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  4. Recombinant Human Perilipin-1 (PLIN1), partial

Recombinant Human Perilipin-1 (PLIN1), partial

  • 中文名称：
    人PLIN1重组蛋白
  • 货号：
    CSB-EP526447HU2
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PLIN1重组蛋白
  • 货号：
    CSB-EP526447HU2-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PLIN1重组蛋白
  • 货号：
    CSB-BP526447HU2
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PLIN1重组蛋白
  • 货号：
    CSB-MP526447HU2
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Name:PLIN1Synonyms:PERI, PLIN
  • Uniprot No.：
  • 别名：
    Lipid droplet associated protein; Lipid droplet-associated protein; PERI; Perilipin A; Perilipin; Perilipin-1; PerilipinA; PLIN; PLIN1; PLIN1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.
  • 基因功能参考文献：
    1. Classification of cells as containing few large or many small LDs followed by calculating the percentage of cells in each class proved to discriminate the positive PLIN1-suppressed phenotype from the untreated negative control with an area under the receiver operating characteristic curve of 0.98. PMID: 29031005
    2. Expression of UCP2 and PLIN1 genes influences the resting metabolic rate in obese individuals and could predict the weight loss after bariatric surgery. PMID: 27376365
    3. The PLIN 6 polymorphism of the perilipin gene may influence the risk of obesity during adolescence. PMID: 28274232
    4. Variability at the PLIN1 locus is associated with variability in weight loss. Moreover, eating late is related to lower weight-loss effectiveness among carriers of the AA genotype at the PLIN1 14995A>T variant. PMID: 27629052
    5. The strong association of PLIN1, CFD and ADIPOQ genes with adipogenesis prompted s to study the influence the bone health status as evaluated by quantitative ultrasound (QUS) bone densitometer in a North Indian cohort. Overall, ADIPOQ (rs1501299 and rs3774261) and combined cluster of PLIN1 rs2304796 and rs2304795) and CFD (rs1683563) demonstrated correlation. PMID: 28189761
    6. Perilipin 1 expression increased with adipocytic differentiation of liposarcoma subtypes showing statistical significance. PMID: 27646609
    7. Based on the PCR with mismatched primers PLIN1 polymorphisms could be identified effectively in Chinese Han population. PMID: 27468581
    8. Conserved amphipathic helices mediate lipid droplet targeting of PLIN1, PLIN2, and PLIN3. PMID: 26742848
    9. Skeletal muscle PLIN proteins likely play a role in the hydrolysis of triglycerides stored in lipid droplets and the passage of fatty acids to the mitochondria for oxidation. PMID: 25971423
    10. The functional PLIN1 rs6496589 may influence the risk of central obesity through possible regulation of lipid storage. PMID: 25529448
    11. After bariatric surgery-induced weight loss, PLIN1 gene/protein expression in SAT increased significantly. Findings suggest a positive functional interaction between PLIN1 & mitochondrial biogenesis-related genes in human adipose tissue. PMID: 24126816
    12. Use of molecular docking software to design perilipin-1 inhibitors as antiobesity agents. PMID: 24610610
    13. This plin1 variant binds and stabilizes ABHD5 expression but still fails to inhibit basal lipolysis as effectively as wild-type perilipin 1. PMID: 25114292
    14. In long-term steatosis models in vitro, TIP47, MLDP, adipophilin, and finally perilipin were gradually induced PMID: 24269473
    15. Independently and in an interactive manner, PLIN (and ENPP1) contribute to the risk of type 2 diabetes in a Taiwanese population. PMID: 23111648
    16. Chinese adults with high waist circumference may have a high risk of diabetes, especially those with allele T in rs1052700 or with allele A in rs894160 of perilipin gene and those with perilipin genotype AA (rs894160) may have a high risk of obesity. PMID: 23517113
    17. Although specific for invasive sebaceous carcinoma, perilipin expression was not helpful in distinguishing sebaceous carcinoma in situ from squamous cell carcinoma in situ with clear cell change. PMID: 23642680
    18. Perilipin is almost exclusively expressed in white adipocytes, so the serious metabolic sequelae observed in patients suggest that primary defects in adipose tissue can lead to all the typical features seen in patients with the metabolic syndrome.[review] PMID: 23392103
    19. PKC activation is required for TSH-stimulated perilipin phosphorylation and lipolysis in differentiated adipocytes. PMID: 22730012
    20. Reduced mRNA and protein content of Plin and G0S2 and borderline increased ATGL protein in sc adipose tissue from poorly controlled type 2 diabetic subjects. PMID: 22535977
    21. The morning cortisol increase as indicated by CAR correlated positively and significantly with hPER1 gene expression in older women suggesting that hPER1 expression increases in response to the morning cortisol increase in older women PMID: 22580060
    22. genetic association studies in populations in US Midwest (MN, UT): When ratio of saturated fat to carbohydrate is high in diet, plasma insulin and insulin resistance are higher in women who are carriers of the minor allele in a PLIN1 SNP (rs894160). PMID: 21193293
