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  4. Recombinant Human Low affinity cationic amino acid transporter 2 (SLC7A2), partial

Recombinant Human Low affinity cationic amino acid transporter 2 (SLC7A2), partial

  • 中文名称：
    人SLC7A2重组蛋白
  • 货号：
    CSB-YP021714HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SLC7A2重组蛋白
  • 货号：
    CSB-EP021714HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SLC7A2重组蛋白
  • 货号：
    CSB-EP021714HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SLC7A2重组蛋白
  • 货号：
    CSB-BP021714HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SLC7A2重组蛋白
  • 货号：
    CSB-MP021714HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC7A2
  • Uniprot No.：
  • 别名：
    ATRC2; 20.5; Amino acid transporter; cationic 2 (low affinity); ATRC 2; CAT 2; CAT-2; CAT2; Cat2a; Cat2b; Cationic amino acid transporter 2A; cationic amino acid transporter; y+ system; low affinity cationic amino acid transporter 2; CTR2_HUMAN; HCAT 2; HCAT2; Low affinity cationic amino acid transporter 2; OTTHUMP00000216432; OTTHUMP00000216433; OTTMUSP00000041667; OTTMUSP00000041669; RCAT2; SLC7A 2; Slc7a2; Solute carrier family 7 member 2; T cell early activation protein; Tea
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). May play a role in classical or alternative activation of macrophages via its role in arginine transport.
  • 基因功能参考文献：
    1. genetic association studies in population in Tennessee: Data suggest that an SNP in SLC7A2 (rs2720574) is associated with response to dietary calcium and magnesium in prevention of colorectal polyps and colorectal ademonas. PMID: 28501704
    2. Identification of cysteine residues in human cationic amino acid transporter hCAT-2A that are targets for inhibition by N-ethylmaleimide. PMID: 24019517
    3. A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport. PMID: 22787143
    4. Addition of spermine or knockdown of CAT2 inhibited L-Arg uptake, NO production, and iNOS protein levels, whereas knockdown of ODC had the opposite effect. CAT2 and ODC were increased in mouse and human H pylori gastritis tissues. PMID: 20600019
    5. Insulin increased L-arginine transport and the mRNA levels for hCAT-1 and hCAT-2B PMID: 15064952

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amino acid-polyamine-organocation (APC) superfamily, Cationic amino acid transporter (CAT) (TC 2.A.3.3) family
  • 组织特异性：
    Expressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate levels in the liver and pancreas and at low levels in the kidney and heart.
  • 数据库链接：

    HGNC: 11060

    OMIM: 601872

    KEGG: hsa:6542

    STRING: 9606.ENSP00000004531

    UniGene: Hs.448520