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  4. Recombinant Human Interferon-induced GTP-binding protein Mx2 (MX2)

Recombinant Human Interferon-induced GTP-binding protein Mx2 (MX2)

  • 中文名称：
    人MX2重组蛋白
  • 货号：
    CSB-YP015250HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MX2重组蛋白
  • 货号：
    CSB-EP015250HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MX2重组蛋白
  • 货号：
    CSB-EP015250HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MX2重组蛋白
  • 货号：
    CSB-BP015250HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MX2重组蛋白
  • 货号：
    CSB-MP015250HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MX2
  • Uniprot No.：
  • 别名：
    Interferon induced GTP binding protein Mx2; Interferon regulated resistance GTP binding protein MXB; Interferon-induced GTP-binding protein Mx2; Interferon-regulated resistance GTP-binding protein MxB; MX 2; MX dynamin like GTPase 2; Mx2; MX2_HUMAN; MXB; Myxovirus (influenza virus) resistance 2; Myxovirus resistance 2; Myxovirus resistance protein 2; p78 related protein; p78-related protein; Second interferon induced protein p78
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-715
  • 氨基酸序列
    MSKAHKPWPY RRRSQFSSRK YLKKEMNSFQ QQPPPFGTVP PQMMFPPNWQ GAEKDAAFLA KDFNFLTLNN QPPPGNRSQP RAMGPENNLY SQYEQKVRPC IDLIDSLRAL GVEQDLALPA IAVIGDQSSG KSSVLEALSG VALPRGSGIV TRCPLVLKLK KQPCEAWAGR ISYRNTELEL QDPGQVEKEI HKAQNVMAGN GRGISHELIS LEITSPEVPD LTIIDLPGIT RVAVDNQPRD IGLQIKALIK KYIQRQQTIN LVVVPCNVDI ATTEALSMAH EVDPEGDRTI GILTKPDLMD RGTEKSVMNV VRNLTYPLKK GYMIVKCRGQ QEITNRLSLA EATKKEITFF QTHPYFRVLL EEGSATVPRL AERLTTELIM HIQKSLPLLE GQIRESHQKA TEELRRCGAD IPSQEADKMF FLIEKIKMFN QDIEKLVEGE EVVRENETRL YNKIREDFKN WVGILATNTQ KVKNIIHEEV EKYEKQYRGK ELLGFVNYKT FEIIVHQYIQ QLVEPALSML QKAMEIIQQA FINVAKKHFG EFFNLNQTVQ STIEDIKVKH TAKAENMIQL QFRMEQMVFC QDQIYSVVLK KVREEIFNPL GTPSQNMKLN SHFPSNESSV SSFTEIGIHL NAYFLETSKR LANQIPFIIQ YFMLRENGDS LQKAMMQILQ EKNRYSWLLQ EQSETATKRR ILKERIYRLT QARHALCQFS SKEIH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.
  • 基因功能参考文献：
    1. Study identifies MxB as a potent pan-herpesvirus restriction factor which blocks the uncoating of viral DNA from the incoming viral capsid. PMID: 29773792
    2. These data demonstrate that human MXB but not other human or murine MX proteins inhibit murine cytomegalovirus propagation. Evidently, the viral protein expression was delayed and the viral DNA amount in nucleus was diminished in MXB expressing cells indicating an obstruction of nuclear entry. PMID: 30032029
    3. Therefore, these results demonstrate the importance of MxB in alpha interferon-mediated inhibition of HIV-1 infection. PMID: 29925663
    4. The dynamin-like MxB GTPase serves as a broadly acting intracellular restriction factor that controls retrovirus as well as herpesvirus infections. PMID: 29950411
    5. MxB dimers form higher order oligomers that restrict retroviral replication by binding to the viral capsid. [review] PMID: 27492442
    6. These experiments suggested that MxB does not contribute to the HIV-1 restriction observed in IFN-alpha-treated human cells. PMID: 26719253
    7. Together, the data demonstrate that interferon-beta inhibits foamy virus early in infection and that MxB is not a restriction factor of foamy virus. PMID: 26609934
    8. We propose that lower-order oligomerization of MX2 is sufficient for the effective inhibition of human immunodeficiency virus type 1. PMID: 26446602
    9. Study analyzed the evolutionary history of MX2 at the inter- and intraspecific level and use this information to identify a haplotype that associates with natural resistance to HIV-1 infection in humans; the ancestral (G) allele of rs2074560 protects from HIV-1 infection with a recessive effect. PMID: 24930137
    10. The high prevalence of MxB-resistant mutations in the CypA-binding loop indicates the significant selective pressure of MxB on HIV-1 replication in vivo. PMID: 25571928
    11. MxB inhibits HIV-1 by interfering with minimally two steps of infection, nuclear entry and post-nuclear trafficking and/or integration, without destabilizing the inherent catalytic activity of viral preintegration complexes. PMID: 25348155
    12. HIV-seronegative women who use Depo-Provera have the highest levels of Mx2 expression, highlighting a possible mechanism for hormonal modulation of HIV resistance. PMID: 25562491
    13. The amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid has been characterized. PMID: 25363729
    14. MxB oligomerization is important for the ability of MxB to bind to the HIV-1 core proteins. PMID: 25568212
    15. A triple-arginine motif in the amino-terminal domain and oligomerization are required for HIV-1 inhibition by human MX2. PMID: 25673704
    16. structural analysis of assembly of human anti-HIV dynamin-like protein MxB/Mx2 PMID: 25446123
    17. MxB binding to the HIV-1 capsid. PMID: 25123063
    18. To identify protein domains of MX2 that specify HIV-1 inhibition. PMID: 24899177
    19. Through a combination of in vitro evolution and unbiased mutagenesis, s further map the determinants of sensitivity to Mx2 and reveal that multiple capsid (CA) surfaces define sensitivity to Mx2. PMID: 24760893
    20. Taken together, it is concluded that human MxB protein inhibits HIV-1 DNA integration by a CypA-dependent mechanism. PMID: 24055605
    21. MX2 is therefore a cell-autonomous, anti-HIV-1 resistance factor whose purposeful mobilization may represent a new therapeutic approach for the treatment of HIV/AIDS PMID: 24048477
    22. findings indicate that MX2 is an effector of the anti-HIV-1 activity of type-I IFN, and suggest that MX2 inhibits HIV-1 infection by inhibiting capsid-dependent nuclear import of subviral complexes PMID: 24121441
    23. The MX2 promoter is activated by Trichostatin A (TSA) treatment and by serum depletion according to promoter reporter assays in HEK 293 cells. PMID: 20494980
    24. the MX2 gene to be significantly less expressed in comparison with normal subjects in the white blood cells of narcoleptic patients PMID: 17702266
    25. The expression level of the MX2 gene tended to be downregulated in subjects carrying HLA-DQB1*0602, compared with that of the control subjects without this allele. PMID: 18517045

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Nucleus, nuclear pore complex. Note=Localization to nuclear pores requires GTP-binding.
  • 蛋白家族：
    TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family
  • 数据库链接：

    HGNC: 7533

    OMIM: 147890

    KEGG: hsa:4600

    STRING: 9606.ENSP00000333657

    UniGene: Hs.926