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  4. Recombinant Human Protein Wnt-9b (WNT9B)

Recombinant Human Protein Wnt-9b (WNT9B)

  • 中文名称：
    人WNT9B重组蛋白
  • 货号：
    CSB-YP026146HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人WNT9B重组蛋白
  • 货号：
    CSB-EP026146HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人WNT9B重组蛋白
  • 货号：
    CSB-EP026146HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人WNT9B重组蛋白
  • 货号：
    CSB-BP026146HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人WNT9B重组蛋白
  • 货号：
    CSB-MP026146HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    WNT9B; WNT14B; WNT15; UNQ6973/PRO21956; Protein Wnt-9b; Protein Wnt-14b; Protein Wnt-15
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-357
  • 氨基酸序列
    SYFGLTGR EVLTPFPGLG TAAAPAQGGA HLKQCDLLKL SRRQKQLCRR EPGLAETLRD AAHLGLLECQ FQFRHERWNC SLEGRMGLLK RGFKETAFLY AVSSAALTHT LARACSAGRM ERCTCDDSPG LESRQAWQWG VCGDNLKYST KFLSNFLGSK RGNKDLRARA DAHNTHVGIK AVKSGLRTTC KCHGVSGSCA VRTCWKQLSP FRETGQVLKL RYDSAVKVSS ATNEALGRLE LWAPARQGSL TKGLAPRSGD LVYMEDSPSF CRPSKYSPGT AGRVCSREAS CSSLCCGRGY DTQSRLVAFS CHCQVQWCCY VECQQCVQEE LVYTCKH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development.
  • 基因功能参考文献：
    1. Our study further supports the involvement of WNT9B as a cleft susceptibility gene in Brazilian families experiencing NSCL+/-P. Although additional studies are still necessary to unveil the exact mechanism by which WNT genes would contribute to NSCL+/-P, allelic polymorphisms in these genes and their interactions may partly explain the variance of individual susceptibility to NSCL+/-P. PMID: 24437584
    2. Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype PMID: 28915250
    3. This association study successfully identified two susceptibility Single Nucleotide Polymorphisms, (WNT9B and PBX1) associated with Mayer-Rokitansky-Kuster-Hauser syndrome risk, both separately and interactively. PMID: 26075712
    4. results indicate that mutations in the coding sequence of WNT9B are not responsible for Mullerian duct abnormalities in the Chinese population PMID: 24581601
    5. Two novel mutations (a missense mutation in exon 1, and one in the 3-UTR) may be pathogenic variants in Mayer-Rokitansky-Kuster-Hauser syndrome patients and warrant further functional study. PMID: 24268733
    6. The signals from the stromal fibroblasts cooperate with Wnt9b to promote differentiation of the progenitor cells. PMID: 23974041

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix. Secreted.
  • 蛋白家族：
    Wnt family
  • 组织特异性：
    Moderately expressed in fetal kidney and adult kidney. Also found in brain.
  • 数据库链接：

    HGNC: 12779

    OMIM: 602864

    KEGG: hsa:7484

    STRING: 9606.ENSP00000290015

    UniGene: Hs.326420