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  4. Recombinant Human Golgi resident protein GCP60 (ACBD3)

Recombinant Human Golgi resident protein GCP60 (ACBD3)

  • 中文名称：
    Recombinant Human Golgi resident protein GCP60(ACBD3),Yeast
  • 货号：
    CSB-YP863972HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Golgi resident protein GCP60(ACBD3),Yeast
  • 货号：
    CSB-EP863972HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Golgi resident protein GCP60(ACBD3),Yeast
  • 货号：
    CSB-EP863972HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Golgi resident protein GCP60(ACBD3),Yeast
  • 货号：
    CSB-BP863972HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Golgi resident protein GCP60(ACBD3),Yeast
  • 货号：
    CSB-MP863972HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ACBD3
  • Uniprot No.：
  • 别名：
    ACBD 3; ACBD3; Acyl CoA binding domain containing protein 3; Acyl Coenzyme A binding domain containing 3; Acyl-CoA-binding domain-containing protein 3; GCP 60; GCP60; GCP60_HUMAN; GOCAP 1; GOCAP1; Golgi complex associated protein 1 60kDa; Golgi complex associated protein 1; Golgi complex-associated protein 1; Golgi phosphoprotein 1; Golgi resident protein GCP60; GOLPH 1; GOLPH1; PAP 7; PAP7; PBR and PKA associated protein 7; PBR associated protein; PBR- and PKA-associated protein 7; Peripheral benzodiazepine receptor associated protein PAP7; Peripheral benzodiazepine receptor-associated protein PAP7; Peripherial benzodiazepine receptor associated protein; PKA (RIalpha) associated protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-528
  • 氨基酸序列
    AAVLNAERL EVSVDGLTLS PDPEERPGAE GAPLLPPPLP PPSPPGSGRG PGASGEQPEP GEAAAGGAAE EARRLEQRWG FGLEELYGLA LRFFKEKDGK AFHPTYEEKL KLVALHKQVL MGPYNPDTCP EVGFFDVLGN DRRREWAALG NMSKEDAMVE FVKLLNRCCH LFSTYVASHK IEKEEQEKKR KEEEERRRRE EEERERLQKE EEKRRREEEE RLRREEEERR RIEEERLRLE QQKQQIMAAL NSQTAVQFQQ YAAQQYPGNY EQQQILIRQL QEQHYQQYMQ QLYQVQLAQQ QAALQKQQEV VVAGSSLPTS SKVNATVPSN MMSVNGQAKT HTDSSEKELE PEAAEEALEN GPKESLPVIA APSMWTRPQI KDFKEKIQQD ADSVITVGRG EVVTVRVPTH EEGSYLFWEF ATDNYDIGFG VYFEWTDSPN TAVSVHVSES SDDDEEEEEN IGCEEKAKKN ANKPLLDEIV PVYRRDCHEE VYAGSHQYPG RGVYLLKFDN SYSLWRSKSV YYRVYYTR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells. Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase.; (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites.
  • 基因功能参考文献：
    1. These results reveal a mechanism of EV71 replication that involves host ACBD3 for viral replication. PMID: 28303920
    2. that ACBD3 may represent candidate therapeutic targets to enable the elimination of breast cancer stem cells PMID: 29307786
    3. ACBD3 was found as a gene expression variability marker in 8-cell human embryos. PMID: 26288249
    4. the component proteins of the machinery, OSBP, VAP, SAC1, and PITPNB, are all essential host factors for AiV replication. Importantly, the machinery is directly recruited to the RNA replication sites through previously unknown interactions of VAP/OSBP/SAC1 with the AiV proteins and with ACBD3. PMID: 29367253
    5. Results show that Aichi virus 3A protein activates the lipid kinase activity of PI4KIIIb,which activation is sensitized by the protein ACBD3. The interfaces between PI4KIIIbeta-ACBD3 and ACBD3-3A were mapped with hydrogen-deuterium exchange mass spectrometry. PMID: 27989622
    6. Kobuviral non-structural 3A proteins act as molecular harnesses to hijack the host ACBD3 protein. PMID: 28065508
    7. The s propose a model in which interaction between Salmonella enterica serovar Typhimurium SseF and SseG enables both proteins to bind ACBD3, thereby anchoring Salmonella-containing vacuoles at the Golgi network and facilitating bacterial replication. PMID: 27406559
    8. these findings suggest that ACBD3 has prominent impacts on cellular NAD(+) metabolism via regulating PARP1 activation-dependent auto-modification and thus cell metabolism and function. PMID: 25940138
    9. s found that NS5A and PI4KB competed for association of acyl-coenzyme A binding domain containing protein 3 (ACBD3), which inhibited hepatitis C virus replication. PMID: 24792752
    10. Host ACBD3, PI4KIIIBETA and Aichi virus proteins complexes enhances phosphatidylinositol 4-phosphate synthesis and is critical for viral replication. PMID: 24672044
    11. ACBD3 mediates mHtt cytotoxicity via a Rhes/mHtt/ACBD3 complex. PMID: 24012756
    12. s found that the Golgi protein acyl-coenzyme A binding domain-containing 3 (ACBD3), interacts with the 3A proteins of poliovaccine Sabintpe 2 and coxsackievirus A17 at viral RNA replication sites. PMID: 23926333
    13. ACBD3 plays an essential role in maintaining lipid homeostasis via regulating SREBP1's processing pathway and thus impacting cellular lipogenesis. PMID: 23166793
    14. identified ACBD3 as an interacting partner of PPM1L, and showed that this association, which recruits PPM1L to ER-Golgi membrane contact sites, is mediated by a GOLD (Golgi dynamics) domain in ACBD3 PMID: 22796112
    15. The data were consistent with PAP7 interacting with DMT1 and regulating DMT1 expression in K562 cells by modulating expression of DMT1 protein. PMID: 22383495
    16. The 3A protein of picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIbeta. PMID: 22258260
    17. results indicate that a viral protein/ACBD3/PI4KB complex is formed to synthesize PI4P at the AiV RNA replication sites and plays an essential role in viral RNA replication PMID: 22124328
    18. Molecular cloning, chromosomal localization and expression pattern of PAP7. PMID: 12692076
    19. GCP60 interacts preferentially with one of the golgin-160 caspase cleavage fragments (residues 140-311). This strong interaction prevented the golgin-160 fragment from accumulating in the nucleus when this fragment and GCP60 were overexpressed. PMID: 16870622
    20. nuclear translocation of golgin-160-(140-311) is a highly coordinated event regulated not only by cleavage of the golgin-160 head but also by the oxidation state of GCP60 PMID: 17711851

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  • 亚细胞定位：
    Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion.
  • 组织特异性：
    Ubiquitous, with highest expression in testis and ovary.
  • 数据库链接：

    HGNC: 15453

    OMIM: 606809

    KEGG: hsa:64746

    STRING: 9606.ENSP00000355777

    UniGene: Hs.520207