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  4. Recombinant Human Poliovirus receptor-related protein 3 (PVRL3), partial

Recombinant Human Poliovirus receptor-related protein 3 (PVRL3), partial

  • 中文名称：
    人NECTIN3重组蛋白
  • 货号：
    CSB-YP882076HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NECTIN3重组蛋白
  • 货号：
    CSB-EP882076HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NECTIN3重组蛋白
  • 货号：
    CSB-EP882076HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NECTIN3重组蛋白
  • 货号：
    CSB-BP882076HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NECTIN3重组蛋白
  • 货号：
    CSB-MP882076HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CD113; CDw113; DKFZP566B0846; FLJ90624; Nectin-3; Nectin3; Poliovirus receptor related 3; Poliovirus receptor related protein 3; Poliovirus receptor-like 3; Poliovirus receptor-related protein 3; PPR3; PRR3; Pvrl3; PVRL3_HUMAN; PVRR3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
  • 基因功能参考文献：
    1. Nectin-3 mutation in men with severe teratospermia PMID: 28689229
    2. Data suggest that 3 independent regions of TcdB (Clostridium difficile toxin B; 1372-1493, 1493-1848, 1851-2366) contribute to binding and entry of TcdB into mammalian cells; residues 1372-1493 are sufficient for interaction with PVRL3. PMID: 26602083
    3. Expression of nectin-3 in pancreatic cancer can be a prognostic factor. PMID: 25690753
    4. PVRL3 is a physiologically relevant binding partner that can serve as a target for the prevention of TcdB-induced cytotoxicity in C. difficile infection. PMID: 26038560
    5. Nectin-3 is associated with the formation of cell junctions and be a putative suppressor molecule to the invasion of breast cancer cells. PMID: 24386110
    6. Nectin-3 trans-interacts with Nectin-2 to promote lymphocyte and monocyte extravasation. PMID: 24116228
    7. Data suggest that expression of nectin-3 is up-regulated in eutopic endometrium of patients with endometriosis as compared with control subjects and up-regulated in all endometriotic lesions investigated compared with eutopic endometrium. PMID: 22926846

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  • 亚细胞定位：
    Cell membrane; Single-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane.
  • 蛋白家族：
    Nectin family
  • 组织特异性：
    Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.
  • 数据库链接：

    HGNC: 17664

    OMIM: 607147

    KEGG: hsa:25945

    STRING: 9606.ENSP00000418070

    UniGene: Hs.293917