Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human Homeobox protein Hox-A13 (HOXA13)

Recombinant Human Homeobox protein Hox-A13 (HOXA13)

  • 中文名称：
    人HOXA13重组蛋白
  • 货号：
    CSB-YP010651HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HOXA13重组蛋白
  • 货号：
    CSB-EP010651HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HOXA13重组蛋白
  • 货号：
    CSB-EP010651HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HOXA13重组蛋白
  • 货号：
    CSB-BP010651HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HOXA13重组蛋白
  • 货号：
    CSB-MP010651HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HOXA13
  • Uniprot No.：
  • 别名：
    Homeo box 1J; Homeo box A13; Homeobox 1J; Homeobox A13; Homeobox protein Hox A13; Homeobox protein Hox-1J; Homeobox protein Hox-A13; Homeobox protein HOXA13; Homeobox1J; HomeoboxA13; HOX 1; HOX 1J; Hox 1J protein; HOX A13; HOX1; HOX1J; HOXA 13; HOXA13; HXA13_HUMAN; Transcription factor HOXA13
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-388
  • 氨基酸序列
    MTASVLLHPR WIEPTVMFLY DNGGGLVADE LNKNMEGAAA AAAAAAAAAA AGAGGGGFPH PAAAAAGGNF SVAAAAAAAA AAAANQCRNL MAHPAPLAPG AASAYSSAPG EAPPSAAAAA AAAAAAAAAA AAASSSGGPG PAGPAGAEAA KQCSPCSAAA QSSSGPAALP YGYFGSGYYP CARMGPHPNA IKSCAQPASA AAAAAFADKY MDTAGPAAEE FSSRAKEFAF YHQGYAAGPY HHHQPMPGYL DMPVVPGLGG PGESRHEPLG LPMESYQPWA LPNGWNGQMY CPKEQAQPPH LWKSTLPDVV SHPSDASSYR RGRKKRVPYT KVQLKELERE YATNKFITKD KRRRISATTN LSERQVTIWF QNRRVKEKKV INKLKTTS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. Data suggest that patients with HOXA13-positive hepatocellular carcinomas experience worse overall survival than those with HOXA13-negative HCC; HOXA13 and HOTTIP (know regulator of HOXA13 expression) are expressed in the same neoplastic hepatocyte populations. (HOTTIP = long noncoding RNA HOTTIP) PMID: 29035381
    2. prognostic value of HOXA13 in solid tumors PMID: 29678634
    3. HOXA13 is an unfavorable prognostic factor and a novel oncogene for prostate cancer. PMID: 28766961
    4. Our study indicated that alteration of EPHA7 promoter transactivation produced by missensemutations of HOXA13 provided a molecular basis for HFGS. PMID: 28947713
    5. Findings indicate that the recruitment of HOXA13-HOTTIP and HOXA13-HOTAIR to different sites in the BMP7 promoter is crucial for the oncogenic fate of human gastric cells. PMID: 28782268
    6. The results of our study show that high expression of HOXA13 is associated with the progression of bladder cancer and that HOXA13 might serve as a biomarker for prognosis of bladder cancer. PMID: 27830363
    7. Knockdown of HoxA13 caused the downregulation of long non-coding RNA HOTTIP and insulin growth factor-binding protein 3 (IGFBP-3) genes, indicating that both were targets of HoxA13. PMID: 27144338
    8. Findings indicated that HOTTIP modulated HOXA13 at both the transcriptional and posttranscriptional levels in ESCC cells. PMID: 28534516
    9. HoxA13 increases myometrial cell contractility by enhancing the secretion of IL-1beta, resulting in an up-regulation of CAP and other proinflammatory cytokine expression. PMID: 26982635
    10. HOXA13 is involved in HSAinduced EMT in HKC cells and upregulation of HOXA13 exerts a beneficial effect in EMT, which may be associated with the GR signaling pathway. PMID: 27176855
    11. expression levels of HOTTIP and HOXA13 were both higher in gastric cancer which was poorly differentiated, at advanced TNM stages and exhibited lymph node-metastasis. Spearman analyses indicated that HOTTIP and HOXA13 had a highly positive correlation both in non-tumor mucosae and cancer lesions. Collectively, these findings suggest that HOTTIP and HOXA13 play important roles in gastric cancer progression. PMID: 27108607
    12. Down-regulation of HOTTIP and HOXA13 was associated with cell growth and cell cycle, and exerts tumor-suppressive functions in the genesis and progression of prostate cancer, providing a potential attractive therapeutic approach for this malignancy. PMID: 27064878
    13. Atypical hand-foot-genital syndrome and developmental delay due to de novo mutations in HOXA13 and NRXN1 PMID: 26590955
    14. HOXA13 promotes glioma progression in part via Wnt- and TGF-beta-induced epithelial-mesenchymal transition PMID: 26356815
    15. This pregnancy-maintaining regionalization of myometrial function may be mediated by HoxA13 PMID: 26485220
