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  4. Recombinant Human Low molecular weight phosphotyrosine protein phosphatase (ACP1)

Recombinant Human Low molecular weight phosphotyrosine protein phosphatase (ACP1)

  • 中文名称：
    Recombinant Human Low molecular weight phosphotyrosine protein phosphatase(ACP1),Yeast
  • 货号：
    CSB-YP001176HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Low molecular weight phosphotyrosine protein phosphatase(ACP1),Yeast
  • 货号：
    CSB-EP001176HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Low molecular weight phosphotyrosine protein phosphatase(ACP1),Yeast
  • 货号：
    CSB-BP001176HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Low molecular weight phosphotyrosine protein phosphatase(ACP1),Yeast
  • 货号：
    CSB-MP001176HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ACP1
  • Uniprot No.：
  • 别名：
    Acid phosphatase 1 soluble; Acid phosphatase of erythrocyte ; ACP1; Adipocyte acid phosphatase; Cytoplasmic phosphotyrosyl protein phosphatase; HAAP; LMW-PTP; LMW-PTPase; Low molecular weight cytosolic acid phosphatase; Low molecular weight phosphotyrosine protein phosphatase; PAP1; PAP2; phosphatase; acid; of erythrocyte; PPAC_HUMAN; Protein tyrosine phosphatase; PTPase; Purple acid phosphatase; Red cell acid phosphatase 1; testicular secretory protein Li 37
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length of Isoform 1
  • 表达区域：
    1-158
  • 氨基酸序列
    MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
  • 基因功能参考文献：
    1. ACP1 may have an important role in regulation of the multiple systems associated with suicide. PMID: 28668716
    2. Conditioned medium from MDA-MB-231 breast cancer cells with total knockdown of LMW-PTP, but not of slow isoform LMW-PTP, significantly reduced osteoclast differentiation of RAW 264.7 cells. PMID: 29187443
    3. results confirm the role of TPH1, TPH2, 5HT2A, CRHR1 and ACP1 variants in the risk of suicidal behavior. PMID: 27479537
    4. These data support that PTPN22 1858C/T, PTPRJ 2965C/G and 1176 A/C polymorphisms and ACP1 A, B and C alleles are not associated with a higher risk of immune thrombocytopenia P in adults. PMID: 27309885
    5. The LMW-PTP slow isoform can be an important protein in bone metastatic disease, with a fundamental role in the interplay between tumor cells and osteoclasts, through the regulation of Src activity and IL-8 secretion. PMID: 27127127
    6. Overexpression of LMWPTP in prostate cancer confers a malignant phenotype with worse clinical outcome. PMID: 26159288
    7. ADA6, PTPN22 and ACP1 are involved in immune reactions: since endometriosis has an autoimmune component. PMID: 26216523
    8. LMPTP expression increases in end-stage heart failure in humans PMID: 26213100
    9. Suggest that hypermethylation of ACP1, BMP4, and TSPYL5 are common events in HCC and could be used as potentially detectable biomarkers in HCC tissues. PMID: 26386860
    10. the present study found that the ACP1*C allele, previously associated with an increased vulnerability to infectious/parasitic diseases may also be able to shape behavioral immune defenses by interaction with the level of E. PMID: 24933463
    11. Association of an increased risk of coronary artery disease, especially in females, with ACP1 polymorphisms. PMID: 25846885
    12. ACP1 knockdown attenuates effects of osmotic stress in HaCaT cells, mainly in the status of Src kinase, Rac and STAT5 phosphorylation and activity. PMID: 25781955
    13. The rs3828329 of ACP1 gene is also a risk factor of CAD in Han Chinese females aged 65 years and older. PMID: 25123136
    14. ACP1 polymorphism is associated with type 1 diabetes mellitus. PMID: 25125338
    15. In ACP1 *B/*C genotype, which shows the highest enzymatic activity, spermatic concentration is significantly lower and atypical spermatozoa are significantly more frequent as compared to other ACP1 genotypes. PMID: 23278455
    16. In Class 3 people the combination of high ACP f-isozyme concentration and the ADA*2 allele, lowers the rate of glycolysis that may reduce the amount of metabolic calories and activates Sirtuin genes that protect cells against age-related diseases. PMID: 23959645
    17. certain genotypes of ACP1 associated with high phosphatase activity may increase the T-cell response to PF4-heparin complexes, with higher levels of circulating antibodies PMID: 23621699
    18. A significant increase of PTPN22 *T allele in endometriosis is observed in women carrying ACP1*C allele, in women carrying p53 codon 72 *Pro allele PMID: 23453606
    19. clarification of the importance of ACP1 in carcinogenesis through the analysis of LMW-PTP interaction with different substrates [review] PMID: 23584899
    20. The data suggest an interaction between p53 codon 72 and ACP wherein a positive effect of the p53 *Pro allele on susceptibility to coronary artery disease occurs. PMID: 23197232
    21. mRNA expression of the slow isoform was increased in breast cancer and that of the fast isoform was reduced in breast cancer. PMID: 23645747
    22. balanced redox-state is required for VEGF to facilitate reversible S-glutathionylation of LMW-PTP, FAK activation and endothelial cell migration PMID: 22854047
