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  4. Recombinant Human Glioma pathogenesis-related protein 1 (GLIPR), partial

Recombinant Human Glioma pathogenesis-related protein 1 (GLIPR), partial

  • 货号：
    CSB-EP009503HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    GLIPR1
  • Uniprot No.：
  • 别名：
    CRISP 7; CRISP7; GLI pathogenesis related 1; GLI pathogenesis-related 1 (glioma); Glioma pathogenesis related protein 1; Glioma pathogenesis-related protein 1; GLIP1_HUMAN; GliPR 1; GLIPR; GLIPR1; Protein RTVP-1; RELATED TO TESTIS SPECIFIC; VESPID; AND PATHOGENESIS PROTEINS 1; RTVP 1; RTVP1; Testes specific vespid and pathogenesis protein 1; testes-specific vespid and pathogenesis protein 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 来源：
    E.coli
  • 分子量：
    28.1kDa
  • 表达区域：
    22-232aa
  • 氨基酸序列
    ANILPDIENEDFIKDCVRIHNKFRSEVKPTASDMLYMTWDPALAQIAKAWASNCQFSHNTRLKPPHKLHPNFTSLGENIWTGSVPIFSVSSAITNWYDEIQDYDFKTRICKKVCGHYTQVVWADSYKVGCAVQFCPKVSGFDALSNGAHFICNYGPGGNYPTWPYKRGATCSACPNNDKCLDNLCVNRQRDQVKRYYSVVYPGWPIYPRNR
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Data found that GLIPR1 expression level was low in human bladder cancer tissues. Also, GLIPR1 was shown to inhibit the expression of TPX2. PMID: 28799673
    2. High GLIPR1 expression is associated with cisplatin resistance in lung cancer. PMID: 28771580
    3. The present study identified GLIPR1 and miR-16 as key components for regulating the proliferation, migration, invasion and cancer-initiating cells in osteosarcoma PMID: 27460987
    4. This study reveals a novel pathway that PRMT5/WDR77 regulates GLIPR1 expression to control lung cancer cell growth. PMID: 26988096
    5. Overexpression of RTVP-1 in human neural stem cells induced mesenchymal differentiation, whereas silencing of RTVP-1 in glioma stem cells (GSCs) decreased the mesenchymal transformation and stemness of these cells. PMID: 26267319
    6. RTVP-1 regulates glioma cell spreading, migration and invasion and that these effects are mediated via interaction with N-WASP and by interfering with the inhibitory effect of hnRNPK on the function of this protein. PMID: 26305187
    7. Data indicate that combining adenoviral vector-mediated GLIPR1 gene therap (AdGLIPR1) with radiotherapy may achieve additive or synergistic tumor control in selected prostate and bladder tumors. PMID: 23433894
    8. Based on the observed overexpression in AML samples, GliPR1 should be further explored as a potential target for AML PMID: 24008279
    9. miR-137 inhibits Glioblastom stem cell self-renewal and promotes their differentiation by targeting RTVP-1 which down-regulates CXCR4. PMID: 23714687
    10. GLIPR1 interacts with Hsc70, and GLIPR1 overexpression or Hsc70 knockdown leads to transcriptional suppression of AURKA and TPX2. PMID: 23333597
    11. GLIPR1 core structure has a conserved central cavity via which CAP proteins are likely to bind to shared ligands. PMID: 21931216
    12. Data show that the expression of GLIPR1 and c-Myc were inversely correlated in prostate cancer. PMID: 22025562
    13. RTVP-1 plays a role in the effect of serum response factor on glioma cell migration PMID: 21777672
    14. demonstrate that GLIPR1 is a methylation-silenced gene in the acute myeloid leukemia patients PMID: 21922325
    15. GLIPR1 expression is downregulated or even lost by promoter methylation in acute myeloid leukemia. PMID: 19483285
    16. X-ray data have been collected to beyond 1.9 A resolution from a crystal of GLIPR1 that belonged to the orthorhombic space group P2(1)2(1)2 with average unit-cell parameters a = 85.1, b = 79.5, c = 38.9 A and either a monomer or dimer PMID: 21045302
    17. Induction of GliPR expression by HIV-1 was confirmed in P4-CCR5 cells. PMID: 20356381
    18. Expression of the human RTVP-1 gene is down-regulated in human prostate cancer specimens compared with normal human prostate tissue at the mRNA and protein levels. PMID: 14871827
    19. In this study we report the identification and characterization of a novel p53 target gene cluster that includes human RTVP1 (hRTVP-1) together with two GLIPR1L genes (GLIPR1L1 and GLIPR1L2) on human chromosome 12q21 and mouse Rtvp1 PMID: 16714093
    20. RTVP-1b is a novel splice variant of human RTVP-1, which was isolated from the U87 glioma cell line PMID: 17825796
    21. a role for GLIPR1/RTVP-1 deregulation early in Wilms tumorigenesis. PMID: 18030365
    22. GLIPR1 is a proapoptotic tumor suppressor acting through the ROS-JNK pathway. PMID: 18199537

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  • 亚细胞定位：
    Membrane; Single-pass membrane protein.
  • 蛋白家族：
    CRISP family
  • 组织特异性：
    According to PubMed:8973356, it is ubiquitously expressed with high levels in lung and kidney and low levels in heart and liver. Highly expressed in cell lines derived from nervous system tumors arising from glia, low or absent in non-glial-derived nervou
  • 数据库链接：

    HGNC: 17001

    OMIM: 602692

    KEGG: hsa:11010

    STRING: 9606.ENSP00000266659

    UniGene: Hs.205558