    23. genetic association studies in obese women in Spain (gene-diet interactions): Women on reducing diet who carry 11482(G>A) A allele have lower reduction in waist circumference and greater decrease in lipid oxidation rate than non-A allele carriers. PMID: 21392418
    24. Identified two heterozygous frameshift mutations in the perilipin gene (PLIN1) in three families with partial lipodystrophy, severe dyslipidemia, and insulin-resistant diabetes; findings define a novel dominant form of inherited lipodystrophy. PMID: 21345103
    25. a novel role for perilipin expression in adipose tissue metabolism and regulation of obesity and its metabolic complications PMID: 19797618
    26. The present study aimed at comparing expression and subcellular distribution of perilipin and hormone-sensitive lipase in two abdominal adipose tissues of lean and obese women. PMID: 20017959
    27. Expression patterns of perilipin and adipophilin in nonalcoholic fatty liver disease livers vary with the size of lipid droplets PMID: 20032580
    28. This study found no incrased risk of obesity in Chinese Han adults with a single nucleotide polymorphism of perilipin. PMID: 20163070
    29. Variation in PLIN may affect glucose and lipid metabolism in women both with and without ariation in PLIN may affect glucose and lipid metabolism in women both with and without polycystic ovary syndrome. PMID: 19782423
    30. Perilipin could be a factor behind impaired lipolysis in insulin-resistants sconditions. PMID: 12802495
    31. perilipin was elevated in obese subjects, perhaps as a compensatory mechanism to limit basal lipolysis. PMID: 15001633
    32. Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women PMID: 15355432
    33. study suggested a significant contribution of perilipin(PLIN) polymorphism 1243 to the elevated total cholesterol (TC) levels indicating that PLIN gene may be involved in human lipid metabolism PMID: 15601966
    34. data support the hypothesis that the perilipin(PLIN) locus may be a significant genetic determinant for obesity risk in whites and that women are more sensitive to the genetic effects of perilipin than men PMID: 15601970
    35. The association of increased obesity risk and structure of PLIN gene is studied; results support the role of the PLIN locus as an ethnically dependent modulator of obesity risk in humans. PMID: 15770500
    36. We show the presence and induction of perilipin in atheroma. PMID: 15961705
    37. PLIN11482A carriers were resistant to weight loss, suggesting that this polymorphism may predict outcome of BW reduction strategies based on low-energy diets. PMID: 15985482
    38. Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase PMID: 16243839
    39. Cooperation with other transcription factors may be differentially involved in selective transactivation of the perilipin gene by different peroxisome proliferator-activated receptor subtypes. PMID: 16567422
    40. PLIN 11482G-->A/14995A-->T polymorphisms modulate the association between SFAs/carbohydrate in diet and insulin resistance in Asian women. PMID: 16732014
    41. Genetic variations in the perilipin gene can affect weight gain associated with rosiglitazone treatment in patients with type 2 diabetes. PMID: 16732015
    42. Results suggest that that PLIN constitutes a susceptibility locus for reduced BMD in Japanese men. PMID: 16786163
    43. The rs4578621 and rs894160 polymorphisms of the perilipin gene are not major genetic determinants of obesity and type 2 diabetes-related phenotypes in a random sample of French men and women. PMID: 16836753
    44. PLIN is a candidate gene for obesity risk in humans as well as a modulator of dietary response to therapies aimed to reduce body weight and decrease metabolic syndrome risk. [REVIEW] PMID: 17353663
    45. Perilipin content decreased and adipophilin increased with lipoprotein lipid loading regardless of intracellular neutral lipid composition PMID: 17927964
    46. negative finding that the common variants of PLIN do not have a major effect on susceptibility to stroke in a Chinese population PMID: 18174481
    47. The results of these studies demonstrated that A. phagocytophilum modulates lipid metabolism by increasing PLIN mRNA levels and facilitates infection of HL-60 cells. PMID: 18201980
    48. Thus, the perilipin gene expression is regulated by a transcriptional network controlling energy metabolism, substantiating the functional importance of perilipin in the maintenance of body energy balance. PMID: 18243128
    49. These 2 studies suggest that the presence of the minor C and A alleles at PLIN1 and PLIN4, respectively, are associated with a lower postprandial response that may result in lower atherogenic risk for these persons PMID: 18326614
    50. Central obesity may modify the associations between PLIN variations and diabetes risk in women. PMID: 18356850

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  • 相关疾病：
    Lipodystrophy, familial partial, 4 (FPLD4)
  • 亚细胞定位：
    Endoplasmic reticulum. Lipid droplet.
  • 蛋白家族：
    Perilipin family
  • 组织特异性：
    Detected in adipocytes from white adipose tissue (at protein level). Detected in visceral adipose tissue and mammary gland.
  • 数据库链接：

    HGNC: 9076

    OMIM: 170290

    KEGG: hsa:5346

    STRING: 9606.ENSP00000300055

    UniGene: Hs.103253