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  4. Recombinant Human Paired mesoderm homeobox protein 1 (PRRX1)

Recombinant Human Paired mesoderm homeobox protein 1 (PRRX1)

  • 中文名称：
    人PRRX1重组蛋白
  • 货号：
    CSB-YP018807HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PRRX1重组蛋白
  • 货号：
    CSB-EP018807HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PRRX1重组蛋白
  • 货号：
    CSB-EP018807HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PRRX1重组蛋白
  • 货号：
    CSB-BP018807HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PRRX1重组蛋白
  • 货号：
    CSB-MP018807HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PRRX1
  • Uniprot No.：
  • 别名：
    AGOTC; Homeobox protein PHOX1; Paired mesoderm homeo box 1; Paired mesoderm homeobox 1; paired mesoderm homeobox 1 isoform pmx-1b; Paired mesoderm homeobox protein 1; Paired related homeobox 1; Paired related homeobox protein 1; Paired-related homeobox protein 1; PHOX 1; PHOX1 1, 2; PHOX1; PMX 1; PMX1; PRRX 1; Prrx1; PRRX1_HUMAN; PRX 1 ; PRX-1; PRX1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-245
  • 氨基酸序列
    MTSSYGHVLE RQPALGGRLD SPGNLDTLQA KKNFSVSHLL DLEEAGDMVA AQADENVGEA GRSLLESPGL TSGSDTPQQD NDQLNSEEKK KRKQRRNRTT FNSSQLQALE RVFERTHYPD AFVREDLARR VNLTEARVQV WFQNRRAKFR RNERAMLANK NASLLKSYSG DVTAVEQPIV PRPAPRPTDY LSWGTASPYS AMATYSATCA NNSPAQGINM ANSIANLRLK AKEYSLQRNQ VPTVN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer.
  • 基因功能参考文献：
    1. Low PRRX1 expression is associated with hepatocellular carcinoma. PMID: 28677793
    2. identified a functional genetic variant that alters PRRX1 expression, ultimately resulting in electrophysiological alterations in atrial myocytes that may promote Atrial fibrillation. PMID: 28974514
    3. The glioma-initiating cells self-renewal function regulated by PRRX1 is mediated by dopamine D2 receptor (DRD2). PRRX1 directly binds to the DRD2 promoter and transactivates its expression in glioma-initiating cells. PMID: 28486630
    4. LGR5-expressing fraction of CD54+ cells represents gastric cancer CSCs, in which LGR5 is closely associated with stemness and EMT core genes PMID: 28033430
    5. Prrx1b may be an important regulator of epithelial-mesenchymal transition in Triple-negative breast cancer cells. PMID: 27027510
    6. miR-655 inhibits the acquisition of the epithelial-mesenchymal transition phenotype in triple-negative breast cancer by down-regulating Prrx1, thereby inhibiting cell migration and invasion during cancer progression. PMID: 26820102
    7. Decreased Expression of PRRX1 was Associated with Hepatocellular Carcinoma. PMID: 25404478
    8. the switch from Prrx1b to Prrx1a governs EMT plasticity in both mouse models of PDAC and human PDAC PMID: 26773005
    9. These findings demonstrate that PRRX1 promotes epithelial-mesenchymal transition in gastric cancer cells PMID: 25428393
    10. Our results indicate that activation of Notch signaling by PRRX1 is associated with the promotion of glioblastoma cell invasion. PMID: 25522823
    11. We conclude that miR-146b-5p has a role in cell proliferation and invasion, and that PRRX1 plays an important role in papillary thyroid carcinoma epithelial-mesenchymal transition and disease progression. PMID: 24946010
    12. Overexpression of PRRX1 in stably overexpressed-miR-124 cell lines could rescue the effects of radiosensitivity enhancement brought by miR-124. PMID: 24705396
    13. In the rare variant joint analysis, damaging variants within the PRRX1 region showed significant association with AF. PMID: 24239840
    14. PRRX1 is an indicator of metastasis and poor prognosis in colorectal cancer cases. PMID: 23807160
    15. The homeobox factor Prrx1 is an EMT inducer conferring migratory and invasive properties. PMID: 23201163
    16. We show that the homeobox factor Prrx1 is an EMT inducer conferring migratory and invasive properties. The loss of Prrx1 is required for cancer cells to metastasize in vivo, which revert to the epithelial phenotype concomitant with the acquisition of stem cell properties. PMID: 23201163
    17. Mutation analysis was performed after sequencing the entire coding regions of OTX2 and PRRX1 genes isolated from the proband and his parents. After thorough analysis, no DNA variations were detected. PMID: 22198066
    18. identification of the two Prx1 target genes, which play a pivotal role in development of liver fibrosis, is a novel finding for liver pathophysiology PMID: 18296734

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  • 相关疾病：
    Agnathia-otocephaly complex (AGOTC)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family
  • 数据库链接：

    HGNC: 9142

    OMIM: 167420

    KEGG: hsa:5396

    STRING: 9606.ENSP00000239461

    UniGene: Hs.283416