    23. lack of association with inflammatory bowel disease in Spanish patients PMID: 22428720
    24. There is a significant association between acid phosphatase locus 1 (ACP(1) and cancer grade, mainly due to ACP(1) genotypes carrying the *C allele that are much less represented in patients with low grade when compared with those with high grade. PMID: 22692348
    25. the ACP1 protein is a tyrosine phosphatase that influences Wnt signaling, a pathway regulated by lithium, making ACP1 a functional candidate for involvement in the phenotype. PMID: 21423239
    26. Data indicate that ACP1 rs11553742*T with increased susceptibility in systemic lupus erythematosus (SLE) patients. PMID: 22064183
    27. Gain of the telomeric region 2p25.3 harboring the ACP1 gene is common in CLL (25%, 44 of 178 cases). PMID: 22035742
    28. the ACP1*C allele influences the risk of cardiovascular disease events in patients with rheumatoid arthritis. PMID: 21767392
    29. Although both variants dephosphorylate the EPHA2 receptor, the rate and specificity of dephosphorylation for specific tyrosines are different for ACP1 and human cytoplasmic protein tyrosine phosphatase-B. PMID: 21538645
    30. investigated hypothesis that favism is caused by toxic Vicia faba substances, which in some ACP1 phenotypes cause increased phosphorylation and thus increased glycolysis, with strong reduction in reduced glutathione production, resulting in hemolysis PMID: 21644204
    31. In overweight women (BMI > 25), the proportion of low activity ACP1 phenotypes is much lower in type 1 diabetes than in gestational diabetes and in healthy females. PMID: 19855922
    32. the correlation between blood glucose and glycated Hb in relation to AK1 and ACP1 polymorphism was studied. PMID: 20152999
    33. Type 1 diabetes subjects show a highly significant increase of ACP1*A/ADA1*2 gametic type compared with healthy subjects from the same population (P = 0.003). PMID: 20805743
    34. association with coronary artery disease evident only in diabetic subjects and dependent on female gender PMID: 20581655
    35. A significant interaction between ACP1 and ADA1 concerning susceptibility to type 1 diabetes, was revealed. PMID: 19789510
    36. ACP1 is associated with allergy PMID: 12100313
    37. Association of the ACP1 genotype with metabolic parameters upon initial diagnosis of type 1 diabetes. PMID: 12640337
    38. LMW-PTP has a role in immunological synapse establishment and stabilization through the negative control of FAK activity and of cell surface receptor redistribution PMID: 12815062
    39. The analysis involved the data on nine polymorphic codominant loci: HP, GC, TF, PI, PGM1, GLO1, C3, ACP1, and ESD. The loci were selected by significance of differences in genotype frequencies between tuberculosis patients and healthy controls PMID: 12942785
    40. We show that the association of STAT5 and LMW-PTP does not exclusively involve the phosphatase active site and phosphotyrosine residue of STAT5. PMID: 14637146
    41. acid phosphatase 1 contributes to the clinical manifestations of type 2 diabetes and probably also have a marginal influence on susceptibility to the disease PMID: 15281007
    42. complex interaction among maternal age, sex of infant and ACP1 concerning age at diagnosis of diabetes PMID: 15586390
    43. Finds ACP1*C is a recessively deleterious allele that reduces viability during early life stages and is not maintained by overdominant selection in European populations. PMID: 15974295
    44. Significant correlations between LMW-PTP overexpression and the most common clinical-pathological features of cancers exist. In colon cancer and neuroblastoma increased total LMW-PTP mRNA expression correlates with unfavourable outcome. PMID: 16036221
    45. Crystal structure of the second human low molecular weight PTPase isoenzyme provides the opportunity to examine the structural basis of different substrate and inhibitor/activator responses. PMID: 16253994
    46. mother/newborn pairs: ACP1 (acid phosphatase 1)distribution has fewer pairs with maternal low ACP1 S isoform and infant high S isoform concentration;Recurrent spontaneous abortion couples show wife low S isoform and husband high S isoform concentration PMID: 16762482
    47. GRX plays an important role in PDGF-BB-dependent cell proliferation by regulating the redox state of LMW-PTP PMID: 16893901
    48. Among newborns carrying the ACP1C allele there is an increase of Sex Ratio among the offspring of smoking mothers relative to non-smoking mothers. PMID: 16973312
    49. Human recombinant LMWPTP-A displayed an RN5Pase activity that was higher than its tyrosine phosphatase activity, indicating that this phosphatase may participate in protein deglycation, a new form of protein repair. PMID: 17472574
    50. results suggest a cooperative effect of ADA and ACP1 genetic polymorphism on the susceptibility to repeated spontaneous abortion and to some of its clinical characteristics PMID: 17565542

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Low molecular weight phosphotyrosine protein phosphatase family
  • 组织特异性：
    T-lymphocytes express only isoform 2.
  • 数据库链接：

    HGNC: 122

    OMIM: 171500

    KEGG: hsa:52

    STRING: 9606.ENSP00000272065

    UniGene: Hs.558296