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  4. Recombinant Human Neuron-specific calcium-binding protein hippocalcin (HPCA)

Recombinant Human Neuron-specific calcium-binding protein hippocalcin (HPCA)

  • 中文名称：
    人HPCA重组蛋白
  • 货号：
    CSB-YP010694HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HPCA重组蛋白
  • 货号：
    CSB-EP010694HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HPCA重组蛋白
  • 货号：
    CSB-BP010694HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HPCA重组蛋白
  • 货号：
    CSB-MP010694HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HPCA
  • Uniprot No.：
  • 别名：
    BDR 2; BDR2; Calcium binding protein BDR 2; Calcium binding protein BDR2; Calcium-binding protein BDR-2; HPCA; HPCA_HUMAN; Neuron specific calcium binding protein hippocalcin; Neuron-specific calcium-binding protein hippocalcin; P23K
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-193
  • 氨基酸序列
    GKQNSKLRP EMLQDLRENT EFSELELQEW YKGFLKDCPT GILNVDEFKK IYANFFPYGD ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGRLEQK LMWAFSMYDL DGNGYISREE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA SQF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases.
  • 基因功能参考文献：
    1. Sequence analysis of the HPCA gene in 505 patients with dystonia did not reveal variants in the coding regions of HPCA. PMID: 27145302
    2. hippocalcin forms oligomers upon calcium binding and directly interacts with VGCCs. The dystonia-causing mutations did not affect protein stability or folding. In common for both T71N and A190T mutants was an impaired calcium-dependent oligomerisation and increased intracellular calcium influx after KCl depolarisation. PMID: 28398555
    3. None of the patients enrolled was found to carry HPCA mutations, rising suspicion that these probably represent a very rare cause of dystonia in childhood-adolescence. PMID: 27771228
    4. Mutations in HPCA cause autosomal-recessive primary isolated dystonia. PMID: 25799108
    5. analysis of a novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents PMID: 22544757
    6. Hippocalcin is a sensitive Ca2+ sensor capable of responding to increases in intracellular Ca2+ concentration over the narrow dynamic range of 200-800 nM free Ca2+. PMID: 14638856
    7. The structural factors affecting the binding of hippocalcin to phosphatidylinositol 4,5-bisphosphate at the cell surface and the Golgi apparatus are described. PMID: 16053445
    8. Hippocalcin and MLK2 were colocalized in the halo of Lewy bodies in Parkinson disease patients, and neither protein was detected in normal pigmented neurons. PMID: 19332348
    9. diminished hippocalcin expression does not contribute to Huntington disease-related neurodegeneration PMID: 19686238

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  • 相关疾病：
    Dystonia 2, torsion, autosomal recessive (DYT2)
  • 亚细胞定位：
    Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    Recoverin family
  • 组织特异性：
    Brain specific.
  • 数据库链接：

    HGNC: 5144

    OMIM: 142622

    KEGG: hsa:3208

    STRING: 9606.ENSP00000362566

    UniGene: Hs.632391