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  4. Recombinant Human Phosphatidylethanolamine-binding protein 1 (PEBP1)

Recombinant Human Phosphatidylethanolamine-binding protein 1 (PEBP1)

  • 中文名称：
    人PEBP1重组蛋白
  • 货号：
    CSB-YP017766HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PEBP1重组蛋白
  • 货号：
    CSB-EP017766HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PEBP1重组蛋白
  • 货号：
    CSB-EP017766HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PEBP1重组蛋白
  • 货号：
    CSB-BP017766HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PEBP1重组蛋白
  • 货号：
    CSB-MP017766HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PEBP1
  • Uniprot No.：
  • 别名：
    Epididymis luminal protein 210; Epididymis secretory protein Li 34; Epididymis secretory protein Li 96; HCNP; HCNPpp; HEL 210; HEL S 34; HEL S 96; Hippocampal cholinergic neurostimulating peptide; Neuropolypeptide h3; PBP; PEBP ; PEBP 1; PEBP-1; Pebp1; PEBP1_HUMAN; Phosphatidylethanolamine binding protein ; Phosphatidylethanolamine binding protein 1; Prostatic binding protein ; Prostatic-binding protein; R kip; Raf kinase inhibitor protein; Raf kinase inhibitory protein; RKIP
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-187
  • 氨基酸序列
    PVDLSKWSG PLSLQEVDEQ PQHPLHVTYA GAAVDELGKV LTPTQVKNRP TSISWDGLDS GKLYTLVLTD PDAPSRKDPK YREWHHFLVV NMKGNDISSG TVLSDYVGSG PPKGTGLHRY VWLVYEQDRP LKCDEPILSN RSGDHRGKFK VASFRKKYEL RAPVAGTCYQ AEWDDYVPKL YEQLSGK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.; HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.
  • 基因功能参考文献：
    1. Low RKIP Expression is associated with asthma. PMID: 30282734
    2. our studies demonstrate how KRAS inhibits the tumor suppressor RKIP, thus offering novel justification for targeting RKIP as a strategy to overcome KRAS-induced tumor metastasis and chemoresistance in PDAC. PMID: 29315556
    3. RKIP expression in gastrointestinal stromal tumors is associated with tumor size, NIH risk grade, and mucosal invasion, and low or no expression of RKIP predicts a high malignancy potential. PMID: 29930472
    4. Octreotide may weaken invasion and metastasis through the upregulation of PEBP1. Octreotide may reduce the risk of recurrence and metastasis after surgery for liver cancer. PMID: 29990987
    5. Knockdown of RKIP increased phosphorylated ERK and thus suppressed sorafenib-mediated cell death. PMID: 29858683
    6. Baseline urinary RKIP, evaluated in an independent cohort of 56 Clear cell Renal Cell Carcinoma patients and 28 healthy subjects, successfully distinguished both groups and, most importantly, a cut-off value of 10 ng/mg/g Pr/uCr enabled a highly accurate prediction of Cancer-specific survival and Progression-free survival. PMID: 28418894
    7. we found that the RKIP expression was decreased significantly in HBV infected tumor tissues compared to normal adjacent tissues, suggesting the reduction or absence of RKIP expression was closely related to liver carcinogenesis. PMID: 27902472
    8. downregulation of RKIP plays an important role in the breast neoplastic progression and correlates with poor prognosis in patients with breast carcinoma (BC). Aberrant RKIP methylation is one of the mechanisms that lead to downregulation of RKIP in BC. PMID: 26894644
    9. can act as a negative mediator in autophagy through stimulation of the AKT-MTORC1 pathway and direct interaction with LC3. PMID: 27540684
    10. PEBP1, a scaffold protein inhibitor of protein kinase cascades, complexes with two 15LO isoforms, 15LO1 and 15LO2, and changes their substrate competence to generate hydroperoxy-phosphatidylethanolamines (PE). Inadequate reduction of hydroperoxy-PE due to insufficiency or dysfunction of a selenoperoxidase, GPX4, leads to ferroptosis. PMID: 29053969
    11. miR-23a as a negative regulator of RKIP expression in AML. PMID: 27197200
    12. Knockdown of RKIP promotes LX-2 cell proliferation. PMID: 28031115
    13. RKIP contributes to colitis development by promoting inflammation and mediating intestinal epithelial cell apoptosis. PMID: 26801887
    14. The study demonstrates that miR-543 promotes the proliferation and metastasis of prostate cancer via targeting RKIP. PMID: 28245474
    15. RKIP inhibitors locostatin reduces extracellular matrix production as well as the migration and proliferation of myometrial and leiomyoma cells. PMID: 27565262
    16. RKIP has a role in suppressing proliferation and metastasis of breast cancer cell lines through up-regulation of miR-185 targeting HMGA2 PMID: 27651238
    17. positive p-Ser153 RKIP expression is a favorable prognostic factor and affects clinical response to radiotherapy in nasopharyngeal carcinoma PMID: 27647315
    18. Expression of RKIP is closely correlated with the survival of pancreatic cancer patients. RKIP can inhibit pancreatic adenocarcinoma cells proliferation, activities of migration and invasion, through downregulating Raf-1-MEK1/2-ERK1/2 signaling pathway. PMID: 27444299
    19. RKIP expression is negatively associated with tumor metastasis in gastric cancer. PMID: 25764514
    20. s demonstrate that the inhibition of the CCL5 expression is the cause of the observed effects resulting from RKIP expression. Results underscore the significance of RKIP as important negative regulator of tumor microenvironment. PMID: 26375811
