma antigen recognized by T-cells 2; MGC11697; OTTMUSP00000033669; Protein cysteine N palmitoyltransferase HHAT; Protein-cysteine N-palmitoyltransferase HHAT; RGD1311746; SKI1; Skinny hedgehog protein 1; Skinny hedgehog protein; Skn
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling. Promotes the transfer of palmitoyl-CoA from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane, where SHH palmitoylation occurs.
  • 基因功能参考文献：
    1. Hhat plays a critical role in ER positive, HER2 amplified, and hormone resistant breast cancer proliferation. PMID: 25889650
    2. Data suggest that substrate specificity of hedgehog acyltransferase (HHAT) in palmitoylation reaction extends to oligopeptide fragments of Sonic hedgehog protein (SHH). PMID: 26334609
    3. analysis of hedgehog acyltransferase membrane topology PMID: 25488661
    4. provide the first clinical evidence of the essential role played by lipid modification of Hh proteins in human testicular organogenesis and embryonic development PMID: 24784881
    5. rs7527939 is the strongest indicator of susceptibility to schizophrenia in the Bulgarian population within the HHAT locus. PMID: 23142968
    6. SKN is necessary for the proliferation of the non-small cell lung carcinoma cells PMID: 22733134
    7. These findings define residues and regions within Shh that are necessary for its recognition as a substrate for Hhat-mediated palmitoylation. PMID: 23112049
    8. SKI-1/S1P activity is thus essential for hepatitis C virus production and its inhibition should be considered for antiviral drug development. PMID: 22626636

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Membrane-bound acyltransferase family, HHAT subfamily
  • 组织特异性：
    Ubiquitously expressed in normal tissues and cancer cell lines.
  • 数据库链接：

    HGNC: 18270

    OMIM: 605743

    KEGG: hsa:55733

    STRING: 9606.ENSP00000438468

    UniGene: Hs.58650