Recombinant Human Nucleobindin-2 protein (NUCB2)

1. Study data identified nesfatin-1 as a key modulator in hypertension and vascular remodeling by facilitating vascular smooth muscle cells phenotypic switching and proliferation. PMID: 29627363
2. intensity of exercise may have an important role in changes of nesfatin-1, leptin, FFA, and epinephrine concentrations even though this was not the case for IL-6 and insulin resistance PMID: 25637303
3. Patients with schizophrenia had significantly higher serum nesfatin-1 levels compared to healthy controls. PMID: 29278806
4. This study finds that soccer matches performed different workout times have strong stimulatory effects on irisin levels in all subjects but nesfatin-1 response varied among the subjects and it did not change significantly in afternoon match. PMID: 30084805
5. serum nesfatin-1 concentrations were inversely correlated with atrial fibrillation development. PMID: 29747779
6. In all trimesters of human pregnancy, NUCB2/nesfatin-1 was highly expressed in syncytiotrophoblast. In addition, there was a significant increase in NUCB2 expression in human primary trophoblast cells induced to syncytialise. PMID: 28855042
7. Data suggest that circulating nesfatin-1 levels are up-regulated in patients newly diagnosed with type 2 diabetes; non-newly diagnosed patients treated with antidiabetic medications exhibit lower circulating nesfatin-1 levels. [META-ANALYSIS, REVIEW] PMID: 29445751
8. Data suggest that levels of nesfatin-1 in maternal serum and cord blood are up-regulated in women with gestational diabetes (GD) as compared to control pregnant women; nesfatin-1 also appears to be up-regulated in subcutaneous abdominal adipose tissue in GD. This study was conducted in China in women of the Han ethnicity. PMID: 28361552
9. expressions of p-Akt/Akt and p-GSK-3beta/GSK-3beta in the myocardium of MI group rats were significantly increased by nesfatin-1 administration, suggesting that nesfatin-1, which appears to possess anti-apoptotic and anti-inflammatory properties, may confer protection against ISO-induced MI via an Akt/GSK-3beta-dependent mechanism. PMID: 28720397
10. Study demonstrated that high expression level of NUCB2 was significantly associated with poor clinical outcome of patient with non-metastatic clear cell renal cell carcinoma. PMID: 27806328
11. The multifunctional biological actions of nesfatin-1 propelled this peptide as a therapeutic target, and as a potential biomarker of diseases. However, a better and comprehensive understanding of tissue specific effects of nesfatin-1 is critical prior to exploring its possible use in the detection and treatment of diseases. PMID: 28137218
12. Data indicate that nesfatin-1/NUCB-2 enhanced migration, invasion and epithelial-mesenchymal transition (EMT) in colon cancer cells through LKB1/AMPK/TORC1/ZEB1 pathways in vitro and in vivo. PMID: 27150059
13. Nesfatin-1 levels decrease following biliopancreatic diversion with duodenal switch-induced weight loss and are significantly associated with parameters of metabolic health. PMID: 27681383
14. women and men showed an inverse association between NUCB2/nesfatin-1 and anxiety with a positive correlation in women and a negative correlation in men. However, no significant change of NUCB2/nesfatin-1 following improvement of anxiety has been observed. PMID: 28273586
15. Our study was the first to investigate the nesfatin 1 levels in patients with the first episode psychosis. Based on our study results, nesfatin 1 might be related to some central nervous system pathologies, including the severity of a psychiatric disorder. PMID: 28814086
16. nucleobindin 2 might play a crucial role in gastric cancer development and could serve as an independent predictor of prognosis of gastric cancer patients. PMID: 28714371
17. Based on the obtained results, it was proposed that ghrelin may be considered as playing a role in the etiopathogenesis of hyperemesis gravidarum that may result in disruption of the relationship between nesfatin-1 and ghrelin. PMID: 27235705
18. This study supports the role of insulin resistance in decreased nesfatin-1 levels in patients with Type 2 diabetes mellitus and metabolic syndrome PMID: 27539099
19. Increased plasma nesfatin-1 concentrations are associated closely with inflammation, trauma severity and clinical outcomes, indicating that nesfatin-1 might be involved in inflammation and become a good prognostic biomarker following traumatic brain injury PMID: 27155585
20. Data suggest that NUCB2 (almost negligible in normal endometrium) plays pivotal roles in cell proliferation and migration/invasiveness of endometrial carcinoma; NUCB2 may serve as a prognostic biomarker for endometrial carcinoma. Expression of NUCB2 appears almost negligible in normal endometrium. PMID: 26842712
21. we summarize nesfatin-1 main functions, focusing on its cardiovascular implications--{REVIEW} PMID: 26662184
