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  4. Recombinant Human Kinesin-like protein KIF3B (KIF3B)

Recombinant Human Kinesin-like protein KIF3B (KIF3B)

  • 中文名称：
    人KIF3B重组蛋白
  • 货号：
    CSB-YP012336HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人KIF3B重组蛋白
  • 货号：
    CSB-EP012336HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人KIF3B重组蛋白
  • 货号：
    CSB-EP012336HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人KIF3B重组蛋白
  • 货号：
    CSB-BP012336HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人KIF3B重组蛋白
  • 货号：
    CSB-MP012336HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KIF3B
  • Uniprot No.：
  • 别名：
    HH0048; KIAA0359; KIF3B; KIF3B_HUMAN; Kinesin family member 3B ; Kinesin like protein KIF3B ; Kinesin-like protein KIF3B; Microtubule plus end directed kinesin motor 3B; Microtubule plus end-directed kinesin motor 3B; Similar to Mouse kinesin KIF3B
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-747
  • 氨基酸序列
    MSKLKSSESV RVVVRCRPMN GKEKAASYDK VVDVDVKLGQ VSVKNPKGTA HEMPKTFTFD AVYDWNAKQF ELYDETFRPL VDSVLQGFNG TIFAYGQTGT GKTYTMEGIR GDPEKRGVIP NSFDHIFTHI SRSQNQQYLV RASYLEIYQE EIRDLLSKDQ TKRLELKERP DTGVYVKDLS SFVTKSVKEI EHVMNVGNQN RSVGATNMNE HSSRSHAIFV ITIECSEVGL DGENHIRVGK LNLVDLAGSE RQAKTGAQGE RLKEATKINL SLSALGNVIS ALVDGKSTHI PYRDSKLTRL LQDSLGGNAK TVMVANVGPA SYNVEETLTT LRYANRAKNI KNKPRVNEDP KDALLREFQE EIARLKAQLE KRSIGRRKRR EKRREGGGSG GGGEEEEEEG EEGEEEGDDK DDYWREQQEK LEIEKRAIVE DHSLVAEEKM RLLKEKEKKM EDLRREKDAA EMLGAKIKAM ESKLLVGGKN IVDHTNEQQK ILEQKRQEIA EQKRREREIQ QQMESRDEET LELKETYSSL QQEVDIKTKK LKKLFSKLQA VKAEIHDLQE EHIKERQELE QTQNELTREL KLKHLIIENF IPLEEKSKIM NRAFFDEEED HWKLHPITRL ENQQMMKRPV SAVGYKRPLS QHARMSMMIR PEARYRAENI VLLELDMPSR TTRDYEGPAI APKVQAALDA ALQDEDEIQV DASSFESTAN KKSKARPKSG RKSGSSSSSS GTPASQLYPQ SRGLVPK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule. Plays a role in cilia formation. Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors. Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites.
  • 基因功能参考文献：
    1. The rate of transport is set by an equilibrium between a faster state, where only kinesin family member 17 protein (KIF17) motors move the train, and a slower state, where at least one kinesin family member 3A/B protein (KIF3AB) motor on the train remains active in transport. PMID: 28761002
    2. High KIF3B expression is associated with seminoma. PMID: 28161539
    3. These data suggest that GLI interactions with KIF3A-KIF3B-KAP3 complexes are essential for proper GLI transcriptional activity. PMID: 25588831
    4. both motor domains of KIF3A/B coordinate for processive motility and move at different speeds PMID: 15345558
    5. Results suggest that KIF3B expression was upregulated in HCC tumor tissues and proliferating HCC cells, and an increasd KIF3B expression was associated with poor overall survival. PMID: 24368420
    6. KIF3B is involved in the trafficking of kAE1 to the plasma membrane of human kidney alpha-intercalated cells. PMID: 21871436
    7. Interaction with KIF3B alters CLC-5 cell surface expression, chloride current, and alters albumin endocytosis. Interaction with KIF3B facilitates microtubular transport and endocytosis of CLC-5-containing vesicles away from cell surface. PMID: 19940036
    8. Interaction of KIF3A/3B with KAP3 may be important for the proper progression of mitosis. PMID: 16298999
    9. kinesin-2 is a linker between polycystin-2(PC2) and fibrocystin and mediates the regulation of PC2 channel function by fibrocystin PMID: 17008358
    10. Rip11/FIP5-kinesin-II complex plays a key role in the routing of internalized receptors through the perinuclear recycling endosomes. PMID: 18957512
    11. Data indicate that p0071 and Ect2 are transported via distinct motors and identify a novel pathway implicating KIF3 in the regulation of actin organization during cytokinesis PMID: 19339549

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell projection, cilium. Cell projection, dendritic spine.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Kinesin II subfamily
  • 数据库链接：

    HGNC: 6320

    OMIM: 603754

    KEGG: hsa:9371

    STRING: 9606.ENSP00000364864

    UniGene: Hs.369670