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  4. Recombinant Human Homeobox protein Hox-D3 (HOXD3)

Recombinant Human Homeobox protein Hox-D3 (HOXD3)

  • 中文名称：
    人HOXD3重组蛋白
  • 货号：
    CSB-YP010686HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HOXD3重组蛋白
  • 货号：
    CSB-EP010686HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HOXD3重组蛋白
  • 货号：
    CSB-EP010686HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HOXD3重组蛋白
  • 货号：
    CSB-BP010686HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HOXD3重组蛋白
  • 货号：
    CSB-MP010686HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HOXD3
  • Uniprot No.：
  • 别名：
    Homeo box D3 ; Homeobox D3; Homeobox protein Hox D3; Homeobox protein Hox-4A; Homeobox protein Hox-D3; Homeobox protein HoxD3; Homeodomain protein; HOX 1D; HOX 4; Hox 4.1; Hox 4A; HOX D3; Hox-4.1 mouse homolog of ; HOX1D; HOX4; Hox4.1; HOX4A; HOXD 3; HOXD3; HXD3_HUMAN; MGC10470
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-432
  • 氨基酸序列
    MLFEQGQQAL ELPECTMQKA AYYENPGLFG GYGYSKTTDT YGYSTPHQPY PPPAAASSLD TDYPGSACSI QSSAPLRAPA HKGAELNGSC MRPGTGNSQG GGGGSQPPGL NSEQQPPQPP PPPPTLPPSS PTNPGGGVPA KKPKGGPNAS SSSATISKQI FPWMKESRQN SKQKNSCATA GESCEDKSPP GPASKRVRTA YTSAQLVELE KEFHFNRYLC RPRRVEMANL LNLTERQIKI WFQNRRMKYK KDQKAKGILH SPASQSPERS PPLGGAAGHV AYSGQLPPVP GLAYDAPSPP AFAKSQPNMY GLAAYTAPLS SCLPQQKRYA APEFEPHPMA SNGGGFASAN LQGSPVYVGG NFVESMAPAS GPVFNLGHLS HPSSASVDYS CAAQIPGNHH HGPCDPHPTY TDLSAHHSSQ GRLPEAPKLT HL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. The findings indicate that miR-203a inhibits hepatocellular carcinoma cell invasion, metastasis, and angiogenesis by negatively targeting HOXD3 and suppressing cell signaling through the VEGFR pathway. PMID: 29402992
    2. EGR1 is a key player in the transcriptional control of miR-203a, and that miR-203a acts as an anti-oncogene to suppress HCC tumorigenesis by targeting HOXD3 through EGFR-related cell signaling pathways. PMID: 27244890
    3. the HOXD3 gene promotes colorectal cancer cell growth and plays a pivotal role in the development and survival of malignant human colorectal cancer cells. PMID: 27499213
    4. These results validate the association between promoter hypermethylation of ABHD9 and HOXD3 and prostate cancer recurrence PMID: 24718283
    5. HOXD3 promoter hypermethylation is correlated with clinicopathologic features in prostate cancer. This correlation is more common in older, higher risk patients. PMID: 24847526
    6. High expression of HOXD3 correlates with invasive breast cancer. PMID: 22935821
    7. quantitative increase in promoter methylation levels of HOXD3 is associated with prostate cancer progression PMID: 21207416
    8. HOXD3 methylation distinguishes low-grade prostate cancers from intermediate and high-grade ones. PMID: 20212450
    9. transduction of antisense DNA into human melanoma cells results in decreased invasive and motile activities PMID: 12405287
    10. Hox D3 coordinately regulates the expression of integrin alpha5beta1 and integrin alphavbeta3 during angiogenesis in vivo. PMID: 14610084
    11. HoxD3 may provide a means to directly improve collagen deposition, angiogenesis and closure in poorly healing diabetic wounds. PMID: 14633614
    12. HOXD3 may play an important role in regulating cerebral angiogenesis, and that gene transfer of HOXD3 may provide a novel and potent means to stimulate angiogenesis PMID: 15545924
    13. The karyotype of our patient suggests another possible locus of the Duane syndrome, and the mapped genes around the deleted region, 1q42.13-43, contain possible candidate genes such as a homeobox gene. PMID: 17126050
    14. Further validation of candidate genes on a separate cohort of low and high grade prostate cancers by quantitative MethyLight analysis has allowed us to confirm DNA hypermethylation of HOXD3 and BMP7... PMID: 19283074

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family
  • 数据库链接：

    HGNC: 5137

    OMIM: 142980

    KEGG: hsa:3232

    STRING: 9606.ENSP00000249440

    UniGene: Hs.93574