22. NUCB2 protein levels in the obese PCOS group were significantly lower than those in the non-obese PCOS and control groups. There was no statistically significant difference in the distribution of NUCB2 genotypes among the groups. PMID: 26369257
23. Nesfatin-1 hormone levels increased significantly in morbidly obese patients following laparoscopic sleeve gastrectomy. PMID: 27049252
24. serum level elevated in fetal growth retardation PMID: 26043295
25. Data indicate a positive correlation of nesfatin-1 and a negative correlation of orexin-A with body mass index. PMID: 26831553
26. 1012C>G polymorphism of NUCB2 is correlated with a reduced risk of developing MetS in a Chinese Han population. PMID: 26624852
27. In acute myocardial infarction patients, plasma nesfatin-1 levels were negatively correlated with high-sensitivity C-reactive protein, neutrophil% or Gensini scores. PMID: 23806888
28. nesfatin-1 might have an important role in regulation of food intake and pathogenesis of loss of appetite in children. PMID: 26744860
29. Nesfatin-1 levels were significantly lower in metabolic syndrome (MS) group compared to non-MS group PMID: 25432328
30. These results corroborate the suggestion of NUCB2/nesfatin-1 being relevantly involved in the regulation of mood and stress in a sex-specific way PMID: 26143537
31. Serum nesfatin-1 levels are significantly higher in girls with premature thelarche compared to prepubertal controls. PMID: 25833360
32. Circulating NUCB2/nesfatin-1 levels correlated positively with perceived anxiety, whereas no association with body mass index or eating disorder symptoms was observed. PMID: 26162003
33. Our results show that NUCB2 plays an important role in tumorigenesis and progression and is a potential molecular biomarker for the diagnosis and targeted therapy of ccRCC. PMID: 25322808
34. This investigation indicates a marked association of serum and synovial fluid nesfatin-1 concentrations with osteoarthritis disease severity. PMID: 25872767
35. This study shows an association of serum nesfatin-1 concentrations and the development and severity of peripheral arterial disease in type 2 diabetes mellitus patients. PMID: 25841171
36. Plasma IL-6 and TNF-alpha did not significantly change after training, but nesfatin increased significantly only with high-intensity interval training compared with the control group. PMID: 25581765
37. nesfatin-1 inhibits the growth of adrenocortical H295R cells and promotes apoptosis, potentially via the involvement of Bax, BCL-XL and BCL-2 genes as well as ERK1/2, p38 and JNK1/2 signalling cascades PMID: 25869615
38. Data suggest that plasma nesfatin-1/NUCB2 levels are up-regulated in pregnant women recently diagnosed with polycystic ovary syndrome (PCOS) as compared to healthy women; many of those with PCOS were also overweight and exhibited insulin resistance. PMID: 24920281
39. Data indicate that patients with severe preeclampsia showed significantly decreased levels of serum nesfatin-1 compared with those with mild preeclampsia. PMID: 24857385
40. there was no significant increase in postprandial level of nesfatin-1. This suggests that oral glucose load in obese children may not be sufficient for nesfatin-1 response and that nesfatin-1 may not have an effect as short-term regulator of food intake. PMID: 24825087
41. NUCB2/nesfatin-1 and visfatin are novel factors associated with systemic inflammation in COPD; visfatin may mediate impaired pulmonary diffusing capacity PMID: 24891763
42. Serum nesfatin-1 levels were measured in patients with subclinical or overt hyperthyroidism to see whether nesfatin-1 is involved in the regulation of appetite and body weight in hyperthyroidism. No significant difference from normal controls was found. PMID: 25068306
43. Increased nucleobindin-2 (NUCB2) transcriptional activity links the regulation of insulin sensitivity in Type 2 diabetes mellitus. PMID: 23765387
44. Nesfatin-1 might have an important role in regulation of food intake and pathogenesis of insulin resistance in obese children and young adolescents. PMID: 24333832
45. NUCB2 protein expression showed a strong association with the potencies of BCR and progression of PCa, and that may be applied as a novel biomarker. PMID: 24422979
46. Role of NUCB2/Nesfatin-1 in the hypothalamic control of energy homeostasis. PMID: 24048879
47. In advanced cystic fibrosis and low fat mass, nesfatin-1 plasma levels are significantly increased and inversely correlated with the fat mass. PMID: 23306670
48. plasma NUCB2/nesfatin-1 levels were altered under conditions of perceived anxiety, stress and depression in obese women. PMID: 23796625
49. Nesfatin-1 is present in articular tissues and may contribute to the physiopathologic changes in OA. Nesfatin-1, accompanied with hsCRP and IL-18, could have roles in the progression of knee osteoarthritis PMID: 24259949
50. we demonstrated that high NUCB2 mRNA expression correlated with poor overall survival in patients with prostate cancer PMID: 24092574

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HGNC: 8044

OMIM: 608020

KEGG: hsa:4925

STRING: 9606.ENSP00000436455

UniGene: Hs.654599