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  4. Recombinant Human N-terminal EF-hand calcium-binding protein 2 (NECAB2)

Recombinant Human N-terminal EF-hand calcium-binding protein 2 (NECAB2)

  • 中文名称：
    人NECAB2重组蛋白
  • 货号：
    CSB-YP800222HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NECAB2重组蛋白
  • 货号：
    CSB-EP800222HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NECAB2重组蛋白
  • 货号：
    CSB-EP800222HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NECAB2重组蛋白
  • 货号：
    CSB-BP800222HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NECAB2重组蛋白
  • 货号：
    CSB-MP800222HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NECAB2
  • Uniprot No.：
  • 别名：
    EF hand calcium binding protein 2; EF-hand calcium-binding protein 2; N-terminal EF-hand calcium-binding protein 2; NECA2_HUMAN; Necab2; Neuronal calcium binding protein 2; Neuronal calcium-binding protein 2; Stip 2 ; Stip-2; Stip2 ; Synaptotagmin interacting protein 2; Synaptotagmin-interacting protein 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-386
  • 氨基酸序列
    MCERAARLCR AGAHRLLREP PQQGRALGGL LRWVGARMGE PRESLAPAAP ADPGPASPRG GTAVILDIFR RADKNDDGKL SLEEFQLFFA DGVLNEKELE DLFHTIDSDN TNHVDTKELC DYFVDHMGDY EDVLASLETL NHSVLKAMGY TKKVYEGGSN VDQFVTRFLL KETANQIQSL LSSVESAVEA IEEQTSQLRQ NHIKPSHSAA QTWCGSPTPA SAPNHKLMAM EQGKTLPSAT EDAKEEGLEA QISRLAELIG RLESKALWFD LQQRLSDEDG TNMHLQLVRQ EMAVCPEQLS EFLDSLRQYL RGTTGVRNCF HITAVRLSDG FTFVIYEFWE TEEAWKRHLQ SPLCKAFRHV KVDTLSQPEA LSRILVPAAW CTVGRD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.
  • 基因功能参考文献：
    1. Study suggests that the phenotypic segregation of Neuronal calcium-binding protein 1 and -2 (NECAB1 and -2) to respective excitatory and inhibitory spinal systems can underpin functional modalities in determining the fidelity of synaptic neurotransmission and neuronal responsiveness, and might bear translational relevance to humans. PMID: 26843217
    2. NECAB2 by its physical interaction with mGlu(5b) receptor modulates receptor function PMID: 19694902
    3. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18519826
  • 亚细胞定位：
    Cytoplasm. Cell projection, dendrite. Cell projection, axon. Cell membrane.
  • 组织特异性：
    Expressed in brain. Expressed in the spinal dorsal horn with especially strong expression in lamina IIi; found in excitory synaptic boutons and in ependymal cells (at protein level).
  • 数据库链接：

    HGNC: 23746

    KEGG: hsa:54550

    UniGene: Hs.140950