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  4. Recombinant Human Germinal center B-cell-expressed transcript 2 protein (GCET2)

Recombinant Human Germinal center B-cell-expressed transcript 2 protein (GCET2)

  • 中文名称：
    人GCSAM重组蛋白
  • 货号：
    CSB-YP854052HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GCSAM重组蛋白
  • 货号：
    CSB-EP854052HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GCSAM重组蛋白
  • 货号：
    CSB-EP854052HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GCSAM重组蛋白
  • 货号：
    CSB-BP854052HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GCSAM重组蛋白
  • 货号：
    CSB-MP854052HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GCSAM
  • Uniprot No.：
  • 别名：
    GCAT2; Gcet; GCET2 germinal center expressed transcript 2; GCET2 germinal centre expressed transcript 2; Gcsam; GCSAM_HUMAN; Germinal center associated lymphoma ; Germinal center associated lymphoma protein; Germinal center B cell associated protein 2; Germinal center B-cell-expressed transcript 2 protein; Germinal center expressed transcript 2; Germinal center-associated lymphoma protein; Germinal center-associated signaling and motility protein; Germinal centre associated lymphoma ; Germinal centre associated lymphoma protein; Germinal centre B cell associated protein 2; Germinal centre expressed transcript 2; hGAL; M17; M17 L
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-178
  • 氨基酸序列
    MGNSLLRENR RQQNTQEMPW NVRMQSPKQR TSRCWDHHIA EGCFCLPWKK ILIFEKRQDS QNENERMSST PIQDNVDQTY SEELCYTLIN HRVLCTRPSG NSAEEYYENV PCKAERPRES LGGTETEYSL LHMPSTDPRH ARSPEDEYEL LMPHRISSHF LQQPRPLMAP SETQFSHL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
  • 基因功能参考文献：
    1. Diagnostic Utility of the Germinal Center-associated Markers GCET1, HGAL, and LMO2 in Hematolymphoid Neoplasms. PMID: 25203428
    2. These findings further elucidate the growing and complex role of HGAL in B-cell biology and suggest that membrane-bound and cytoplasmic HGAL protein differently regulates distinct biological processes. PMID: 25381061
    3. HGAL and LMO2 may be useful adjuncts in the identification of follicular lymphoma of the nongastric gastrointestinal tract. PMID: 22914613
    4. the germinal centre protein human germinal centre-associated lymphoma regulates B-cell receptor signalling in B-lymphocytes which, without appropriate control, may lead to B-cell lymphoproliferation. PMID: 23299888
    5. HGAL/GCET2 protein expression may function as a marker for germinal center B-cell type diffuse large B-cell lymphoma. PMID: 22743653
    6. Immunostaining for HGAL was more frequently positive than that for BCL6 and CD10 in follicular lymphomas PMID: 21988858
    7. Data suggest that both HGAL and LMO2 are directly regulated by the transcription repressor PRDM1--overexpression of PRDM1 down-regulates HGAL and LMO2; PRDM1 directly binds to promoters of both HGAL and LMO2 and represses genetic transcription. PMID: 21722313
    8. necessary for germinal center maintenance and confining B-cells to the germinal center microenvironment PMID: 21475040
    9. show that HGAL increases the binding of myosin to F-actin and inhibits the ability of myosin to translocate actin by reducing the maximal velocity of myosin head/actin movement PMID: 21447067
    10. HGAL is sensitive and specific marker for detecting follicular lymphoma in nodal and extranodal sites PMID: 21502424
    11. molecular mechanism underlying the inhibitory effects of germinal center-specific HGAL protein on the motility of GC-derived lymphoma cells PMID: 20844236
    12. Our results show that HGAL and LMO2 are sensitive markers for follicular lymphoma diagnosis. PMID: 20697248
    13. Study confirms and validates findings of a correlation between HGAL expression and outcome in classical HL. PMID: 19883310
    14. gene is induced by IL4 and expression strongly predicts survival in diffuse large B-cell lymphoma PMID: 12509382
    15. Results report the cloning of germinal center B-cell expressed transcripts 1 and 2 (GCET1 and 2), and show that both are expressed in follicular lymphoma and diffuse large B-cell lymphoma with germinal center B-cell differentiation PMID: 12819018
    16. The restricted expression and germinal center specificity of HGAL protein suggest that it may have an important role in the diagnosis of specific lymphomas PMID: 15677569
    17. HGAL is involved in negative regulation of lymphocyte migration, thus constraining lymphocytes to the germinal center PMID: 17823310
    18. The correlation of HGAL expression with the germinal center B-cell phenotype demonstrates the role of this marker in the classification of cutaneous large B-cell lymphomas PMID: 18264083
    19. results report the cloning of HGAL, a germinal center its expression pattern in normal tissues and hematologic malignancies, its induction by IL4, and the prognostic significance of its expression in predicting survival in diffuse large B-cell lymphoma PMID: 12509382

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  • 亚细胞定位：
    Cytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.
  • 组织特异性：
    Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen.
  • 数据库链接：

    HGNC: 20253

    OMIM: 607792

    KEGG: hsa:257144

    STRING: 9606.ENSP00000419485

    UniGene: Hs.49614