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Recombinant Human Otolin-1 (OTOL1)

  • 中文名称：
    人OTOL1重组蛋白
  • 货号：
    CSB-YP407389HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人OTOL1重组蛋白
  • 货号：
    CSB-EP407389HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人OTOL1重组蛋白
  • 货号：
    CSB-EP407389HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人OTOL1重组蛋白
  • 货号：
    CSB-BP407389HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人OTOL1重组蛋白
  • 货号：
    CSB-MP407389HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    OTOL1
  • Uniprot No.：
  • 别名：
    OTOL1; Otolin-1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-477
  • 氨基酸序列
    KTTPHTK FTKKSEEREM PKGLKPSSGP PPEEEETLFT EMAEMAEPIT KPSALDSVFG TATLSPFENF TLDPADFFLN CCDCCSPVPG QKGEPGETGQ PGPKGEAGNL GIPGPPGVVG PQGPRGYKGE KGLKGERGDQ GVPGYPGKPG AQGEPGPKGD KGNIGLGGVK GQKGSKGDTC GNCTKGEKGD QGAMGSPGLH GGPGAKGEKG EMGEKGEMGD KGCCGDSGER GGKGQKGEGG MKGEKGSKGD SGMEGKSGRN GLPGAKGDPG IKGEKGELGP PGLLGPTGPK GDIGNKGVRG PTGKKGSRGF KGSKGELARV PRSAFSAGLS KPFPPPNIPI KFEKILYNDQ GNYSPVTGKF NCSIPGTYVF SYHITVRGRP ARISLVAQNK KQFKSRETLY GQEIDQASLL VILKLSAGDQ VWLEVSKDWN GVYVSAEDDS IFTGFLLYPE ETSGISP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Collagen-like protein specifically expressed in the inner ear, which provides an organic scaffold for otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Acts as a scaffold for biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OC90, modulates calcite crystal morphology and growth kinetics.
  • 基因功能参考文献：
    1. An expression and purification procedure for the C1q-like domain of human otolin-1 was developed. It forms stable trimers in solution in the presence of calcium ions. C1q-like domains were stabilized by the calcium ions. PMID: 29076638
    2. calcium carbonate crystal growth data demonstrate that Otolin-1 and OC90 modulate in vitro calcite crystal morphology but neither protein is sufficient to produce the shape of otoconia PMID: 24748133
    3. Identification and functional characterization of a similar protein in zebrafish. PMID: 15905077
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    OTOL1 family
  • 数据库链接：

    HGNC: 34071

    KEGG: hsa:131149

    STRING: 9606.ENSP00000330808

    UniGene: Hs.585021