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  4. Recombinant Human Neuronal pentraxin-2 (NPTX2)

Recombinant Human Neuronal pentraxin-2 (NPTX2)

  • 中文名称：
    人NPTX2重组蛋白
  • 货号：
    CSB-YP016030HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NPTX2重组蛋白
  • 货号：
    CSB-EP016030HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NPTX2重组蛋白
  • 货号：
    CSB-EP016030HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NPTX2重组蛋白
  • 货号：
    CSB-BP016030HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NPTX2重组蛋白
  • 货号：
    CSB-MP016030HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NPTX2
  • Uniprot No.：
  • 别名：
    apexin; NARP; neuronal activity-regulated pentaxin; Neuronal pentraxin 2; Neuronal pentraxin II; Neuronal pentraxin-2; NP 2; NP-II; NP2; NPII ; NPTX2; NPTX2_HUMAN; pentraxin II, neuronal
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    16-431
  • 氨基酸序列
    GAQDS PAPGSRFVCT ALPPEAVHAG CPLPAMPMQG GAQSPEEELR AAVLQLRETV VQQKETLGAQ REAIRELTGK LARCEGLAGG KARGAGATGK DTMGDLPRDP GHVVEQLSRS LQTLKDRLES LEHQLRANVS NAGLPGDFRE VLQQRLGELE RQLLRKVAEL EDEKSLLHNE TSAHRQKTES TLNALLQRVT ELERGNSAFK SPDAFKVSLP LRTNYLYGKI KKTLPELYAF TICLWLRSSA SPGIGTPFSY AVPGQANEIV LIEWGNNPIE LLINDKVAQL PLFVSDGKWH HICVTWTTRD GMWEAFQDGE KLGTGENLAP WHPIKPGGVL ILGQEQDTVG GRFDATQAFV GELSQFNIWD RVLRAQEIVN IANCSTNMPG NIIPWVDNNV DVFGGASKWP VETCEERLLD L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner.
  • 基因功能参考文献：
    1. Neuronal pentraxin 2 predicts medial temporal atrophy and memory decline across the Alzheimer's disease spectrum. This research may advance the current understanding of Alzheimer's disease etiopathogenesis, while expanding early diagnostic techniques through the use of novel pro-inflammatory biomarkers, such as NPTX2. PMID: 27444967
    2. NPTX2 in human cerebrospinal fluid is reduced in subjects with Alzheimer's disease and shows robust correlations with cognitive performance and hippocampal volume. PMID: 28440221
    3. Decreased NPTX2 expression in rectal adenocarcinomas is associated with improved response to neoadjuvant chemoradiation and improved prognosis. PMID: 27083956
    4. we show that NPTX2 is a marker of poor prognosis for neuroblastoma patients. PMID: 26294210
    5. NPTX2 is overexpressed specifically in ccRCC primary tumors. PMID: 24962026
    6. NPTX2 repressed NF-kappaB activity by inhibiting AKT through a p53-PTEN-dependent pathway, thus explaining the hypermethylation and downregulation of NPTX2 in NF-kappaB-activated high-risk glioblastomas. PMID: 24078801
    7. Promoter methylation of NPTX2 is associated with glioblastoma. PMID: 23624749
    8. Detection of aberrant methylation of NPTX2 in pure pancreatic juice samples could be useful as a molecular marker to discriminate between patients with malignant and benign disease of the pancreas PMID: 23360791
    9. The visual cortex of NARP-deficient transgenic mice is hyperexcitable and unable to express ocular dominance, although many aspects of visual function are unimpaired. PMID: 23889936
    10. This study showed that the NPTX2 protein is down-regulated in human primary pancreatic cancers and in pancreatic cancer cell lines. PMID: 22806544
    11. This study demonistrated that childhood-onset mood disorders and suicide attempt association between HOMER1 rs2290639 and between NPTX2 markers rs705315 and rs1681248. PMID: 22460132
    12. Demonstrate for the first time that NARP mutation significantly enhances apoptotic death as a result of three distinct lethal mitochondrial apoptotic insults including oxidative, Ca(2+), and lipid stress. PMID: 21812817
    13. Data indicate that the aberrantly methylated NPTX2 gene may help to distinguish between chronic pancreatitis and pancreatic cancer with conventional diagnostic tools and could become a valuable diagnostic marker. PMID: 21778928
    14. NPTX2, as a tumor-suppressor, plays an anti-tumor effect on pancreatic cancer and its low expression, due to promoter hypermethylation, may play a role in the tumorigenesis of pancreatic cancer. PMID: 21161403
    15. study tested for the association of four SNPs of NPTX2 & haplotypes consisting of the SNPs with autism, between autistic patients & controls in a Japanese population; no significant difference was observed in allele, genotype or haplotype frequencies PMID: 17408830
    16. pancreatic cancer cytology samples had statistically significant higher levels of NPTX2 methylation compared with benign diseases PMID: 17895837
    17. Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies. PMID: 17987278
    18. Homoplasmic cybrids harboring the 8993T-->G NARP mutation were also protected from death (75% vs 15% survival at 72 hours) by the supplemented medium and their ATP content was similar to controls PMID: 19667215

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis.
  • 数据库链接：

    HGNC: 7953

    OMIM: 600750

    KEGG: hsa:4885

    STRING: 9606.ENSP00000265634

    UniGene: Hs.3281