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  4. Recombinant Human NF-kappa-B inhibitor zeta (NFKBIZ)

Recombinant Human NF-kappa-B inhibitor zeta (NFKBIZ)

  • 中文名称：
    人NFKBIZ重组蛋白
  • 货号：
    CSB-YP880137HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NFKBIZ重组蛋白
  • 货号：
    CSB-EP880137HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NFKBIZ重组蛋白
  • 货号：
    CSB-EP880137HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NFKBIZ重组蛋白
  • 货号：
    CSB-BP880137HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NFKBIZ重组蛋白
  • 货号：
    CSB-MP880137HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NFKBIZ
  • Uniprot No.：
  • 别名：
    FLJ30225; FLJ34463; I-kappa-B-zeta; Ikappa B zeta; IkappaB zeta; IkappaBzeta; IkB-zeta; IKBZ; IKBZ_HUMAN; IKBzeta; IL-1 inducible nuclear ankyrin-repeat protein; INAP; MAIL; MAIL protein; Molecule possessing ankyrin repeats induced by lipopolysaccharide; NF-kappa-B inhibitor zeta; NFKBIZ; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor zeta
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-718
  • 氨基酸序列
    MIVDKLLDDS RGGEGLRDAA GGCGLMTSPL NLSYFYGASP PAAAPGACDA SCSVLGPSAP GSPGSDSSDF SSASSVSSCG AVESRSRGGA RAERQPVEPH MGVGRQQRGP FQGVRVKNSV KELLLHIRSH KQKASGQAVD DFKTQGVNIE QFRELKNTVS YSGKRKGPDS LSDGPACKRP ALLHSQFLTP PQTPTPGESM EDVHLNEPKQ ESSADLLQNI INIKNECSPV SLNTVQVSWL NPVVVPQSSP AEQCQDFHGG QVFSPPQKCQ PFQVRGSQQM IDQASLYQYS PQNQHVEQQP HYTHKPTLEY SPFPIPPQSP AYEPNLFDGP ESQFCPNQSL VSLLGDQRES ENIANPMQTS SSVQQQNDAH LHSFSMMPSS ACEAMVGHEM ASDSSNTSLP FSNMGNPMNT TQLGKSLFQW QVEQEESKLA NISQDQFLSK DADGDTFLHI AVAQGRRALS YVLARKMNAL HMLDIKEHNG QSAFQVAVAA NQHLIVQDLV NIGAQVNTTD CWGRTPLHVC AEKGHSQVLQ AIQKGAVGSN QFVDLEATNY DGLTPLHCAV IAHNAVVHEL QRNQQPHSPE VQELLLKNKS LVDTIKCLIQ MGAAVEAKDR KSGRTALHLA AEEANLELIR LFLELPSCLS FVNAKAYNGN TALHVAASLQ YRLTQLDAVR LLMRKGADPS TRNLENEQPV HLVPDGPVGE QIRRILKGKS IQQRAPPY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR).
  • 基因功能参考文献：
    1. electrophilic properties of itaconate and derivatives regulate the IkappaBzeta-ATF3 inflammatory axis; results demonstrate that targeting the DI-IkappaBzeta regulatory axis could be an important new strategy for the treatment of IL-17-IkappaBzeta-mediated autoimmune diseases PMID: 29670287
    2. we demonstrate that IkappaBzeta, a transcriptional co-activator, may play an important role in psoriasis and possibly other inflammatory diseases by mediating IL-17F- driven effects. PMID: 27576147
    3. this study shows association of common intragenic NFKBIZ polymorphisms with the risk of developing psoriasis PMID: 28259733
    4. a specific IL-17A-induced gene, NFKBIZ, which encodes IkappaB-zeta, a transcriptional regulator for NF-kappaB, was demonstrated to have a significant role for IL-17A-induced gene expression. PMID: 26944069
    5. In cultured macrophages, LPS-induced expression of monocyte chemoattractant protein (MCP)-1 was suppressed by NaN3 through inhibition of STAT1 and IkappaBzeta activities. PMID: 28391993
    6. IkappaB-zeta regulates human monocyte pro-inflammatory responses induced by Streptococcus pneumoniae. PMID: 27597997
    7. TNF-alpha- and IL-17A mediate synergistic induction of DEFB4 gene expression in human keratinocytes through IkappaBzeta PMID: 27117051
    8. We propose a previously unappreciated role of IkappaBzeta in the inflammatory micromilieu as well as progression in glioma PMID: 26398661
    9. These results indicate that the LPS/IL-1beta-MyD88 axis plays a crucial role for stabilization of IkappaB-zeta mRNA. PMID: 26711529
    10. Interferon-gamma (IFN-gamma) interferes with the IL-1/IKB-zeta axis in beta-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFN-gamma and IL-22. PMID: 25474109