    16. Transfection of HOXA13 in HKCs could inhibit the degree of EMT induced by albumin-overload, possibly by increasing BMP-7 expression. PMID: 26695677
    17. HOTTIP/HOXA13 axis is a potential therapeutic target and molecular biomarker for pancreatic ductal adenocarcinoma. PMID: 25889214
    18. study demonstrates that aberrant reduction of HOTTIP and HOXA13, which have a bidirectional regulatory loop, may play an important role in the pathogenesis of HSCR PMID: 26043692
    19. serum HOXA13 may serve as a biomarker for early hepatocellular carcinoma diagnosing and predicting outcome. PMID: 25341685
    20. the present study demonstrated that ANXA2 and SOD2 are potential target genes of HOXA13 and their coexpression predicts the poor prognosis of Esophageal squamous cell carcinoma patients. PMID: 24626613
    21. Our study highlights the key role of HOTTIP and HOXA13 in hepatocellular carcinoma development. PMID: 24114970
    22. two de novo cases of hand-foot-genital syndrome associated with polyalanine expansions in HOXA13 were identified. PMID: 23532960
    23. Validated HOXA13 as a novel prognostic marker in gastric cancer based on immunohistochemistry and statistical analysis. HOXA13 expression was significantly up-regulated in cancerous tissues compared with the corresponding non-cancerous mucosa. PMID: 23592225
    24. A total of 14 DNA sequence variations (10 novel and 4 known) within exonic and untranslated regions were detected in HOXA10 and HOXA13 among our cohorts of female genital malformations. PMID: 23376215
    25. Results provide an additional support to a hypothesis that HOXA13 might participate in the carcinogenesis of esophageal squamous cell carcinoma. PMID: 21893383
    26. conclude that the non-conserved residue, V373 is critical for structurally recognizing TAA in the major groove, and that HOXA13 dimerization is required to activate transcription of target genes PMID: 21829694
    27. Overexpression of HOXA13 mRNA is associated with hepatocellular carcinoma. PMID: 21626505
    28. A novel mutation of HOXA13 in a family with hand-foot-genital syndrome. PMID: 19591980
    29. The expression of HOXA13 can be detected in esophageal squamous cell carcinoma and is a negative independent predictor of disease-free survival. PMID: 19145497
    30. a NUP98 primer and a degenerate primer corresponding to the third helix of the NUP98 was fused in-frame to HOXA13 in the patient with MDS(myelodysplastic syndrome). PMID: 11830496
    31. A novel 2-bp deletion in the HOXA13 gene's highly conserved promoter region alters a key residue in the recognition helix of the homeodomain and is likely to perturb HOXA13's DNA-binding properties, resulting in both a loss and specific gain of function. PMID: 11968094
    32. A novel stable polyalanine [poly(A)] expansion in the HOXA13 gene associated with hand-foot-genital syndrome: proper function of poly(A)-harbouring transcription factors depends on a critical repeat length? PMID: 12073020
    33. The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with HOXA13. PMID: 12112533
    34. There seems to be no evidence that isolated hypospadias is commonly caused by mutations in HOXA13. PMID: 14675924
    35. analysis of HOXA13 polyalanine expansion proteins in hand-foot-genital syndrome PMID: 17935235
    36. Maintenance of appropriate HOX transcriptional program in adult fibroblasts may serve as a source of positional memory to differentially pattern the epithelia during homeostasis and regeneration. PMID: 18245445
    37. In the absence of HOXA13 function, placental endothelial cell morphology is altered, causing a loss in vessel wall integrity, edema of the embryonic blood vessels, and mid-gestational lethality. PMID: 18483557
    38. Vaginal HOXA13 (homeobox A13) expression is diminished in women with pelvic organ prolapse compared with women with normal support PMID: 19423998
    39. results showed that HOXA13 expression enhanced tumor growth in vitro and in vivo, and was a negative independent predictor of disease-free survival of patients with esophageal squamous cell carcinoma PMID: 19491265

    显示更多

    收起更多

  • 相关疾病：
    Hand-foot-genital syndrome (HFG); Guttmacher syndrome (GUTTS)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Abd-B homeobox family
  • 数据库链接：

    HGNC: 5102

    OMIM: 140000

    KEGG: hsa:3209

    STRING: 9606.ENSP00000222753

    UniGene: Hs.592172