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  4. Recombinant Human High mobility group protein HMG-I/HMG-Y (HMGA1)

Recombinant Human High mobility group protein HMG-I/HMG-Y (HMGA1)

  • 中文名称：
    人HMGA1重组蛋白
  • 货号：
    CSB-YP010545HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HMGA1重组蛋白
  • 货号：
    CSB-EP010545HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HMGA1重组蛋白
  • 货号：
    CSB-EP010545HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HMGA1重组蛋白
  • 货号：
    CSB-BP010545HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HMGA1重组蛋白
  • 货号：
    CSB-MP010545HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HMGA1
  • Uniprot No.：
  • 别名：
    High mobility group (nonhistone chromosomal) protein isoforms I and Y; High mobility group AT hook 1; High mobility group AT-hook protein 1; High mobility group protein 1; High mobility group protein A1; High mobility group protein HMG-I/HMG-Y; High mobility group protein Ia; High mobility group protein R; HMG R; HMG-I(Y); HMGA1; HMGA1_HUMAN; HMGA1A; HMGIY; MGC12816; MGC4242; MGC4854; Nonhistone chromosomal high mobility group protein HMG I/HMG Y
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-107
  • 氨基酸序列
    SESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE VPTPKRPRGR PKGSKNKGAA KTRKTTTTPG RKPRGRPKKL EKEEEEGISQ ESSEEEQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
  • 基因功能参考文献：
    1. Study reveals HMGA1, a CK2 Substrate, as a drug-resistant target in non-small cell lung cancer (NSCLC). Results delineate the tyrosine kinase inhibitors (TKI) resistance-associated kinase-substrate network, suggesting a potential therapeutic strategy for overcoming TKI-induced resistance in NSCLC. PMID: 28290473
    2. HMGA1 overexpression increased FoxO1 mRNA and protein expression in vitro, in cultured HepG2 and HEK-293 cells by binding FoxO1 gene promoter, thereby activating FoxO1 gene transcription. PMID: 29052178
    3. High HMGA1 expression is associated with Esophageal Squamous Cell Carcinoma. PMID: 27882471
    4. The HMGA1 rs139876191 variant played a key role in a protective mechanism against proliferative diabetic retinopathy by downregulating the expression of vascular endothelial growth factor A (VEGFA), a major activator of neovascularization in diabetic retinopathy. PMID: 27991577
    5. results from Transwell and woundhealing experiments indicated that HMGA1 participates cell invasion and migration through the ILK/Akt/GSK3beta pathway PMID: 29152644
    6. Thrombocytosis was more prevalent in patients with inflammatory breast cancer (IBC)than in those with non-IBC and it was associated with poor prognosis. GRO and TGF-beta were associated with thrombocytosis in IBC. PMID: 28831670
    7. Findings demonstrate that proper subcellular localization of High-mobility group A1 (HMGA1) is important for its function in trophoblast cells, and suggest that aberrant cytoplasmic expression of HMGA1 contributes to the pathogenesis of preeclampsia through impairment of trophoblast migration. PMID: 28345487
    8. these results clearly indicate HMGA1 as a key regulator of the autophagic pathway in cancer cells. PMID: 28777374
    9. IGF2BP2 protein is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1. PMID: 28753127
    10. IL-24 inhibits AKT via regulating the HMGA1/miR-222 signaling node in human lung cancer cells and acts as an effective tumor suppressor. PMID: 27602961
    11. These data reveal an essential role for the molecular chaperone GRP78 in IGF-IR signaling and implicate the use of GRP78 inhibitors in blocking IGF-IR signaling in hepatoma cells. PMID: 28389416
    12. HMGA1 and MMP-11 may play a key role in the proliferation and progression of skin tumors in humans. PMID: 29374701
    13. HMGA1 overexpression in adherent A2780 cells increased cancer stem cell properties, including proliferation, spheroid-forming efficiency and the expression of stemness-related genes. In addition, HMGA1 regulated ABCG2 promoter activity through HMGA1-binding sites. PMID: 27561949
    14. Studies indicate that pseudogenes of the HMGA1 gene, that codes for the HMGA1a and HMGA1b proteins having a critical role in development and cancer progression. PMID: 26895108
    15. study revealed a subset of potential development-associated miRNAs and suggests a novel regulatory axis for myogenesis in which miR-195/497 promote myogenic differentiation by repressing the HMGA1-Id3 pathway. PMID: 28255268
    16. Findings demonstrate that a relationship exists between the HMGA1 rs146052672 variant and acute myocardial infarction, suggesting that defects at the HMGA1 locus may play a pathogenetic role. PMID: 27839822
    17. SNP rs5498 in ICAM-1 gene and IVS5-13insC variant in HMGA1 gene were not associated with the susceptibility of DR in the Chinese T2DM cohort. PMID: 26717491
    18. We show that the chromatin remodeling protein HMGA1 functions as a downstream effector of these biological responses to miR-296-5p and regulates Sox2 expression, a master driver of cell stemness, by modifying chromatin architecture at the Sox2 promoter PMID: 26898758
    19. tissue microarray revealed that HMGA1 was expressed in thyroid carcinoma more than that in normal thyroid tissues ; expression of HMGA1 and MMP-2 was identified to be positively correlated . The present study established the first link between HMGA1 and TGF-b1 in the regulation of thyroid cancer proliferation and invasion PMID: 28393241
