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  4. Recombinant Human Histatin-3 (HTN3)

Recombinant Human Histatin-3 (HTN3)

  • 中文名称：
    人HTN3重组蛋白
  • 货号：
    CSB-YP010879HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HTN3重组蛋白
  • 货号：
    CSB-EP010879HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HTN3重组蛋白
  • 货号：
    CSB-EP010879HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HTN3重组蛋白
  • 货号：
    CSB-BP010879HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HTN3重组蛋白
  • 货号：
    CSB-MP010879HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HTN3
  • Uniprot No.：
  • 别名：
    HTN3; HIS2; Histatin-3; Basic histidine-rich protein; Hst; Histidine-rich protein 3; PB) [Cleaved into: Histatin-3; His3-(20-44)-peptide; His3 20/44; His3-(1-25)-peptide; His3 1/25; Histatin-3 1/25; Histatin-6); His3-(20-43)-peptide; His3 20/43; His3-(1-24)-peptide; His3 1/24; Histatin-3 1/24; Histatin-5); His3-(20-32)-peptide; His3 20/32; His3-(1-13)-peptide; His3 1/13; Histatin-3 1/13); His3-(20-31)-peptide; His3 20/31; His3-(1-12)-peptide; His3 1/12; Histatin-3 1/12); His3-(20-30)-peptide; His3 20/30; His3-(1-11)-peptide; His3 1/11; Histatin-3 1/11); His3-(24-32)-peptide; His3 24/32; His3-(5-13)-peptide; His3 5/13; Histatin-3 5/13); His3-(24-31)-peptide; His3 24/31; His3-(5-12)-peptide; His3 5/12; Histatin-11; Histatin-3 5/12); His3-(24-30)-peptide; His3 24/30; His3-(5-11)-peptide; His3 5/11; Histatin-12; Histatin-3 5/11); His3-(25-32)-peptide; His3 25/32; His3-(6-13)-peptide; His3 6/13; Histatin-3 6/13); His3-(25-30)-peptide; His3 25/30; His3-(6-11)-peptide; His3 6/11; Histatin-3 6/11); His3-(26-32)-peptide; His3 26/32; His3-(7-13)-peptide; His3 7/13; Histatin-3 7/13); His3-(26-31)-peptide; His3 26/31; His3-(7-12)-peptide; His3 7/12; Histatin-3 7/12); His3-(26-30)-peptide; His3 26/30; His3-(7-11)-peptide; His3 7/11; Histatin-3 7/11); His3-(31-51)-peptide; His3 31/51; His3-(12-32)-peptide; His3 12/32; Histatin-3 12/32; Histatin-4); His3-(31-44)-peptide; His3 31/44; His3-(12-25)-peptide; His3 12/25; Histatin-3 12/25; Histatin-9); His3-(31-43)-peptide; His3 31/43; His3-(12-24)-peptide; His3 12/24; Histatin-3 12/24; Histatin-7); His3-(32-44)-peptide; His3 32/44; His3-(13-25)-peptide; His3 13/25; Histatin-10; Histatin-3 13/25); His3-(32-43)-peptide; His3 32-43; His3-(13-24)-peptide; His3 13/24; Histatin-3 13/24; Histatin-8); His3-(33-44)-peptide; His3 33/44; His3-(14-25)-peptide; His3 14/25; Histatin-3 14/25); His3-(33-43)-peptide; His3 33/43; His3-(14-24)-peptide; His3 14/24; Histatin-3 14/24); His3-(34-44)-peptide; His3 34/44; His3-(15-25)-peptide; His3 15/25; Histatin-3 15/25); His3-(34-43)-peptide; His3 34/43; His3-(15-24)-peptide; His3 15/24; Histatin-3 15/24); His3-(45-51)-peptide; His3 45/51; His3-(26-32)-peptide; His3 26/32; Histatin-3 26/32); His3-(47-51)-peptide; His3 47/51; His3-(28-32)-peptide; His3 28/32; Histatin-3 28/32); His3-(48-51)-peptide; His3 48/51; His3-(29-32)-peptide; His3 29/32; Histatin-3 29/32)]
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-51
  • 氨基酸序列
    D SHAKRHHGYK RKFHEKHHSH RGYRSNYLYD N
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.
  • 基因功能参考文献：
    1. This aim of this study was to identify novel biomarkers using comparative global proteome analysis to improve the risk assessment for recurrent coronary events. Beta -defensin-128 and histatin-3 may be potential biomarkers whch may be used to improve risk the stratification for recurrent coronary events. PMID: 28627688
    2. the availability of Cu during exposure of Candida albicans to histatin-5 (Hist-5) modulates its antifungal activity. PMID: 28763199
    3. The aim of this study was to achieve a molecular understanding and a physico-chemical insight of the obtained small angle X-ray scattering and to gain information of the conformational changes of Histatin 5 due to altering salt content, charge distribution, and net charge. PMID: 26914439
    4. Histatin 5 Salivary Complexes PMID: 26544073
    5. Hst 5 may affect mitochondrial functions and cause oxidative stress; however, the ultimate cause of cell death is by volume dysregulation and ion imbalance triggered by osmotic stress. [Review] PMID: 24951439
    6. High intensity of caries is associated with increased levels of some salivary components - sIgA, histatin-5 and lactoperoxidase. PMID: 24974109
    7. analysis of histatin 5 uptake by Candida albicans utilizes polyamine transporters Dur3 and Dur31 proteins PMID: 22033918
    8. Histatin-5 is a likely transport molecule for toxic Ni(II) in human saliva.Its binding constant to nickel is five time higher than that of albumin. PMID: 21741339
    9. Hst 5 binding to beta-glucans on the cell wall of C. albicans is salt-sensitive. Uptake of Hst 5 shows dose-dependent translocation and intracellular accumulation precede vacuole expansion and propidium iodide uptake. PMID: 20487276
    10. Killing of Candida albicans requires cellular uptake and energy metabolism (Histatin 5) PMID: 11816973
    11. caused a loss of cell viability concomitant with a decrease in cellular volume as determined both by a classical candidacidal assay with exogenous Hst 5 and by using a genetically engineered C. albicans strain expressing Hst 5 (salivary histatin 5) PMID: 12183519
    12. study provides evidence for a novel function for yeast Ssa1/2 heat-shock proteins as cell envelope binding receptors for histatin 5 that mediate fungicidal activity PMID: 12761219
    13. results suggest that the genesis of histatin 3-related peptides, being under the principal action of trypsin-like activities, is probably not a random process but rather follows a sequential fragmentation pathway; cleavage sites are identified PMID: 15272024
    14. A 20-residue-derived histatin 5 peptide preserves anticandidal activity, binds DNA, and has nuclease activity in the presence of copper and zinc ions. PMID: 17176059
    15. Two cationic lysine residues at positions 2 and 10 in the P-113 peptide of Histatin 5 are important for transport into the cytosol of Candida albicans and that binding and transport are independent functional events. PMID: 17999963
    16. key steps of its lethal mechanism against parasites PMID: 18230684
    17. Gene polymorphism at codon 23 of the histatin 3 gene was not associated with periodontitis in the Japanese population. Rather it appeared to be associated with resistance to periodontitis. PMID: 19753800

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  • 亚细胞定位：
    Secreted. Note=Secreted by serous acinar and demilune cells.
  • 蛋白家族：
    Histatin/statherin family
  • 数据库链接：

    HGNC: 5284

    OMIM: 142702

    KEGG: hsa:3347

    STRING: 9606.ENSP00000432561

    UniGene: Hs.654442