    21. report of the expression profile of RKIP in a heterogeneous group of soft tissue sarcomas; findings showed that only a small subset of cases exhibited RKIP loss, yet its loss is an independent biomarker of prognosis PMID: 26859895
    22. RKIP inhibits glioma cell migration and invasivess by inhibiting MMP2/MMP9/HMAG2 expression. PMID: 26823735
    23. Loss of RKIP is associated with neoplasms. PMID: 26716415
    24. Downregulation or depletion of RKIP was related to the onset and progression of esophageal squamous cell carcinoma, and facilitated the invasion and metastasis of ESCC by downregulating E-cadherin and upregulating NF-kB p65. PMID: 26617724
    25. Identify intestinal RKIP as capable of hydrolyzing prasugrel to its thiolactone metabolite. PMID: 26558823
    26. Study indicates that reduced RKIP expression is correlated with metastasis and recurrence of disease in stage II colorectal cancer (CRC) suggesting it as an important metastasis-suppressor gene in CRC. PMID: 26238523
    27. RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13 PMID: 26308852
    28. Results suggest that up-regulation of miR-27a could suppress RKIP expression and in turn contribute to chemoresistance of lung adenocarcinoma cells to cisplatin. PMID: 25128483
    29. Raf kinase inhibitor protein mediated signaling inhibits invasion and metastasis of hepatocellular carcinoma. PMID: 26116914
    30. RKIP is a metastatic suppressor and predictor for metastasis and prognosis in nasopharyngeal carcinoma, and RKIP downregulation promotes nasopharyngeal carcinoma invasion, metastasis and epithelial to mesenchymal transition by activating Stat3 signaling PMID: 25915430
    31. The upregulated expression of RKIP in colorectal cancer cells inhibited cell invasion and metastasis, while downregulation of RKIP reduced chemosensitivity by inhibiting apoptosis induced by HCPT. PMID: 26177829
    32. This study showed that elevated amygdala HCNP-pp expression may contribute to mechanisms of major depression in women. PMID: 25819500
    33. RKIP is upregulated in heart failure. PMID: 26479924
    34. In triple negative breast cancer, RKIP regulates tumor-associated macrophage recruitment by blocking HMGA2, resulting in reduced expression of numerous macrophage chemotactic factors, including CCL5. PMID: 26238785
    35. downregulation of RKIP occurs frequently... suggesting RKIP being a critical tumor suppressor for clear cell renal cell carcinomas PMID: 25277181
    36. Loss of RKIP expression was associated with unfavorable OS. PMID: 25171481
    37. Data suggest that RKIP inhibits gastric cancer metastasis via the downregulation of its downstream target genes STAT3 and cyclin D1. PMID: 25337233
    38. functional RKIP rs17512051 polymorphism may affect ccRCC susceptibility PMID: 25329396
    39. Raf kinase inhibitor protein expression is a suitable and easily determinable marker in the primary tumour that could predict the risk of uveal melanoma to metastasize PMID: 24763848
    40. s demonstrate that the N-terminus of human Raf1 kinase (hRaf11-147aa) binds with human RKIP (hRKIP) at its ligand-binding pocket, loop "127-149", and the C-terminal helix by nuclear magnetic resonance experiments. PMID: 24863296
    41. RKIP inhibits gastric cancer cell survival and invasion by regulating the expression of HMGA2 and OPN. PMID: 25172097
    42. Fine control of RKIP activity and regulation is crucial to avoid pathological processes, such as metastasis,pulmonary arterial hypertension, and heart failure.[review] PMID: 25597351
    43. Genetic an epigenetic control of RKIP transcription and review of known mechanisms employed by different types of chemotherapeutic agents to activate RKIP expression in cancer cells.[review] PMID: 25597352
    44. This brief review describes the role of RKIP in the regulation of drug sensitivity via disruption of the NF-kappaB/Snail/ YY1/RKIP loop that regulates resistance in cancer cells. [review] PMID: 25597353
    45. Here, we review RKIP's role as a metastasis suppressor and the signaling networks and genes regulated by RKIP in metastatic, triple-negative breast cancer. [review] PMID: 25597354
    46. RKIP loss is a frequent occurrence in many solid tumor cancers and may serve as a viable prognostic biomarker. [review] PMID: 25597355
    47. Here, we present a three-state model to explain the RKIP functional switch and discuss the role of the pocket loop in regulating RKIP activity. [review] PMID: 25597357
    48. RKIP synergizes with microtubule inhibitors to induce apoptosis and inhibit STAT3 activation of breast and prostate cancer cells. RKIP plays a critical role in opposing the effects of pro-oncogenic STAT3 activation. PMID: 24658061
    49. overexpression of RKIP could decrease the proliferation and increase the apoptosis of K562 cells. PMID: 25015191
    50. down-regulation of RKIP expression was observed in human gastric cell lines, and miR-224 could negatively regulate the expression and biological characteristics of RKIP, contributing to suppress the proliferation and invasion of gastric cells. PMID: 25017365

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Phosphatidylethanolamine-binding protein family
  • 数据库链接：

    HGNC: 8630

    OMIM: 604591

    KEGG: hsa:5037

    STRING: 9606.ENSP00000261313

    UniGene: Hs.433863