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  4. Recombinant Human Homeobox protein Hox-C9 (HOXC9)

Recombinant Human Homeobox protein Hox-C9 (HOXC9)

  • 中文名称：
    人HOXC9重组蛋白
  • 货号：
    CSB-YP010679HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HOXC9重组蛋白
  • 货号：
    CSB-EP010679HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HOXC9重组蛋白
  • 货号：
    CSB-EP010679HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HOXC9重组蛋白
  • 货号：
    CSB-BP010679HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HOXC9重组蛋白
  • 货号：
    CSB-MP010679HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HOXC9
  • Uniprot No.：
  • 别名：
    Homeo box C9; Homeobox C9; Homeobox protein Hox C9 ; Homeobox protein Hox-3B; Homeobox protein Hox-C9; Hox 3B; HOX3; HOX3B; Hoxc9; HXC9_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-260
  • 氨基酸序列
    MSATGPISNY YVDSLISHDN EDLLASRFPA TGAHPAAARP SGLVPDCSDF PSCSFAPKPA VFSTSWAPVP SQSSVVYHPY GPQPHLGADT RYMRTWLEPL SGAVSFPSFP AGGRHYALKP DAYPGRRADC GPGEGRSYPD YMYGSPGELR DRAPQTLPSP EADALAGSKH KEEKADLDPS NPVANWIHAR STRKKRCPYT KYQTLELEKE FLFNMYLTRD RRYEVARVLN LTERQVKIWF QNRRMKMKKM NKEKTDKEQS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. HOXC9 knockdown inhibited the metastasis and stem cell-like phenotype of GC cells without significant effects on cell proliferation as a direct target of miR-26a. PMID: 30205370
    2. downregulation of HOXC9 releases its transcriptional inhibition of DAPK1, resulting in the activation of the DAPK1-Beclin1 pathway, which induces autophagy in glioblastoma cells PMID: 26582930
    3. HOXC9 and HOXC10 may play an important role in the development of obesity, adverse fat distribution, and subsequent alterations in whole-body metabolism and adipose tissue function. PMID: 26647900
    4. Results provide a set of the essential genes in the miR-193a-3p/HOXC9/DNA damage response/oxidative stress pathway axis as the diagnostic targets for the guided anti-bladder cancer chemotherapy. PMID: 25444900
    5. HOXC9 coordinates diverse cellular processes associated with differentiation by directly activating and repressing the transcription of distinct sets of genes. PMID: 24274069
    6. HoxC9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma. PMID: 23579273
    7. We did not find any potential pathological mutations in the Hoxc9 gene among Chinese patients with congenital heart disease. PMID: 22106857
    8. The data identify HOXC9 as an endothelial cell active transcriptional repressor promoting the resting, antiangiogenic endothelial cell phenotype in an interleukin 8-dependent manner PMID: 21493894
    9. HOXC9 links cell-cycle exit and neuronal differentiation and is a prognostic marker in neuroblastoma. PMID: 21507931
    10. Up-regulation of HOXC9 was detected in a set of 54 astrocytomas of different grades and significantly associated with malignancy. PMID: 17588684
    11. Methylated state of this set of genes may be more specific to the late rather than the early stage of NSCLC. PMID: 19506903

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Abd-B homeobox family
  • 数据库链接：

    HGNC: 5130

    OMIM: 142971

    KEGG: hsa:3225

    STRING: 9606.ENSP00000302836

    UniGene: Hs.658823