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  4. Recombinant Human Guanine nucleotide-binding protein G (I)/G (S)/G (T) subunit beta-3 (GNB3)

Recombinant Human Guanine nucleotide-binding protein G (I)/G (S)/G (T) subunit beta-3 (GNB3)

  • 中文名称：
    人GNB3重组蛋白
  • 货号：
    CSB-YP009606HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GNB3重组蛋白
  • 货号：
    CSB-EP009606HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GNB3重组蛋白
  • 货号：
    CSB-EP009606HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GNB3重组蛋白
  • 货号：
    CSB-BP009606HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GNB3重组蛋白
  • 货号：
    CSB-MP009606HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    G protein beta 3 subunit; GBB3_HUMAN; GNB3; GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3; GTP binding regulatory protein beta 3 chain; Guanine nucleotide binding protein (G protein) beta polypeptide 3; Guanine nucleotide binding protein G; Guanine nucleotide binding protein G(I)/G(S)/G(T) beta subunit 3; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Hypertension associated protein; IG; SG; Transducin beta chain 3; Tsubunit beta 3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-340
  • 氨基酸序列
    MGEMEQLRQE AEQLKKQIAD ARKACADVTL AELVSGLEVV GRVQMRTRRT LRGHLAKIYA MHWATDSKLL VSASQDGKLI VWDSYTTNKV HAIPLRSSWV MTCAYAPSGN FVACGGLDNM CSIYNLKSRE GNVKVSRELS AHTGYLSCCR FLDDNNIVTS SGDTTCALWD IETGQQKTVF VGHTGDCMSL AVSPDFNLFI SGACDASAKL WDVREGTCRQ TFTGHESDIN AICFFPNGEA ICTGSDDASC RLFDLRADQE LICFSHESII CGITSVAFSL SGRLLFAGYD DFNCNVWDSM KSERVGILSG HDNRVSCLGV TADGMAVATG SWDSFLKIWN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
  • 基因功能参考文献：
    1. Significant genetic differences of GNB3 rs5443 exist between Southeastern European Caucasians and other populations. Cluster headache pathophysiology and pharmacotherapy response may be affected by GNB3 polymorphisms. PMID: 29959630
    2. The polymorphism of FTO gene rs17817449 and GNB3 gene rs5443 (C825T) may be a genetic determinant of obesity in Saudi population whereas impact of MC4R Asn274Ser change could not be detected. PMID: 29937877
    3. the GNB3 C825T polymorphism may contribute to increased risk of cancer, especially of thyroid carcinoma (meta-analysis). PMID: 25536621
    4. Guanine nucleotide-binding protein (GNB3) C825T polymorphism is not associated with type 2 diabetes mellitus (T2DM). PMID: 28602143
    5. Meta-analysis: GNB3 C825T polymorphism is related to increased essential hypertension exclusively in Caucasians. PMID: 28540932
    6. Our study indicates that variations in OXTR and Gbeta3 genes are specifically associated with presence and severity of Separation Anxiety in childhood and adulthood, but not with depression or anxiety in general. PMID: 28499211
    7. Our results demonstrate the potential use of a GNB3-specific antisense morpholino, as a pharmacogenetic therapy for essential hypertension PMID: 27028457
    8. No relationship was found between the studied polymorphisms (14094 ACE gene, rs1800469 gene TGFbeta1, GNB3 gene rs5443, rs5186 AGTR1 gene) and the occurrence of primary vesicoureteral reflux. TT genotype polymorphism rs5443 of the GNB3 gene may be a protective factor for improved renal function in patients with primary vesicoureteral reflux. PMID: 27988909
    9. Interactions between GNB3, CREB1 and negative life events were revealed. Further evidence is provided about the role of the environment in genetic vulnerability to major depression. PMID: 28225778
    10. Bipolar patients with the TT genotype had a lower BMI, smaller waist circumference, and lower levels of lipids and leptin than those with the CT or CC genotypes undergoing the valproic acid treatment course. PMID: 26856249
    11. Expressed in cone photoreceptors and ON-bipolar cells, Gbeta3 is essential in phototransduction and ON-bipolar cell signaling. PMID: 27281386
    12. Mutational analysis of GNB3 in a cohort of 58 subjects with CSNB identified a sporadic case individual with a homozygous GNB3 mutation PMID: 27063057
    13. The GNB3 TT genotype is a risk factor for coronary artery disease independent of other established cardiovascular risk factors in Chinese hypertensive patients. PMID: 28067546
    14. The combined effects of ACE and GNB3 polymorphisms showed that no pulmonary hypertension patients with the ACE/GNB3 II/TT genotype exhibited clinical worsening. PMID: 26821322
    15. Although not statistically significant, women who carried the GNB3 T risk allele gained 6 pounds more than noncarriers, and mean 6-month postpartum BMI differed by 2.2 kg/m(2) between homozygous women PMID: 25510251
    16. TT genotype of GNbeta3 C825T is more common among patients with functional dyspepsia than among healthy controls. PMID: 26551933
    17. GNB3 C825T polymorphisms may be correlated with the efficacy of antidepressants in the treatment of MDD, especially among Asians patients. PMID: 25451402
    18. GNB3 TT genotype was associated with lower left ventricular ejection fraction at 6 and 12 months in women with peripartum cardiomyopathy. PMID: 26915373
    19. no significant difference in the distribution of genotypes between vasovagal syncope patients and control group PMID: 26925743
    20. The present review illustrates that the C825T polymorphism is associated with increased cardiovascular risk of death and disease in Caucasian patients, independently of other established cardiovascular risk factors. PMID: 25903425
