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  4. Recombinant Human Homeobox protein Hox-A7 (HOXA7)

Recombinant Human Homeobox protein Hox-A7 (HOXA7)

  • 中文名称：
    人HOXA7重组蛋白
  • 货号：
    CSB-YP010657HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HOXA7重组蛋白
  • 货号：
    CSB-EP010657HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HOXA7重组蛋白
  • 货号：
    CSB-EP010657HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HOXA7重组蛋白
  • 货号：
    CSB-BP010657HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HOXA7重组蛋白
  • 货号：
    CSB-MP010657HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HOXA7
  • Uniprot No.：
  • 别名：
    ANTP; Antp, Drosophila, homolog of; Homeobox 1A; Homeobox A7; Homeobox protein Hox 1.1; Homeobox protein Hox A7; Homeobox protein Hox-1A; Homeobox protein Hox-A7; HOX1; HOX1.1; HOX1.1, mouse, homolog of; Hox1A; HOXA7; HXA7_HUMAN; OTTHUMP00000024835
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-230
  • 氨基酸序列
    MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST VPGLYNVNSP LYQSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA CDKTDEGALH GAAEANFRIY PWMRSSGPDR KRGRQTYTRY QTLELEKEFH FNRYLTRRRR IEIAHALCLT ERQIKIWFQN RRMKWKKEHK DEGPTAAAAP EGAVPSAAAT AAADKADEED DDEEEEDEEE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. Silencing of HOTAIR and HOXA7 could effectively inhibit tumor growth and increase chemosensitivity of ovarian tumors in nude mice. PMID: 29455183
    2. data suggest that HOXA7 could serve as a diagnostic marker for OSCC or a treatment target PMID: 28529281
    3. Results showed that HOXA7 was highly expressed in liver cancer cells which related with poorer prognosis. Its overexpression significantly promoted invasion and metastasis of liver cancer cells by activating Snail expression. PMID: 27600149
    4. The homeodomain and N- and C-termini are critical to transcriptional activation by Hoxa1 protein. The N-terminus also modulates interaction with Pbx1a protein during DNA-binding. PMID: 20336696
    5. HOXA7 might be a new gene candidate that influences the maturation of acute myeloid leukemia. PMID: 26828989
    6. HOXA7 promotes cell proliferation, and these changes were mediated by cyclin E1/CDK2 PMID: 25501982
    7. variants in the HOXA7 and HOXA9 genes are not common in Chinese women with Mullerian duct abnormalities PMID: 25246116
    8. This finding contributes to our understanding of the role HOXA7 plays in regulating the proliferation of ER-positive cancer cells. PMID: 24099775
    9. Hoxa7, Hoxa9 and Hox cofactor Meis1 were identified as AP-2alpha target genes, which are involved in myeloid leukemogenesis. PMID: 23660297
    10. Data show that up-regulation of the HOXA7, HOXA9, HOXA11, and PBX3 resulting from the down-regulation of miR-181 family members probably contribute to the poor prognosis of patients with nonfavorable cytogenetically abnormal AML (CA-AML). PMID: 22251480
    11. found evidence for association of bone geometry variation with an SNP in ENPP1, a gene in the mineralization pathway. The alteration of a binding site of the deregulator of extracellular matrix HOXA7 warrants further investigation PMID: 19888898
    12. Taken together, these results support the notion that down-regulation of PCGF2 is sufficient to induce granulocytic differentiation of HL-60 cells via de-repression of HOXA7 gene expression. PMID: 22085718
    13. Several targets of MLL fusions, MEIS1, HOXA7, HOXA9, and HOXA10 are functionally related and have been implicated in leukemias. Each of the four genes was knocked down separately in the precursor B-cell leukemic line RS4;11 expressing MLL-AF4. PMID: 21518888
    14. HOXA7, PIXT1 and PRRX1 homeobox genes have different patterns of expression in oral squamous cell carcinomas depending on its histological features. PMID: 21323949
    15. A novel mechanistic role for HOXA7 in modulating granulosa cell proliferation via upregulation of EGFR. PMID: 20540809
    16. B-lineage development can proceed in t(4;11) leukemic blasts in the absence of HOX-A gene expression. PMID: 14562113
    17. Hox A7-sustained expression disturbs the regulation of cell adhesive and migratory capacities on fibronectin during early differentiation. PMID: 14704364
    18. Study reveals the preferential expression of HOXA7 by germinal vesicle (GV) oocytes. PMID: 16597639
    19. HOXA7 staining of tumor cell nuclei is correlated significantly with improved disease-specific survival, which is suggestive of the biological and potentially clinical importance of subcellular HOXA7 localization. PMID: 17959889

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family
  • 数据库链接：

    HGNC: 5108

    OMIM: 142950

    KEGG: hsa:3204

    STRING: 9606.ENSP00000242159

    UniGene: Hs.610216