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  4. Recombinant Human Glutathione S-transferase theta-1 (GSTT1)

Recombinant Human Glutathione S-transferase theta-1 (GSTT1)

  • 中文名称：
    人GSTT1重组蛋白
  • 货号：
    CSB-YP009991HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GSTT1重组蛋白
  • 货号：
    CSB-EP009991HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GSTT1重组蛋白
  • 货号：
    CSB-EP009991HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GSTT1重组蛋白
  • 货号：
    CSB-BP009991HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GSTT1重组蛋白
  • 货号：
    CSB-MP009991HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GSTT1
  • Uniprot No.：
  • 别名：
    EC 2.5.1.18; Glutathione S transferase 5; Glutathione S transferase theta 1; Glutathione S-transferase theta-1; Glutathione transferase T1 1; Glutathione transferase T1-1; GST 5 5; GST CL1; GST class theta 1 ; GST class-theta-1; GSTT1; GSTT1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-240
  • 氨基酸序列
    GLELYLDLL SQPCRAVYIF AKKNDIPFEL RIVDLIKGQH LSDAFAQVNP LKKVPALKDG DFTLTESVAI LLYLTRKYKV PDYWYPQDLQ ARARVDEYLA WQHTTLRRSC LRALWHKVMF PVFLGEPVSP QTLAATLAEL DVTLQLLEDK FLQNKAFLTG PHISLADLVA ITELMHPVGA GCQVFEGRPK LATWRQRVEA AVGEDLFQEA HEVILKAKDF PPADPTIKQK LMPWVLAMIR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.
  • 基因功能参考文献：
    1. Tthis study suggests that GSTM1 active and GSTT1 null genotype combination might be a risk factor in developing mitochondrial disease. PMID: 29235020
    2. individuals who have GSTT1 null variant are at higher risk for developing seizure than those of GSTT1 wild genotype. PMID: 30179425
    3. The interaction of the MTHFR, GSTT1 and hypertension may constitute a predictive model of risk for early onset ischemic heart disease in the population of Yucatan, Mexico PMID: 29395491
    4. GSTT1 gene polymorphism is associated with liver diseases. PMID: 29582627
    5. Indel variants of GSTT1 were typed in breast cancer patients and normal controls. No significant association was found. PMID: 29267651
    6. Homozygous deletion of GSTT1 is associated with slower HIV disease progression. PMID: 29795558
    7. The null genotype of GSTT1 is a strong predisposing factor for psoriasis in North India. PMID: 29067933
    8. The patients homozygous for the GSTT1 null alleles showed a 1.5-fold increased risk of Alzheimer's disease. PMID: 29072550
    9. Results related to GSTT (-) allele and elevation in aspartate aminotransferase (AST) levels should be considered with caution as AST may be elevated in other pathophysiological conditions PMID: 29523098
    10. MnSODVal allele is a risk factor for systemic lupus erythematosus (SLE), as well as for SLE with neurologic manifestations, while homozygous GSTT1 genotype is a risk factor for SLE with musculoskeletal manifestations. PMID: 28711952
    11. Higher NO2 exposure was associated with lower forced vital capacity for carriers of the GSTT1 null genotype. Traffic-related air pollution exposures were associated with increased risk of asthma, wheeze and lower lung function in middle-aged adults. The interaction with the GSTT1 genotype suggests that deficient antioxidant mechanisms may play a role in these adverse health effects. PMID: 29074540
    12. Overall, GSTT1 null genotype was associated with an increased esophageal cancer risk when all studies in Chinese populations pooled into this meta-analysis. In stratified studies with geographical location, significantly increased risk was found in North China (OR = 1.45, 95%CI: 1.11-1.91) and in studies with population-based control (OR = 1.29, 95%CI: 1.07-1.55). PMID: 28980936
    13. Analyses of the GSTT1 polymorphisms indicated a positive correlation between the GSTT1 null genotype and the Esophageal Carcinom risk (OR = 1.233, 95% CI = 1.044-1.455, p for heterogeneity <0.001). In the GSTM1-GSTT1 interaction analysis, we discovered remarkably enhanced EC risk for patients with the GSTM1 and GSTT1 dual null genotypes (OR = 1.962, 95% CI = 1.178-3.268, p for heterogeneity <0.001) PMID: 29215312
    14. GSTT1 gene deletion has a strong effect on urinary1- and 2-(N-acetyl-L-cysteine-S-yl)-1-hydroxybut-3-ene levels, and therefore 1,3-butadiene carcinogen metabolism, in smokers. PMID: 28292921
    15. The young patients Tick-borne Encephalitis level by routine cytogenetics abnormal cells was significantly higher in carriers of inactive forms of gene GSTT1 than containing active homozygous variants of these genes. PMID: 28556645
    16. GSTT1 polymorphism is not associated with the higher risk of cardiovascular diseases, but affects lipid profile PMID: 28365671
    17. polymorphisms of the GSTM1 del and GSTT1 del genes were analysed by multiplex PCR PMID: 28770368
    18. Frequency of GSTT1 gene polymorphism is higher in patients with atherosclerosis then in control group. PMID: 28692121
    19. These fi ndings suggest that carriers of null genotypes for GSTT1 might be at increased genotoxic alkyl- ating effect after exposure to pesticides. PMID: 25427726
