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  4. Recombinant Human Hsc70-interacting protein (ST13)

Recombinant Human Hsc70-interacting protein (ST13)

  • 中文名称：
    人ST13重组蛋白
  • 货号：
    CSB-YP022744HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ST13重组蛋白
  • 货号：
    CSB-EP022744HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ST13重组蛋白
  • 货号：
    CSB-EP022744HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ST13重组蛋白
  • 货号：
    CSB-BP022744HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ST13重组蛋白
  • 货号：
    CSB-MP022744HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ST13
  • Uniprot No.：
  • 别名：
    AAG 2; AAG2; Aging associated protein 2; F10A1_HUMAN; FAM10A1; FAM10A4; FLJ27260; Heat shock 70kD protein binding protein ; Hip; HOP; Hsc70 interacting protein; Hsc70-interacting protein; Hsp70 interacting protein; HSPABP 1; HSPABP; HSPABP1; MGC129952; OTTHUMP00000028873; P48; PRO0786; Progesterone receptor associated p48 protein; Progesterone receptor-associated p48 protein; Protein FAM10A1; Putative tumor suppressor ST13; Renal carcinoma antigen NY REN 33; Renal carcinoma antigen NY-REN-33; SNC 6; SNC6; ST 13; St13; Suppression of tumorigenicity 13 ; Suppression of tumorigenicity 13 (colon carcinoma); Suppression of tumorigenicity 13 protein; Suppression of tumorigenicity protein 13
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-369
  • 氨基酸序列
    MDPRKVNELR AFVKMCKQDP SVLHTEEMRF LREWVESMGG KVPPATQKAK SEENTKEEKP DSKKVEEDLK ADEPSSEESD LEIDKEGVIE PDTDAPQEMG DENAEITEEM MDQANDKKVA AIEALNDGEL QKAIDLFTDA IKLNPRLAIL YAKRASVFVK LQKPNAAIRD CDRAIEINPD SAQPYKWRGK AHRLLGHWEE AAHDLALACK LDYDEDASAM LKEVQPRAQK IAEHRRKYER KREEREIKER IERVKKAREE HERAQREEEA RRQSGAQYGS FPGGFPGGMP GNFPGGMPGM GGGMPGMAGM PGLNEILSDP EVLAAMQDPE VMVAFQDVAQ NPANMSKYQS NPKVMNLISK LSAKFGGQA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.
  • 基因功能参考文献：
    1. A novel susceptibility gene, ST13, coding for a cochaperone of the glucocorticoid receptor, is associated with exacerbations in asthmatic children and young adults despite their ICS use. PMID: 25616159
    2. St13 is a proliferation regulator that inhibits tumor growth in colorectal neoplasms and may affect cell migration. PMID: 23125081
    3. Akt phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase. PMID: 21767636
    4. A single amino acid substitution (L211S) resulted in a loss of Hip function. This mutation also appears to disrupt the interaction of Hip with Hsp70 in vitro PMID: 21240662
    5. Hip has been identified as a novel substrate of GRK5 in vitro and in cells, and phosphorylation of Hip by GRK5 plays a role in modulating CXCR4 internalization PMID: 21728385
    6. These results strongly indicate ST13 mediated by adenovirus triggers colorectal cell apoptosis via ASK1-JNK signaling cascade PMID: 20512919
    7. S-nitrosoglutathione corrects DeltaF508 CFTR trafficking by inhibiting Hop expression PMID: 20534503
    8. The expression levels of ST13 cannot serve as a biomarker for early stages of PD. PMID: 20193743
    9. Hip functions to promote the efficiency of glucocorticoid receptor maturation in cells PMID: 15071092
    10. The expression of ST13 decreases in colorectal cancer tissue compared with that in adjacent normal tissue. ST13 is mostly expressed in colorectal epithelia and adenocarcinoma cells. PMID: 15637739
    11. tetratricopeptide repeat domain is required for effects of CHIP on alpha-synuclein inclusion morphology, number of inclusions, and proteasomal degradation as well as the direct interaction of CHIP with Hsp70 implicates their cooperation in these processes PMID: 15845543
    12. The expression levels of the ST13 gene were significantly decreased in primary tumors compared with adjacent mucosa (P<0.05). PMID: 16358374
    13. results suggest that granzyme B-mediated loss of HIP expression occurs in vivo, and in a coordinate fashion with loss of BID, pro-caspase-8 and pro-caspase-3; data implicate the Hsp70 co-chaperone HIP in the proteolytic cascade of some apoptotic pathways PMID: 17013759
    14. analysis of similarity between the chloroplast translocon component, Tic40, and the human co-chaperone, Hsp70-interacting protein PMID: 17535810

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    FAM10 family
  • 数据库链接：

    HGNC: 11343

    OMIM: 606796

    KEGG: hsa:6767

    STRING: 9606.ENSP00000216218

    UniGene: Hs.712713