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  4. Recombinant Human Probable palmitoyltransferase ZDHHC8 (ZDHHC8), partial

Recombinant Human Probable palmitoyltransferase ZDHHC8 (ZDHHC8), partial

  • 中文名称：
    人ZDHHC8重组蛋白
  • 货号：
    CSB-YP890747HU1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ZDHHC8重组蛋白
  • 货号：
    CSB-EP890747HU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ZDHHC8重组蛋白
  • 货号：
    CSB-EP890747HU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ZDHHC8重组蛋白
  • 货号：
    CSB-BP890747HU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ZDHHC8重组蛋白
  • 货号：
    CSB-MP890747HU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZDHHC8
  • Uniprot No.：
  • 别名：
    ZDHHC8; KIAA1292; ZDHHCL1; ZNF378; Palmitoyltransferase ZDHHC8; Zinc finger DHHC domain-containing protein 8; DHHC-8; Zinc finger protein 378
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes. Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux. Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane. Could also play a role in glutamatergic transmission.
  • 基因功能参考文献：
    1. the association between the COMT Val158Met and ZDHHC8 rs175174 single nucleotide polymorphism and the susceptibility to schizophrenia through a case-control study involving a population from the North Region of Brazil, was investigated. PMID: 28562378
    2. These data suggest that ZDHHC8 may play a role in cortical volumes in patients with schizophrenia. PMID: 23403413
    3. increased corpus callosum volume in children with 22q11DS is associated with ZDHHC8 polymorphism. PMID: 22763378
    4. Consistently negative associations with schizophrenia were found in the rs175174 polymorphism PMID: 20661937
    5. The present study provides the first evidence that ZDHHC8 polymorphisms on the 22q11 locus are associated with smooth pursuit eye movement (SPEM)abnormality in a Korean population. PMID: 20468065
    6. genotyped three genetic variants within the ZDHHC8 locus and conducted association studies in both population- and family-based samples of the Han Chinese population PMID: 15489219
    7. Because our sample size provided quite high power, ZDHHC8 may not play a major role in Japanese schizophrenia and our results did not support the gender-specific effect of this SNP. PMID: 15631889
    8. Single nucleotide polymorphism is not associated with chromosome 22 deletion or schizophrenia. PMID: 17728672

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  • 亚细胞定位：
    Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
  • 蛋白家族：
    DHHC palmitoyltransferase family, ERF2/ZDHHC9 subfamily
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 18474

    OMIM: 608784

    KEGG: hsa:29801

    STRING: 9606.ENSP00000384716

    UniGene: Hs.63128