    20. GSTT1 genetic polymorphisms are not associated with the development of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. PMID: 26103006
    21. Carriers of the GSTT1 null genotype had an increased risk of asthma and allergic outcomes if exposed to traffic-related air pollution PMID: 27372567
    22. The GSTT1 null genotype is significantly associated with an increased susceptibility to inflammatory bowel disease and is a risk factor for both ulcerative colitis and Crohn's disease. PMID: 28472806
    23. Identify as a candidate gene associated with Hailey-Hailey disease. PMID: 27523793
    24. It was observed that the variant genotypes of GSTM1, GSTT1, GSTP1 and CYP1A1 did not significantly increase the risk of cervical cancer (CC), however, statistically significant increased risk was observed for women who used wood for cooking and had GSTM1 (null) genotype. PMID: 28361858
    25. we conclude that the GSTT1 null polymorphism is not associated with the risk of developing renal cancer, since it has limited role PMID: 26154646
    26. first meta-analysis to prove a positive effect of the interaction between GSTT1 null genotype and smoking status on the risk of Coronary Heart Disease. PMID: 27686690
    27. Study provided evidence on the role of the deletion polymorphisms in the 22q11.23 region during the onset of allergic rhinitis (AR) and suggested that GSTT1 gene could be potential AR-speci fi c locus. PMID: 24902621
    28. GSTT1 null genotype is significantly associated with increased risk of SCD among the population of northwestern region of Saudi Arabia. In addition, it may be one of the important factors responsible for hematological manifestations of SCD. PMID: 27885941
    29. Glutathione S-transferase T1 null genotypes are associated with increased susceptibility to coronary artery disease in Indian populations PMID: 27920455
    30. GSTT1 null genotype showed protection against coronary artery disease in a North Indian Punjabi population. PMID: 27215231
    31. Association of GSTT1 polymorphisms with bipolar disorder risk among a Tunisian population PMID: 28043918
    32. Genetically induced absence of the GSTT1 enzyme is an independent and powerful predictor of premature vascular morbidity and death in individuals with T2DM. PMID: 27173202
    33. polymorphism might enhance bladder cancer risk [meta-analysis] PMID: 27631264
    34. Genetic Polymorphism of GSTT1 is associated with Prostatic Carcinoma. PMID: 27268642
    35. GSTT1 genetic polymorphism is not associated with ovarian cancer. PMID: 25124586
    36. data support the involvement of glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1) in uterine leiomyoma liability, and especially its role as a genetic factor in the occurrence of this disease PMID: 26785830
    37. Glutathione S-transferase T1 Null Genotype is associated with Risk of Gastric Cancer. PMID: 27039739
    38. The impact of GSTM1/GSTT1 polymorphism for the risk of oral cancer. PMID: 25595865
    39. There was no interaction between glutathione S-transferase theta 1 polymorphism and traffic-related air pollution exposure during the first year of life for current hay fever. PMID: 27043549
    40. No statistically significant association was found between GSTM1 or GSTT1 null genotypes and varicocele in the overall data analysis. (Meta-analysis) PMID: 26782535
    41. null genotype associated with female infertility, though not significantly PMID: 25010410
    42. There were significantly higher levels of the GSTT1 null and the ACE II genotypes in ankylosing spondylitis patients compared to those in healthy controls PMID: 26186891
    43. results show that GSTT1 null and MDR1 polymorphisms could play a role in susceptibility to inflammatory bowel disease PMID: 26604430
    44. The GSTT1 null genotype was associated with significantly increased requirement of blood transfusion PMID: 25880856
    45. GSTT1 null genotype is a risk factor for patients with more primitive urologic malignancies. PMID: 26158735
    46. GSTT1-null genotype might be associated with the increased risk and enhanced susceptibility to oxidative stress in progressive myoclonus epilepsy patients PMID: 26552558
    47. polymorphisms modified bromo-trihalomethane exposure relation to semen quality PMID: 26970898
    48. The GSTT1 null genotype was more frequent in Brazilian women without endometriosis. PMID: 26350109
    49. GSTT1 gene polymorphisms are not associated with susceptibility of developing diabetic neuropathy in T2DM patients. PMID: 26435566
    50. In the present study, no risk of cervical cancer was observed in GSTT1 homozygous null genotype, except in smokers who showed a significant increased risk compared to nonsmokers. PMID: 26434855

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    GST superfamily, Theta family
  • 组织特异性：
    Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles.
  • 数据库链接：

    HGNC: 4641

    OMIM: 600436

    KEGG: hsa:2952

    STRING: 9606.ENSP00000248935

    UniGene: Hs.268573