    11. NFKBIZ gene knockdown in bronchial epithelial cells suppresses the release of IL-1b-induced IL-6 and GMCSF. PMID: 25629767
    12. IkappaBzeta functions as an important regulator of IFN-gamma in human NK cells PMID: 21224476
    13. NF-kappaB-binding cofactor inhibitor of NF-kappaB-zeta (IkappaB-zeta) is constitutively expressed in HTLV-I-infected T cell lines and ATL cells, and Tax transactivates the IkappaB-zeta gene, mainly through NF-kappaB. PMID: 24027435
    14. our data demonstrate that IkappaB-zeta is essential for nuclear NF-kappaB activity in activated B-cell-like subtype of diffuse large B-cell lymphoma PMID: 23869088
    15. investigation of signaling components that induce activation of post-transcriptional mechanism for IkappaB-zeta induction/activation: Activation of IRAK1 or IRAK4, but not TRAF6, is sufficient. PMID: 22059479
    16. analysis of the sequence of flagellin/TLR5- and type IV-dependent IkappaBzeta expression, recruitment of IkappaBzeta/p50 to the il6 promoter, chromatin remodelling and subsequent IL-6 transcription in L. pneumophila-infected lung epithelial cells PMID: 20650996
    17. conclude that multiple NFKBIZ polymorphisms associate with susceptibility to IPD in humans. The study of multiple populations may aid in fine mapping of associations within extensive regions of strong linkage disequilibrium PMID: 19798075
    18. silencing of IkappaBzeta expression led to a specific decrease in IFNgamma production. Overall, our data suggests that IkappaBzeta positively regulates NFkappaB-mediated IFNgamma production in KG-1 cells PMID: 19707556
    19. These results indicate the existence of another signal essential for I kappa B-zeta induction, which is specifically mediated by the Toll/interleukin-1 receptor (TIR) domain-mediated signaling pathway. PMID: 12565889
    20. IkappaB-zeta harbors latent transcriptional activation activity which is expressed upon interaction with the NF-kappaB p50 subunit PMID: 15618216
    21. IkappaB-zeta functions as an additional regulator of NF-kappaB activity PMID: 16513645
    22. IL-1beta specificity is caused by a requirement of the neutrophil gelatinase-associated lipocalin promoter for the NF-kappaB-binding cofactor IkappaB-zeta for transcriptional activation PMID: 16622025
    23. IkappaB-zeta acts as an essential transcriptional activator by forming a complex with NF-kappaB on promoters harbouring the NF-kappaB- and C/EBP-binding sites. PMID: 17447895
    24. the NF-kappaB binding cofactor, IkappaB-zeta, was up-regulated by IL-17A, and the knockdown of IkappaB-zeta significantly diminished the IL-17A-induced hBD-2 expression. PMID: 18362142
    25. I kappaB zeta binds preferentially to NF-kappaB p50 homodimers. PMID: 18436238
    26. The nuclear factor NFKBIZ colocalizes with FUS-DDIT3 in nuclear structures. FUS-DDIT3 binds the C-terminal of NFKBIZ. FUS-DDIT3 deregulates some NF-kappaB-controlled genes through interactions with NFKBIZ. PMID: 18850010
    27. These results suggest that IkappaB-zeta is a negative regulator of STAT3, and demonstrate a novel mechanism in which a component of the NF-kappaB signaling pathway inhibits the activation of STAT3. PMID: 19595668
    28. MAIL is a key regulator of IL-6 production in human monocytes and plays an important role in both TLR and NOD-like receptor ligand induced inflammation. PMID: 19783680

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  • 亚细胞定位：
    Nucleus. Note=Aggregated in dot-like structures. Colocalizes with NCOR2.
  • 组织特异性：
    Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart.
  • 数据库链接：

    HGNC: 29805

    OMIM: 608004

    KEGG: hsa:64332

    STRING: 9606.ENSP00000325663

    UniGene: Hs.319171