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  4. Recombinant Human tRNA N6-adenosine threonylcarbamoyltransferase (OSGEP)

Recombinant Human tRNA N6-adenosine threonylcarbamoyltransferase (OSGEP)

In Stock
  • 中文名称：
    人OSGEP重组蛋白
  • 货号：
    CSB-EP878842HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    OSGEP
  • Uniprot No.：
  • 别名：
    FLJ20411; GCPL-1; GCPL1; hOSGEP; KAE1; O sialoglycoprotein endopeptidase; OSGEP; OSGEP_HUMAN; OSGEP1; Pasteurella haemolytica metalloprotease homolog with glycoprotein substrates/gpc-like protein 1; Probable O sialoglycoprotein endopeptidase; Probable tRNA threonylcarbamoyladenosine biosynthesis protein osgep; PRSMG1; Prsmg1/Gcpl1; t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgep
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    63.4kDa
  • 表达区域：
    1-335aa
  • 氨基酸序列
    MPAVLGFEGSANKIGVGVVRDGKVLANPRRTYVTPPGTGFLPGDTARHHRAVILDLLQEALTESGLTSQDIDCIAYTKGPGMGAPLVSVAVVARTVAQLWNKPLVGVNHCIGHIEMGRLITGATSPTVLYVSGGNTQVIAYSEHRYRIFGETIDIAVGNCLDRFARVLKISNDPSPGYNIEQMAKRGKKLVELPYTVKGMDVSFSGILSFIEDVAHRMLATGECTPEDLCFSLQETVFAMLVEITERAMAHCGSQEALIVGGVGCNVRLQEMMATMCQERGARLFATDERFCIDNGAMIAQAGWEMFRAGHRTPLSDSGVTQRYRTDEVEVTWRD
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal GST-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
  • 基因功能参考文献：
    1. Mutation in KAE1 interfering with global protein production was identified in two patients with developmental delay, renal defect and hypomagnesemia. PMID: 28272532
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    KAE1 / TsaD family
  • 组织特异性：
    Widely expressed at low level. Expressed in heart, placenta, liver, kidney, lung, brain, skeletal muscle and pancreas.
  • 数据库链接：

    HGNC: 18028

    OMIM: 610107

    KEGG: hsa:55644

    STRING: 9606.ENSP00000206542

    UniGene: Hs.525196