Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human Histone-lysine N-methyltransferase SETDB2 (SETDB2)

Recombinant Human Histone-lysine N-methyltransferase SETDB2 (SETDB2)

  • 中文名称：
    人SETDB2重组蛋白
  • 货号：
    CSB-YP822307HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SETDB2重组蛋白
  • 货号：
    CSB-EP822307HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SETDB2重组蛋白
  • 货号：
    CSB-EP822307HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SETDB2重组蛋白
  • 货号：
    CSB-BP822307HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SETDB2重组蛋白
  • 货号：
    CSB-MP822307HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SETDB2
  • Uniprot No.：
  • 别名：
    C13orf4; Chromosome 13 open reading frame 4 ; Chronic lymphocytic leukemia deletion region 8; Chronic lymphocytic leukemia deletion region gene 8; Chronic lymphocytic leukemia deletion region gene 8 protein; Clld8; CLLL8; Gm293; H3-K9-HMTase; Histone H3-K9 methyltransferase; Histone-lysine N-methyltransferase SETDB2; KMT1F; Lysine N-methyltransferase 1F; Probable histone-lysine N-methyltransferase H3 lysine-9 specific; SEB2; SET domain bifurcated 2; SET domain protein; bifurcated; 2; SETB2_HUMAN; Setdb2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-719
  • 氨基酸序列
    MGEKNGDAKT FWMELEDDGK VDFIFEQVQN VLQSLKQKIK DGSATNKEYI QAMILVNEAT IINSSTSIKG ASQKEVNAQS SDPMPVTQKE QENKSNAFPS TSCENSFPED CTFLTTENKE ILSLEDKVVD FREKDSSSNL SYQSHDCSGA CLMKMPLNLK GENPLQLPIK CHFQRRHAKT NSHSSALHVS YKTPCGRSLR NVEEVFRYLL ETECNFLFTD NFSFNTYVQL ARNYPKQKEV VSDVDISNGV ESVPISFCNE IDSRKLPQFK YRKTVWPRAY NLTNFSSMFT DSCDCSEGCI DITKCACLQL TARNAKTSPL SSDKITTGYK YKRLQRQIPT GIYECSLLCK CNRQLCQNRV VQHGPQVRLQ VFKTEQKGWG VRCLDDIDRG TFVCIYSGRL LSRANTEKSY GIDENGRDEN TMKNIFSKKR KLEVACSDCE VEVLPLGLET HPRTAKTEKC PPKFSNNPKE LTVETKYDNI SRIQYHSVIR DPESKTAIFQ HNGKKMEFVS SESVTPEDND GFKPPREHLN SKTKGAQKDS SSNHVDEFED NLLIESDVID ITKYREETPP RSRCNQATTL DNQNIKKAIE VQIQKPQEGR STACQRQQVF CDEELLSETK NTSSDSLTKF NKGNVFLLDA TKEGNVGRFL NHSCCPNLLV QNVFVETHNR NFPLVAFFTN RYVKARTELT WDYGYEAGTV PEKEIFCQCG VNKCRKKIL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
  • 基因功能参考文献：
    1. SETDB2 transcripts were overexpressed in renal cell tumor subtypes and associated with prognosis. PMID: 29099276
    2. Findings implicate SET domain bifurcated 2 (SETDB2) locus in the longstanding links of handedness with asthma and other atopic diseases. PMID: 29234167
    3. our data indicated that SETDB2 is often over-expressed in gastric cancer tissues and cell lines and SETDB2 overexpression significantly accelerated cell proliferation, migration and invasion of gastric cancer cells PMID: 27572307
    4. the relation of genetic variation in SETDB2-and its paralogue SETDB1-with different handedness phenotypes in 950 healthy adult participants, was investigated. PMID: 26572639
    5. Results indicate that the IgE-associated AT/G polymorphism (rs386770867) regulates transcription of SETDB2. PMID: 26378653
    6. these findings identify Setdb2 as a novel regulator of the immune system in acute respiratory viral infection. PMID: 26709698
    7. Results provide evidence that CLLD8/KMT1F is recruited to heterochromatin regions and contributes in vivo to the deposition of trimethyl marks in concert with SUV39H1/KMT1A.SUV39H1/KMT1A. PMID: 20404330

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily
  • 组织特异性：
    Ubiquitous. Highest expression in heart, testis and ovary.
  • 数据库链接：

    HGNC: 20263

    OMIM: 607865

    KEGG: hsa:83852

    STRING: 9606.ENSP00000326477

    UniGene: Hs.631789