    21. The T-allele of GNbeta3 C825Tcan increase susceptibility to depression. After stratification by ethnicity, the same association was found in the Asian subpopulation, but not the Caucasian subpopulation. PMID: 26147511
    22. our study showed association of C825T polymorphism of the GNB3 with obesity, but did not prove the association this with the degree of obesity i patients with AH. PMID: 26177133
    23. The GNB3 825T polymorphism is significantly associated with greater visceral fat and higher serum levels in Korean obese women. PMID: 25280441
    24. GNB3-C825T polymorphism is associated with risk of essential hypertension in the overall population, the Caucasians and the Chinese. PMID: 24346074
    25. Results show The GNB3 TT genotype was associated with greater therapeutic effect. PMID: 25306451
    26. TNF-alpha-308G/A and the GNB3 C825T polymorphisms are associated with obesity and Acute Myocardial infarction in the Taiwanese population. PMID: 22408428
    27. GNB3 825 TT genotype is a significant and independent risk factor for hard coronary events independent of other established cardiovascular risk factors at a population level in male PMID: 25463071
    28. No statistically significant differences in GNb3 allele frequencies were observed between oesophageal adenocarcinoma cases and controls PMID: 25659220
    29. this study does not show an association of GNB3 C825T polymorphism with IBS risk [meta-analysis] PMID: 24876757
    30. In elderly Chinese patients, the GNb3-C825T SNP is not associated with irritable bowel syndrome pathogenesis. PMID: 25037115
    31. mtDNA 5178A/C and 10398A/G, GNB3 C825T, and eNOS polymorphisms are useful as a genetic basis for longevity. PMID: 24376503
    32. a polymorphism in guanine nucleotide binding protein beta 3 (GNbeta3) was associated significantly with global sleep quality PMID: 24635757
    33. the cumulative evidence does not support the proposal that the haplotypes formed by common polymorphisms in the GNB3 might exert influence on representative cardiovascular factors/phenotypes. PMID: 24477587
    34. The results show that polymorphism in this gene does not predict long term prognosis in functional dyspepsia in Koreans PMID: 24827623
    35. This study failed to demonstrate a correlation between specific GNB3 SNPs, blood pressure and insulin resistance in hypertension, prehypertension and control groups. PMID: 24722130
    36. These results provide novel evidence suggesting genetic variation in the 5-prime region of GNB3 moderates depressive symptom trajectories among primary care attendees. PMID: 24882179
    37. The GNB3 C825T polymorphism influences the efficacy of sildenafil in patients with pulmonary hypertension. The time to clinical worsening was significantly longer in the TT genotype patients than in the CC/CT genotype patients. PMID: 24531084
    38. GNbeta3 variant C825T associates with functional dyspepsia under an additive model PMID: 24557575
    39. The presence of GNB3 825T-allele may impair athletic performance and may serve as a genetic marker of low capacity for athletic performance in male basketball players. PMID: 24901079
    40. C825T GNB3 gene polymorphism was found to be a significant risk factor for the incidence of cardiovascular disease independently of hypertension and other established CVD risk factors in a Japanese population. PMID: 23595158
    41. findings show C825T GNB3 polymorphism affects the duration and severity of postocclusive reactive hyperemia during the first and third trimesters of pregnancy PMID: 23667878
    42. Genetic association between the GNB3 C825T polymorphism and hypertension or stroke. [Meta-analysis] PMID: 23799054
    43. Interactions between genetic variants of FTO and GNB3 influence clinical parameters to augment hypertension PMID: 23691120
    44. Describe a recurrent copy number variation in a childhood obesity syndrome. This unbalanced chromosome translocation leads to duplication of over 100 genes on chromosome 12, including the obesity candidate gene G protein beta3 (GNB3). PMID: 23980137
    45. The gene polymorphisms GNB3 C825T might be a risk factor for POTS through the enhanced vagal withdrawal of the heart in children and adolescents. PMID: 22882749
    46. The GNB3 825T allele was associated with blunted lipolysis in obese females. PMID: 23061407
    47. The GNB3 polymorphism is an independent risk factor for vasculogenic erectile dysfunction in Iranian males. PMID: 22985949
    48. I/D polymorphism is a significant independent predictor for variability of plasma ACE activity but the ACE I/D and GNB3 C825T polymorphisms are not significant factors for HTA in the Tunisian population PMID: 23505911
    49. A splice variant of GTP-binding regulatory protein beta-3 is unstable, and unable to localize properly to the plasma membrane and to activate diverse Gbetagamma effectors including PLCbeta2/3, PI3Kgamma, ERKs and the Rho guanine exchange factor (RhoGEF) PLEKHG2. PMID: 22940628
    50. genetic variants of the ADD1 and GNB3 genes may have important roles in blood pressure response to the cold pressor test PMID: 22476228

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  • 相关疾病：
    Night blindness, congenital stationary, 1H (CSNB1H)
  • 蛋白家族：
    WD repeat G protein beta family
  • 数据库链接：

    HGNC: 4400

    OMIM: 139130

    KEGG: hsa:2784

    STRING: 9606.ENSP00000229264

    UniGene: Hs.631657