    20. our research indicated an H19-miR138-HMGA1 pathway in regulating the migration and invasion of colon cancer, providing new insight for treatment of colon cancer. PMID: 28358427
    21. The results reported here indicate a critical role of HMGA1 in the development of glioblastoma multiforme; its suppression impairs proliferation and self-renewal of brain tumor stem cells PMID: 27486901
    22. miR-214 expression was poor while that of HMGA1 was high in cervical and colorectal cancer tissues. miR-214-re-expression or HMGA1 downregulation inhibited proliferation, migration and invasion of cancer cells while miR-214 inhibition had opposite effects. miR-214 was demonstrated to bind to the wild-type 3' untranslated region of HMGA1 but not with its mutant. PMID: 27537384
    23. HMGA1 is frequently expressed in cirrhotic tissues and HCCs and its expression is associated with high Edmondson grade and worse prognosis in HCC. PMID: 27855356
    24. Studies define a novel HMGA1-MMP-2 pathway involved in a subset of human carcinosarcomas and tumor progression in murine models. PMID: 27001612
    25. HMGA1 may function as an oncogene and modulate endometrial cancer cell migration and invasion by activating Wnt/beta-catenin pathway. PMID: 27470368
    26. Increased HMGA1 in pulmonary arterial endothelial cells resulting from dysfunctional BMPr2 signaling can transition endothelium to smooth muscle-like cells associated with pulmonary arterial hypertension. PMID: 27045138
    27. in splenic hemangioma with t(3;6)(q26;p21), the entire coding region of HMGA1 comes under the control of the TBL1XR1 promoter, bringing about dysregulation of HMGA1 PMID: 26708416
    28. This is the first report for the association between HMGA1 and S100A13 expression in the modulation of thyroid cancer growth and invasion. PMID: 27008379
    29. Data indicate that the high mobility group A1 (HMGA1) proteomic signature has prognostic value in breast cancer. PMID: 26527623
    30. In breast cancer patients, high levels of HMGA1 and CCNE2 expression are associated with the YAP/TAZ signature. PMID: 26265440
    31. HMGA1 is overexpressed in human breast carcinomas and its levels are associated with a particular endocrine status. PMID: 26251519
    32. Report epigenetic modification of miRNA targets HMGA transcripts on pituitary cells. PMID: 25557289
    33. Our data indicates that measuring urine high mobility group AT-hook 1 may serve as a useful diagnostic tool for serous epithelial ovarian cancer. PMID: 25586095
    34. The HMGA1 rs146052672 genotype variant had an overall statistically significant effect on increasing the risk of development of type 2 diabetes mellitus in Europeans. (Meta-analysis) PMID: 26296198
    35. Somatic mutation of mtDNA was associated with better prognosis of head and neck squamous cell carcinoma. PMID: 24976238
    36. Results show that HMGA1 binds CRMP1 promoter and regulates its expression in medulloblastoma cells. PMID: 26009886
    37. HMGA1 plays an important role on breast cancer aggressiveness and prognosis and may act as a promising target for prognostic prediction. PMID: 25772486
    38. CBX7/HMGA1b/NF-kappaB could take part in the same transcriptional mechanism that finally leads to the regulation of SPP1 gene expression in papillary thyroid carcinoma. PMID: 25595895
    39. The results of the present study indicate that miR-26a may be associated with human breast carcinogenesis, which inhibits tumor cell proliferation by targeting HMGA1. PMID: 25755724
    40. High expression of HMGA1 along with miR-26a downregulation indicated a worse prognosis for patients with urothelial bladder cancer. PMID: 25455159
    41. High HMGA1 expression is associated with colorectal cancer. PMID: 24696416
    42. Increased HMGA1 expression in human chondrocytes is associated with increased expression of IGFBP-3. PMID: 23036517
    43. HMGA1 plays an important role on NSCLC progression and prognosis and may act as a convictive biomarker for prognostic prediction PMID: 25344216
    44. results indicated that miR-142-3p may function as a tumor suppressor by targeting HMGA1 in osteosarcoma PMID: 24803022
    45. The prognostic significance of the HMGA-1 antigen was not confirmed in pituitary adenomas with residual tumor growth. PMID: 24452592
    46. our data indicate a critical role for HMGA1 in regulating both self-renewal and the symmetric/asymmetric division ratio in cancer stem cells PMID: 24833610
    47. HMGA1 is a key molecular switch required by cancer cells for tumor progression and a poorly differentiated, stem-like state. The HMGA1 gene and proteins are expressed at high levels in all aggressive tumors studied to date. Review. PMID: 24684280
    48. a differential control exerted by both Oct-1 and Oct-2 in the transcriptional regulation of the HMGA1 gene PMID: 24367622
    49. HMGA1 gene variant may have a role in type 2 diabetes, body mass index, and high-density lipoprotein cholesterol in a Hispanic-American population PMID: 24148075
    50. Results support a model in which the HMGA1/TAR interaction prevents the binding of transcription-activating cellular co-factors and Tat, subsequently leading to reduced HIV-1 transcription. PMID: 23392246

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  • 相关疾病：
    A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B.
  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    HMGA family
  • 数据库链接：

    HGNC: 5010

    OMIM: 600701

    KEGG: hsa:3159

    STRING: 9606.ENSP00000308227

    UniGene: Hs.518805