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  4. Recombinant Human LIM/homeobox protein Lhx2 (LHX2)

Recombinant Human LIM/homeobox protein Lhx2 (LHX2)

  • 中文名称：
    人LHX2重组蛋白
  • 货号：
    CSB-YP012920HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LHX2重组蛋白
  • 货号：
    CSB-EP012920HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LHX2重组蛋白
  • 货号：
    CSB-EP012920HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LHX2重组蛋白
  • 货号：
    CSB-BP012920HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LHX2重组蛋白
  • 货号：
    CSB-MP012920HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LHX2
  • Uniprot No.：
  • 别名：
    hLhx2 ; Homeobox protein LH-2; Homeobox protein LH2; LH2; LHX2; LHX2_HUMAN; LIM homeobox 2; LIM homeobox protein 2; LIM HOX gene 2; LIM/homeobox protein Lhx2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-406
  • 氨基酸序列
    MLFHSLSGPE VHGVIDEMDR RAKSEAPAIS SAIDRGDTET TMPSISSDRA ALCAGCGGKI SDRYYLLAVD KQWHMRCLKC CECKLNLESE LTCFSKDGSI YCKEDYYRRF SVQRCARCHL GISASEMVMR ARDLVYHLNC FTCTTCNKML TTGDHFGMKD SLVYCRLHFE ALLQGEYPAH FNHADVAAAA AAAAAAKSAG LGAAGANPLG LPYYNGVGTV QKGRPRKRKS PGPGADLAAY NAALSCNEND AEHLDRDQPY PSSQKTKRMR TSFKHHQLRT MKSYFAINHN PDAKDLKQLA QKTGLTKRVL QVWFQNARAK FRRNLLRQEN TGVDKSTDAA LQTGTPSGPA SELSNASLSP SSTPTTLTDL TSPTLPTVTS VLTSVPGNLE GHEPHSPSQT TLTNLF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types.
  • 基因功能参考文献：
    1. These data indicate that Lhx2 is capable of blocking proliferation of T-ALL-derived cells by both LMO2-dependent and -independent means. We propose Lhx2 as a new molecular tool for anti-T-ALL drug development. PMID: 29278703
    2. Findings demonstrate that miR-1238 inhibit the proliferation of NSCLC cells at least partly via repression of LHX2, shedding light on the mechanistic interaction of miR-1238 and LHX2 in NSCLC carcinogenesis. PMID: 26189214
    3. Results show that LHX2 is overexpressed in pancreatic ductal adenocarcinoma cells and is involved in promoting cancer cell proliferation and enhanced tumor development. PMID: 25324171
    4. Lhx2 directly regulates tanycyte specification and differentiation in the hypothalamus. PMID: 25505333
    5. This study demonistrated that LHx2 regulates the development of the forebrain hem system. PMID: 23307637
    6. The data indicate a dual role of Lhx2 during EMT and tumor progression: by inducing the expression of PDGF-B, Lhx2 provokes an autocrine PDGF-B/PDGFRbeta loop required for cell migration, invasion and metastatic dissemination PMID: 24423492
    7. The findings indicate that LHX2 regulates the transcription of downstream intrinsic and extrinsic molecules that are essential for early neural differentiation. PMID: 23804753
    8. These results suggest that if LHX2 is involved in pituitary hormone deficiency associated with posterior pituitary and ocular defects, it would be a rare cause of this disease condition. PMID: 22535646
    9. Mutations in LHX2 do not represent a frequent cause of micro/anophthalmia. PMID: 21203406

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 6594

    OMIM: 603759

    KEGG: hsa:9355

    STRING: 9606.ENSP00000362717

    UniGene: Hs.696425