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  4. Recombinant Human Hypoxia-inducible lipid droplet-associated protein (HILPDA), partial

Recombinant Human Hypoxia-inducible lipid droplet-associated protein (HILPDA), partial

  • 中文名称：
    人HILPDA重组蛋白
  • 货号：
    CSB-YP896910HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HILPDA重组蛋白
  • 货号：
    CSB-EP896910HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HILPDA重组蛋白
  • 货号：
    CSB-EP896910HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HILPDA重组蛋白
  • 货号：
    CSB-BP896910HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HILPDA重组蛋白
  • 货号：
    CSB-MP896910HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HILPDA
  • Uniprot No.：
  • 别名：
    C7orf68; chromosome 7 open reading frame 68; HIG 2; HIG2; HIG2_HUMAN; HILPDA; hypoxia inducible gene 2; Hypoxia-inducible gene 2 protein; Hypoxia-inducible lipid droplet-associated protein; Hypoxia-inducible protein 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.
  • 基因功能参考文献：
    1. The expression of HIG2 was regulated by PVT1-miR-150 signaling, we transfected Hep G2 and BEL-7402 cell lines with PVT1 shRNA vectors or the combination of PVT1 shRNA vectors and miR-150 inhibitors. PMID: 30205391
    2. s conclude that HIG2 is overexpressed in GBM and upregulated by hypoxia. PMID: 27329597
    3. Study showed for the first time that HIG-2 and SOX11 mutually co-regulate each other, and that HIG-2 and SOX11 knock-down promote increased proliferation in a non-synergistic manner in primary mantle cell lymphoma cells. PMID: 26757780
    4. data uncover HILPDA as a novel PPAR target that raises hepatic triglyceride storage via regulation of triglyceride secretion. PMID: 24876382
    5. Data indicate that HIG2 (hypoxia-inducible gene 2) is a HIF-1alpha target in regulating cell survival during hypoxia. PMID: 23916472
    6. there was no significant relationship between HIG2 expression and age, clinical stage and histology in either cervical cancer or endometrial cancer. PMID: 21614900
    7. Data show that DBN1, SETMAR and HIG2 are direct transcriptional targets of the SOX11 protein. PMID: 21124928
    8. HIG2 was up-regulated by hypoxia and HIF inducers in all cell types and mouse organs investigated and abundantly expressed in renal clear-cell carcinomas PMID: 20624928
    9. may be used as a marker for early detection of ovarian clear cell adenocarcinoma PMID: 20134266

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  • 亚细胞定位：
    Lipid droplet. Secreted. Membrane; Single-pass membrane protein.
  • 组织特异性：
    Highly expressed in renal cell carcinoma cells but barely detectable in adjacent normal kidney tissue. Detected in some cervical and endometrial cancers. Expression also detected in fetal kidney with little or no expression observed in normal adult heart,
  • 数据库链接：

    HGNC: 28859

    OMIM: 617905

    KEGG: hsa:29923

    STRING: 9606.ENSP00000257696

    UniGene: Hs.706124