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  4. Recombinant Human Prorelaxin H1 (RLN1)

Recombinant Human Prorelaxin H1 (RLN1)

  • 货号：
    CSB-YP019749HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019749HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019749HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019749HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019749HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RLN1
  • Uniprot No.：
  • 别名：
    H1; H1RLX; Preprorelaxin H1; Prorelaxin; Prorelaxin H1; REL1_HUMAN; Relaxin A chain; Relaxin H1; RLN 1; Rln1; RLXH1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    23-53
  • 氨基酸序列
    VAAKWKDD VIKLCGRELV RAQIAICGMS TWS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
  • 基因功能参考文献：
    1. Results indicate that serum relaxin may be a clinically useful indicator for diagnostic and prognostic evaluation in epithelial ovarian cancer (EOC) patients. PMID: 29060928
    2. down-regulated in cord blood by prenatal smoking PMID: 28130959
    3. In a population of acute HF patients, admission relaxin serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin as a biomarker in this setting. PMID: 27488261
    4. The digestive tract has been shown to express relaxin receptors; the hormone appears to exert site-specific effects acting at the neural or at the smooth muscle level, mainly by a nitric oxide-mediated mechanism. (Review) PMID: 28606038
    5. a novel fusion transcript comprising the RLN1 and RLN2 genes, was identified. PMID: 26499396
    6. Although serum relaxin level is not a causative factor for benign hypermobility syndrome, the significant increases in patients with hyperkyphosis and pes planus suggest the hypothesis that relaxin has a limited and indefinite role in patients with BJHS. PMID: 25322737
    7. Serum concentrations of relaxin showed a positive association to duration of gestation among women with miscarriage but no association to duration of gestation among women with spontaneous onset of labour. PMID: 26272327
    8. Rln enhanced synergistically BMP-2-induced osteoblast differentiation and bone formation. PMID: 24643989
    9. Relaxin actions in pregnancy include increasing cervical pro-MMP-1 and pro-MMP-3 and decreasing TIMP-1, changes which soften the cervix. PMID: 24640561
    10. For the first time, we bring together the systemic (ovarian) and autocrine/paracrine (intrauterine) sources of RLN, in an attempt to understand how RLN contributes to premature birth in women. PMID: 24640563
    11. Notch signaling can down-regulate TGF-beta1/Smad3-induced fibroblast-myofibroblast transition and that RLX could exert its well known anti-fibrotic action through the up-regulation of this pathway. PMID: 23704950
    12. Recombinant human relaxin (RLX) may provide a novel therapy to manage atrial fibrillation in humans by reversing fibrosis and hypertrophy and by modulating cardiac ionic currents. PMID: 23748429
    13. relaxin may promote the proliferation, invasion and metastasis of osteosarcoma cells by regulating the expression of MMP-9 and facilitating ECM degradation. PMID: 23661525
    14. [review] This study not only clarifies the role of relaxin in sperm, but could also open avenues of research into its use in fertility treatment. PMID: 22180889
    15. heterozygous loss at the RLN1 locus is not a genetic factor mediating high population-wide risk for testicular germ cell tumour, but do not exclude a contribution of this aberration in some cases of cancer PMID: 21696394
    16. Endometrial expression of relaxin and its receptor in endometriosis. PMID: 20655530
    17. In conclusion, we have identified S100A4 as a major mediator of the actions of relaxin in thyroid carcinoma cell motility and in vivo thyroid tumor angiogenesis. PMID: 20332215
    18. Relaxin is a potent stimulator of osteoclastogenesis from hematopoietic precursors and regulates the activity of mature osteoclasts. PMID: 19833242
    19. Women with a history of recurrent pregnancy loss demonstrate attenuated levels of serum relaxin across all pregnancy trimesters. PMID: 19695764
    20. demonstrated that prorelaxin has the ability to facilitate cell migration processes exclusive of its ability to stimulate cell proliferation PMID: 12865351
    21. Data describe the conformation of the relaxin-binding site of the leucine-rich G-protein-coupled receptor 7. PMID: 15695505
    22. results suggest that relaxin may contribute to follicle development through the mechanism of angiogenesis in the ovary PMID: 15956699
    23. rhRLX increases cardiac output and reduces arterial load irrespective of gender PMID: 15956701
    24. In naturally occurring cycles, increased serum relaxin is associated with augmented renal hemodynamics PMID: 15956702
    25. roles of the relaxin system in three potential causes of preterm birth are discussed PMID: 15956731
    26. human relaxin may accelerate the early stages of orthodontic tooth movement in rats PMID: 15956736
    27. relaxin-like hormones appear to be present early during C-cell hyperplasia and potentially functional relaxin/INSL3 ligand-receptor systems are present in human medullary thyroid carcinoma tissues and cell lines PMID: 15956746
    28. rhRLX increases cardiac output and reduces arterial load in hypertensive rats without reducing blood pressure. Time of response is dependent on model of hypertension. Rats with angiotensin II hypertension responded more rapidly to rhRLX than SHR. PMID: 16172427
    29. Relaxin stimulates leukocyte adhesion and migration through a relaxin receptor LGR7-dependent mechanism PMID: 16303766
    30. Relaxin signaling plays a role in prostate cancer progression. PMID: 17363522
    31. Relaxin signalling in THP-1 cells uses a novel phosphotyrosine-dependent pathway. PMID: 17509748
    32. Relaxin was positively related to insulin sensitivity and negatively to beta-cell function. Logistic regression analysis revealed that the correlation between relaxin and HOMA2 remained significant after adjustment for age, BMI. PMID: 18035445
    33. long-term exposure to relaxin confers growth inhibitory and anti-invasive properties in oestrogen-independent tumours in vivo, which may in part be mediated through a down-regulation of S100A4 PMID: 18718015
    34. RXFP1-inactive relaxin activates human glucocorticoid receptor. PMID: 19101597
    35. The hydrogen-bond network and electrostatic interactions between charged groups in INSL5 by NMR-monitored temperature and pH titrations was characterized. PMID: 19178384
    36. The antitumor effect of Rlx was mediated through degradation of tumor stroma, which provided increased access of infiltrating antitumor immune cells to their target tumor cells. PMID: 19329780
    37. decidual RLN expression is independent of lipopolysaccharide but may induce a local sterile inflammatory process which potentially contributes to extracellular matrix degradation and weakening of the fetal membranes PMID: 19467703
    38. There were no correlation between relaxin concentrations and the cervical length, indicating that relaxin is probably not the cause of preterm shortening of the cervix PMID: 19481729
    39. Relaxin 1 is a candidate gene controlling lung function development in mice. PMID: 17804602

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Insulin family
  • 组织特异性：
    Prostate. Not expressed in placenta, decidua or ovary.
  • 数据库链接：

    HGNC: 10026

    OMIM: 179730

    KEGG: hsa:6013

    STRING: 9606.ENSP00000223862

    UniGene: Hs.368996