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  4. Recombinant Human LIM/homeobox protein Lhx4 (LHX4)

Recombinant Human LIM/homeobox protein Lhx4 (LHX4)

  • 中文名称：
    人LHX4重组蛋白
  • 货号：
    CSB-YP846571HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LHX4重组蛋白
  • 货号：
    CSB-EP846571HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LHX4重组蛋白
  • 货号：
    CSB-EP846571HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LHX4重组蛋白
  • 货号：
    CSB-BP846571HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LHX4重组蛋白
  • 货号：
    CSB-MP846571HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LHX4
  • Uniprot No.：
  • 别名：
    CPHD4; Gsh 4; Gsh4; Lhx4; LHX4_HUMAN; LIM Homeobox 4; LIM Homeobox gene 4; LIM homeobox protein 4; LIM/homeobox protein Lhx4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-390
  • 氨基酸序列
    MMQSATVPAE GAVKGLPEML GVPMQQIPQC AGCNQHILDK FILKVLDRHW HSSCLKCADC QMQLADRCFS RAGSVYCKED FFKRFGTKCT ACQQGIPPTQ VVRKAQDFVY HLHCFACIIC NRQLATGDEF YLMEDGRLVC KEDYETAKQN DDSEAGAKRP RTTITAKQLE TLKNAYKNSP KPARHVREQL SSETGLDMRV VQVWFQNRRA KEKRLKKDAG RHRWGQFYKS VKRSRGSSKQ EKESSAEDCG VSDSELSFRE DQILSELGHT NRIYGNVGDV TGGQLMNGSF SMDGTGQSYQ DLRDGSPYGI PQSPSSISSL PSHAPLLNGL DYTVDSNLGI IAHAGQGVSQ TLRAMAGGPT SDISTGSSVG YPDFPTSPGS WLDEMDHPPF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA.
  • 基因功能参考文献：
    1. LHX4 Mutation is associated with Pituitary Deficits. PMID: 27820671
    2. The study identified 4 new LHX4 heterozygous allelic variants in patients with congenital hypopituitarism: W204X, delK242, N271S and Q346R. PMID: 25955177
    3. A novel homozygous mutation in LHX4 associated with a lethal phenotype, implying that recessive mutations in LHX4 may be incompatible with life. PMID: 25871839
    4. we found that LHX4 upregulated beta-catenin levels in human colorectal cancer cell lines PMID: 25034524
    5. Data indicate that HESX1, LHX4 and SOX3 polymorphisms may be associated with pituitary stalk interruption syndrome (PSIS). PMID: 23199197
    6. This study is the first to describe, a gradual loss of ACTH in a patient carrying an LHX4 mutation. PMID: 23029363
    7. Variably penetrant pituitary insufficiency, including this severe and atypical presentation, can be correlated with LHX4 insufficiency and highlights the role of LHX4 for pituitary development. PMID: 22232309
    8. data indicate that LHX4 may act as a potential tumor suppressor in hepatocarcinogenesis, suggesting that targeting LHX4 to downregulate AFP might have therapeutic implications PMID: 21965270
    9. A novel HESX1 causative mutation was found in a consanguineous family, and two LHX4 mutations were present in familial Pituitary stalk interruption syndrome. PMID: 21270112
    10. Heterozygous splice site mutations within LHX4 are associated with combined pituitary hormone deficiency and isolated growth hormone deficiency... small sella turcica...persistent craniopharyngeal canal...ectopic posterior pituitary... P. 207 PMID: 14714741
    11. LHX4 expression is transient, and, at 6 weeks of development, is stronger at the caudal than at the cervical level. PMID: 15567726
    12. Findings are consistent with the existence of LHX4-driven pathway leading to expression of GH through transcriptional activation of POU1F1. They argue against dominant-negative effect of mutant LHX4 proteins over normal LHX4. PMID: 15998782
    13. endogenous LHX4 binds to the CGA promoter and that LHX4-mediated CGA activation is enhanced by the SS18-SSX protein PMID: 17667940
    14. We conclude Sp1 directly regulates Lhx4 gene expression. PMID: 18053794
    15. LHX4 mutations are a relatively rare cause of combined pituitary hormone deficiency. PMID: 18073311
    16. three new exonic LHX4 allelic variants with at least one being responsible for congenital hypopituitarism. PMID: 18445675
    17. In mice, a similar protein plays a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. PMID: 7913017
    18. germline mutations; phenotype characterized by short stature and by pituitary, hindbrain, and skull abnormalities PMID: 11567216

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  • 相关疾病：
    Pituitary hormone deficiency, combined, 4 (CPHD4)
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 21734

    OMIM: 262700

    KEGG: hsa:89884

    STRING: 9606.ENSP00000263726

    UniGene: Hs.658487